A porcine circovirus-2 mutant isolated in Brazil contains low-frequency substitutions in regions of immunoprotective epitopes in the capsid protein

Salgado, Rafael Locatelli; Vidigal, Pedro Marcus Pereira; Gonzaga, Natália Fialho; Souza, Luiz F. L. de; Polêto, Marcelo Depólo; Onofre, Thiago Souza; Eller, Monique Renon; Pereira, Carlos Eduardo; Fietto, Juliana Lopes Rangel; Bressan, Gustavo Costa; Guedes, Roberto Maurício Carvalho; Almeida, Márcia R.; Júnior, Abelardo Silva

doi:10.1007/s00705-015-2567-z

Cited by 5 publications

(7 citation statements)

References 46 publications

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“…Com o seu uso, houve redução significativa da prevalência da circovirose no Brasil (Guedes, 2012). Atualmente, há relatos de casos esporádicos da doença, mesmo em rebanhos vacinados (Salgado et al, 2015). Entre os fatores que parecem predispor a essas falhas vacinais estão: erros na conservação e/ou na aplicação ou na dosagem da vacina, que, também, podem incluir a não aplicação; interferência de outras doenças em curso na fase da vacinação; uso de vacinas fora da idade ideal, principalmente em leitões muito jovens; e possível insuficiência da imunidade vacinal na proteção contra variantes virais, como a PCV2b (Segalés, 2015).…”

Section: Doenças Respiratóriasunclassified

“…A boa situação sanitária da suinocultura brasileira é evidenciada pelos índices produtivos alcançados por seus rebanhos tecnificados, que são semelhantes aos de outros países, onde a atividade também é desenvolvida (Galloway et al, 2007;Salgado et al, 2015). Entre as ações de defesa sanitária animal no Brasil, estão a criação de Granjas de Reprodutores Suídeos Certificadas (GRSC) (Borges et al, 2011;Oliveira et al, 2014b;Brasil, 2016), bem como a concentração de esforços na vigilância, na profilaxia, no controle e na erradicação das doenças listadas pela Organização Mundial de Saúde Animal (OIE) (Ben Jebara et al, 2012;World Organisation for Animal Health, 2016).…”

Section: Introductionunclassified

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Principais ameaças sanitárias endêmicas da cadeia produtiva de suínos no Brasil

Zanella

Morés

Barcellos

2016

Pesq. agropec. bras.

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Resumo -O Brasil se destaca por ser o quarto maior produtor e exportador de carne suína. A ocorrência de determinadas doenças na produção animal é um dos fatores mais importantes para a suinocultura. Os patógenos de suínos podem ser divididos em três grupos: agentes de doenças transmitidas por alimentos de origem animal; agentes de doenças de importância estratégica para o sistema de defesa sanitária; e agentes de doenças responsáveis por prejuízos na produção animal. Algumas enfermidades, como a peste suína clássica e a febre aftosa, impactam duramente o mercado exportador; doenças endêmicas ou enzoóticas deterioram os índices produtivos e aumentam o custo de produção, com perda da competitividade; e doenças transmitidas por alimentos, embora não afetem os índices produtivos, podem causar danos à saúde humana e prejudicar as relações comerciais. O Brasil, por ser um expoente na produção e na exportação de suínos e derivados, deve estar atento a alguns aspectos relacionados à infraestrutura laboratorial, às medidas de biossegurança e aos cuidados necessários para impedir que determinadas doenças, ainda exóticas, infectem o rebanho brasileiro. Este artigo de revisão aborda as principais doenças endêmicas ou enzoóticas que causam prejuízo à produção de carne suína no Brasil.Termos para indexação: defesa sanitária animal, doenças enzoóticas, sanidade animal, suinocultura, zoonose. Main endemic health threats in the swine production chain in BrazilAbstract -Brazil stands out as the fourth largest producer and exporter of pork. The occurrence of certain diseases in animal production is one of the most important factors for swine production. Swine pathogens can be divided into three groups: agents of foodborne illnesses of animal origin; agents of strategically important diseases for the health protection system; and agents of diseases responsible for losses in animal production. Some diseases, such as classical swine fever and foot-and-mouth disease, impact heavily the export market; endemic or enzootic diseases deteriorate production rates and increase production costs, reducing competitiveness; and foodborne illnesses, despite not affecting production indexes, can cause damages to human health and harm commercial relations. Brazil, being an exponent in the production and export of pork and derivatives, must be aware of some aspects related to laboratory infrastructure, biosecurity measures, and care necessary to prevent certain, still exotic, diseases from infecting the Brazilian herd. This review addresses the main endemic or enzootic diseases that cause losses in pork production in Brazil.

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Section: Doenças Respiratóriasunclassified

Section: Introductionunclassified

Principais ameaças sanitárias endêmicas da cadeia produtiva de suínos no Brasil

Zanella

Morés

Barcellos

2016

Pesq. agropec. bras.

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“…The capsid protein of PCV2 was expressed in E. coli and used as an antigen as described by Salgado et al (2015). Ninety-six well microplates (Nunc Immuno™ MicroWell™ 96 Plates MaxiSorp™ Sigma-Aldrich, USA) were used and were coated with 5µg/well of antigen diluted in carbonate buffer (0.05M, pH 9.6) for twelve hours.…”

Section: Methodsmentioning

confidence: 99%

“…The interaction between PCV2 and natural hosts (wild and domestic pigs) is a complex process that begins with viral adhesion and entry into the cell (Nauwynck et al, 2012). This interaction results in the development of an adaptive immune response which tends to end the acute infection, although some animals may develop the persistent infection (Segalés et al, 2012). This persistent infection is expected in animals that will develop subclinical disease but not in animals that will develop the systemic infection (Segalés et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antibody response between pigs of Piau and a commercial breed naturally infected with Porcine circovirus 2

Bulos

Gonzaga

Souza

et al. 2016

Arq. Bras. Med. Vet. Zootec.

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“…The main threats to the guarantee of access to the international market are the sanitary issues of production, which is why the production chain of swine farming has been guided by its actions to comply with the standards established by the World Organization for Animal Health (OIE). One of the main goals of this sector is the establishment and maintenance of the status of free zone of Classical Swine Fever (CSF), according to the sanitary code of the terrestrial animals, followed by the National Suidae Health Program (Programa Nacional de Sanidade Suídea -PNSS) (Salgado et al 2015, Zanella et al 2016. The PNSS provides biosecurity norms and control of some endemic diseases for Certified Suidae Breeder Farms (Granjas de Reprodutores de Suídeos Certificados -GRSC), while in other types of farms only some diseases listed by the OIE are predicted to control.…”

Section: Introductionmentioning

confidence: 99%

Risk of exposure of farms and subsistence nurseries to contact with wild boar in southern Mato Grosso do Sul

et al. 2019

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With the advancement of wild boar distribution in the rural environment, its impacts are not limited to health in the pig sector, but the requirements for monitoring and control of the species are requirements laid down by the OIE for the recognition of classical swine fever free zone status. The construction of ecological models of favorability or suitability for the occurrence of pest species are necessary tools for the decision making on priority areas of management aiming at risk management. This work aims to map the level of suitability for the occurrence of wild boar in the southern state of Mato Grosso do Sul, as well as to identify the main risk variables for contact with the wild boar and evaluate the biosecurity measures adopted by commercial farms integrated in the south of the State of Mato Grosso do Sul. To evaluate the risk potential of wild boar for commercial and subsistence swine farming in southern Mato Grosso do Sul, a model of environmental suitability was constructed for this species in the swine producing region. This model considered different environmental strata, being the selection of the layers considered the physiological and behavioral characteristics of the species. In parallel, interviews were carried out in a sample of commercial farms integrating the region to survey the perception of the presence of the invasive species and the biosafety measures adopted. The results of this work indicate that the risk of contact among wild boars and animals reared in closed production systems may be high in the study area and only establishment of appropriate biosecurity measures that consider the characteristics and habits of the boar may prevent the intrusion of this species and contact with domestic swine. The built model can be considered of high reliability and it is recommended to apply it to other areas of the state, being a useful tool for the productive sector, environmental agencies and decision makers.

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A porcine circovirus-2 mutant isolated in Brazil contains low-frequency substitutions in regions of immunoprotective epitopes in the capsid protein

Cited by 5 publications

References 46 publications

Principais ameaças sanitárias endêmicas da cadeia produtiva de suínos no Brasil

Principais ameaças sanitárias endêmicas da cadeia produtiva de suínos no Brasil

Antibody response between pigs of Piau and a commercial breed naturally infected with Porcine circovirus 2

Risk of exposure of farms and subsistence nurseries to contact with wild boar in southern Mato Grosso do Sul

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