A population-based study on the associations between chronic periodontitis and the risk of cancer

Chung, Shiu-Dong; Tsai, Ming Chieh; Huang, Chung Chien; Chen, Chao Hung

doi:10.1007/s10147-015-0884-6

Cited by 51 publications

(90 citation statements)

References 18 publications

(23 reference statements)

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“…() and Chung et al. () observed a higher risk of breast cancer among study participants who self‐reported having periodontal disease. Therefore, a meta‐analysis on this topic is of necessity.…”

Section: Discussionmentioning

confidence: 94%

“…Assessment methods for periodontal disease in previous large epidemiological studies were heterogeneous, most studies utilized self‐reported data by the patients or administrative data for the diagnosis of periodontal disease. Among the eight studies we included, six did not give clear diagnostic criteria (Arora, Weuve, Fall, Pedersen, & Mucci, ; Chung, Tsai, Huang, Kao, & Chen, ; Dizdar et al., ; Hujoel, Drangsholt, Spiekerman, & Weiss, ; Nwizu et al., ; Söder et al., ), and two studies give two and four diagnostic criteria, respectively (Michaud et al., ; Sfreddo et al., ). Michaud et al.…”

Section: Methodsmentioning

confidence: 99%

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Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Shi

Min

Sun

et al. 2018

J Clinic Periodontology

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Objective While some individual studies have suggested an association between periodontal disease and breast cancer, there has not been a formal meta‐analysis that collates the existing evidence supporting the hypothesis that periodontal disease leads to a higher risk of developing breast cancer. Accordingly, this meta‐analysis was conducted. Methods Relevant studies published until April 2018 were retrieved and were screened according to established inclusion criteria. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated to assess the association between periodontal disease and the risk of breast cancer and fixed effect models were used according to the results of the heterogeneity test. Results Eight studies, involving 168,111 individuals, were identified as having explored the association between periodontal disease and breast cancer. Summary estimates in view of adjusted data showed that periodontal disease did increase susceptibility to breast cancer (RR = 1.18, 95%CI: 1.11–1.26, I2 = 17.6%), with robust results confirmed by sensitivity analysis. Conclusion Our results provided evidence of a modest positive association between periodontal disease and breast cancer. Implementation of practical measures to prevent and treat periodontal disease is of great public health significance. Moreover, additional studies are recommended to explore this topic in more detail.

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Section: Discussionmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Shi

Min

Sun

et al. 2018

J Clinic Periodontology

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“…Table provides detailed information regarding the nine studies included in this meta‐analysis. Of the 10 studies, eight were prospective cohort studies (Ahn et al, ; Arora et al, ; Heikkilä et al, ; Hujoel et al, ; Michaud et al, , ; Momen‐Heravi et al, ; Nwizu et al, ), and two were retrospective cohort studies (Chou et al, ; Chung et al, ). The outcome was cancer incidence in seven studies (Arora et al, ; Chou et al, ; Chung et al, ; Michaud et al, , ; Momen‐Heravi et al, ; Nwizu et al, ) and cancer mortality in three studies (Ahn et al, ; Heikkilä et al, ; Hujoel et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…The self‐reporting of periodontal disease status could have introduced measurement error, which would most likely have been non‐differential and result in attenuation towards the null of any underlying association; consequently, the actual associations might in fact be stronger than those noted. However, misclassification is unlikely to be substantial given that most self‐reported questions about periodontal disease have good positive and negative predictive values, and these self‐reported measures were reasonably validated against objective measures (Arora et al, ; Michaud et al, ; Momen‐Heravi et al, ; Nwizu et al, ) or received a positive diagnosis based on their symptoms, medical history and the results of at least one diagnostic test (Chung et al, ). Second, different ethnicity and gender groups are studied, which can provide a further source of heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Is periodontitis a risk indicator for gastrointestinal cancers? A meta‐analysis of cohort studies

Zhang

Sun

Song

et al. 2019

J Clinic Periodontology

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Objective To evaluate the association between periodontitis and the incidence and mortality of gastrointestinal cancer. Method A comprehensive literature search was conducted to identify all relevant studies published prior to April 2019 according to the established inclusion criteria. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with a random‐effects model. Results We identified 10 studies with 26 estimates of the relationship between periodontitis and gastrointestinal cancer. The HR for the incidence of gastrointestinal cancer in periodontitis was 1.23 (95% CI: 1.10–1.37). Subgroup analyses showed that periodontitis was associated with an increased risk of gastrointestinal cancers in prospective cohort studies and high–quality studies, North American individuals, and individuals 18 years or older, as well as when the dental status was self‐reported and when the study was adjusted for smoking. A meta‐analysis of nine reports demonstrated that periodontitis was associated with increased mortality from gastrointestinal cancer (HR = 1.59, 95% CI: 1.16–2.16). Additionally, periodontitis was associated with mortality from pancreatic cancer (HR = 2.20, 95% CI: 1.44–3.37); thus, periodontitis may be a risk factor for pancreatic cancer. Conclusion Our meta‐analysis demonstrated that periodontitis may be a risk factor for gastrointestinal cancers. Additional prospective cohort studies are warranted to confirm these findings.

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“…[13,14] Of paramount importance in this context are the findings from epidemiologic studies, which suggested an association between periodontitis and/or tooth loss and the risk of cancers including lung cancer, esophagus cancer, gastric cancer, colorectal cancer and pancreatic cancer. [3,[15][16][17][18][19][20][21] The mechanism behind the claim connecting periodontitis and distant cancers might be related to the persistent periodontal infection, and the resultant inflammation that induce a state of systemic chronic inflammation, and eventually cancer. Surprisingly, periodontal pathogens, especially porphyromonas gingivalis and fusobacterium nucleatum have been isolated from some orodigestive cancer tissues, a matter that indicates potential roles for these pathogens in carcinogenesis and tumor proliferation at distant sites.…”

Section: Introductionmentioning

confidence: 99%

Periodontal disease, tooth loss, and the risk of liver cancer: A systematic review

Al‐Maweri¹,

Ibraheem²,

Al-Akhali³

et al. 2019

Preprint

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Background A number of epidemiological studies have suggested a positive association between periodontal diseases and oro-digestive cancers, including liver cancer. The present systematic review aimed to assess the potential association between periodontitis and/or tooth loss and the risk of liver cancer.Methods A comprehensive search of PubMed, Scopus and Web of Science databases was conducted in August 2019. The inclusion criteria comprised all observational studies that assessed the relationship between periodontitis or tooth loss and liver cancer. Case reports, animal studies, experimental studies, and reviews were excluded. Due to great heterogeneity among the included studies, no meta-analysis was conducted.Results Seven studies (five prospective cohorts, one cross-sectional, and one case-control) comprising 620,169 subjects (including 994 liver cancer cases) were included. The studies were conducted in the United States, Europe, and Asia. Four studies reported a positive association between periodontitis or tooth loss and the risk of liver cancer. One case-control study found some association between liver cancer and loss of 12-23 teeth, but such association was not replicated in patients with greater number of tooth loss. Contrarily, two studies failed to report any association between periodontitis and/or tooth loss and the risk of liver cancer.Conclusion The available evidence suggests a possible link between tooth loss/periodontitis and the risk of liver cancer. However, the evidence is not conclusive enough, a fact that drives to conduct more, well-designed, prospective cohort studies to further explore the potential association between periodontitis and the risk of liver cancer.

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A population-based study on the associations between chronic periodontitis and the risk of cancer

Abstract: We observed an increased risk for the subsequent development of a number of cancers among subjects with CP.

Cited by 51 publications

References 18 publications

Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Periodontal disease and susceptibility to breast cancer: A meta‐analysis of observational studies

Is periodontitis a risk indicator for gastrointestinal cancers? A meta‐analysis of cohort studies

Periodontal disease, tooth loss, and the risk of liver cancer: A systematic review

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