A population-based study of the epidemiology of hepatitis C in a North American population

Uhanova, Julia; Tate, Robert B.; Tataryn, Douglas J.; Minuk, Gerald Y.

doi:10.1016/j.jhep.2012.05.018

Cited by 21 publications

(17 citation statements)

References 16 publications

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“…This is in agreement with previous studies carried out in Libya, which showed a peak in the prevalence of HCV among those 46-55 years old [13]. Other studies, particularly from North America, also showed the highest prevalence in the 30-49 year age group in all racial groups [43,44]. …”

Section: Discussionsupporting

confidence: 92%

Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey

Daw

El-Bouzedi

2014

BMC Infect Dis

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BackgroundLibya is one of the largest countries in Africa and has the longest coast in the Mediterranean basin facing southern Europe. High rates of prevalence of viral hepatitis have been observed in various regions in Africa, but the prevalence in Libya is not well documented. We report on a large-scale nationwide study that evaluated the epidemiology of hepatitis B and hepatitis C in Libya and assessed the risk factors involved.MethodsA cross-sectional study was carried out in 2008 on 65,761 individuals all over Libya. The country was divided into 12 regions according to the population density and sampling within each region was carried out under the supervision of the National Centre for Prevention of Infectious Diseases. Serum samples were collected from both males and females of all ages in both urban and rural areas and tested for HBsAg for hepatitis B and anti-HCV antibody for hepatitis C. Prevalence rates were determined in regions and in different groups and correlated with different demographic and risk factors involved in the spread of these viruses.ResultsThe prevalence of hepatitis B and hepatitis C viruses varied regionally across the country. The overall prevalence of hepatitis B was 2.2% (95% CI 2.1%-2.3%) and was higher among males than females (1.4:1.0). Hepatitis C virus (HCV) prevalence was 1.2% (95% CI 1.1-1.3) and it increased gradually after the age of 30 years (0.7-0.9% for < 30 years; 3.6% for ≥ 60 years). Prevalence of HBsAg was 0.8-0.9% below the age of 10 years, and higher but similar in older age groups (2.3-2.7%). There was an association between literacy and prevalence of hepatitis, particularly for HCV. Hospital admission, surgical operation, blood transfusion, and intravenous drug use were the main risk factors, and they were associated independently with a higher prevalence rate of viral hepatitis.ConclusionsLibya may be considered an area of low-intermediate endemicity for hepatitis B virus infection, with lower rates in young age groups, and an area of low endemicity for hepatitis C. The prevalence of hepatitis B and C across Libya is not homogeneous, with indications of the effect of the higher rates in some neighbouring countries. Libya should adopt full coverage national plans and guidelines to face the future consequences of viral hepatitis, particularly hepatitis C virus.

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Section: Discussionsupporting

confidence: 92%

Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey

Daw

El-Bouzedi

2014

BMC Infect Dis

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“…The anti-HCV positive rate differed significantly between age groups, with a higher rate in those aged 40–59 years compared with those aged <40 years. The increase in anti-HCV positive rate with age was consistent with previous studies [10,11]. Young people have fewer opportunities to be infected with HCV.…”

Section: Discussionsupporting

confidence: 91%

Epidemiology of Hepatitis C Virus Infection and Risk Factor Analysis in the Hebei Province, China

Zhao

Shen

et al. 2013

PLoS ONE

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BackgroundIn 1985, a hepatitis C virus (HCV) outbreak caused by plasmapheresis donation was reported in the Hebei Province, China. However, studies assessing the epidemic features and risk factors of HCV in the general population of Hebei have been limited until now.MethodsThe multicenter cluster sampling method was used to collect samples. The participants were interviewed. Relevant information was obtained from the general population using a standardized questionnaire, and association and logistic regression analyses were conducted. Serum samples were taken to test anti-HCV by enzyme immunoassays.ResultsA total of 4562 participants from 11 cities of the Hebei Province were enrolled. The average anti-HCV positive rate was 0.62% (29/4562), which was 1.07% in the rural population, compared with 0.22% in the urban population. The anti-HCV positive rate in the 40–59-year age group was higher than in those aged <40 years. History of blood transfusion and transmission in families were the main risk factors for HCV infection in this area.ConclusionThe anti-HCV positive rate in Hebei has decreased significantly from that two decades ago. Safety of blood products and health education about HCV still need to be improved.

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“…Males showed a 1.2 times higher HCV infection rate than females, whereas other studies have reported equality between sexes or even female predominance in HCV infection (8,(20)(21)(22). The underlying reason of male predominance in this study is still not clear.…”

Section: Discussioncontrasting

confidence: 65%

Hepatitis C virus infection in the general population: A large community-based study in Mianyang, West China

Zhou

et al. 2015

BST

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A population-based study of the epidemiology of hepatitis C in a North American population

Cited by 21 publications

References 16 publications

Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey

Prevalence of hepatitis B and hepatitis C infection in Libya: results from a national population based survey

Epidemiology of Hepatitis C Virus Infection and Risk Factor Analysis in the Hebei Province, China

Hepatitis C virus infection in the general population: A large community-based study in Mianyang, West China

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