A population K-PD model analysis of long-term testosterone inhibition in prostate cancer patients undergoing intermittent androgen deprivation therapy

DeJongh, Joost; Ahsman, Maurice J.; Snelder, Nelleke

doi:10.1007/s10928-020-09736-7

Cited by 1 publication

(1 citation statement)

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“…The role of androgens in prostate cancer pathogenesis is still unclear. Testosterone-suppressive treatment can improve survival rates in patients with castration-resistant prostate cancer [49]. On the other hand, there are investigations demonstrating that low levels of testosterone are associated with more aggressive prostate cancer [50,51].…”

Section: Alterations To Sex Hormone Levelsmentioning

confidence: 99%

Effects of Obesity and Calorie Restriction on Cancer Development

Sergeeva

Рукша

Fefelova

2023

IJMS

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The risk of malignant tumor development is increasing in the world. Obesity is an established risk factor for various malignancies. There are many metabolic alterations associated with obesity which promote cancerogenesis. Excessive body weight leads to increased levels of estrogens, chronic inflammation and hypoxia, which can play an important role in the development of malignancies. It is proved that calorie restriction can improve the state of patients with various diseases. Decreased calorie uptake influences lipid, carbohydrate and protein metabolism, hormone levels and cell processes. Many investigations have been devoted to the effects of calorie restriction on cancer development in vitro and in vivo. It was revealed that fasting can regulate the activity of the signal cascades including AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), p53, mTOR, insulin/ insulin-like growth factor 1 (IGF1) and JAK-STAT. Up- or down-regulation of the pathways results in the decrease of cancer cell proliferation, migration and survival and the increase of apoptosis and effects of chemotherapy. The aim of this review is to discuss the connection between obesity and cancer development and the mechanisms of calorie restriction influence on cancerogenesis that stress the importance of further research of calorie restriction effects for the inclusion of this approach in clinical practice.

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Section: Alterations To Sex Hormone Levelsmentioning

confidence: 99%