Hepatitis C virus infection in the general population: A large community-based study in Mianyang, West China

Zhou, Min; Li, Hong; Ji, Yulin; Ma, Yuanji; Hou, Fengsu; Yuan, Ping

doi:10.5582/bst.2015.01033

Cited by 13 publications

(19 citation statements)

References 33 publications

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“…This possibly due to improvements in medication and quality of life in recent years, especially the safety of blood transfusion. The rate was very close to the screening result of 157,168 people in Jiangsu province, where the total positive rate of anti-HCV was 0.79% [8]and the screening result of 438,575 people in the city of Mianyang, west China, where the total positive rate of anti-HCV was 0.80% [9].…”

Section: Discussionsupporting

confidence: 74%

“…Min et al reported that blood transfusion, surgery, or with a previous diagnosis of hypertension were significant risk factors for HCV infection in 2015 in the city of Mianyang [9]. A study by Yuliang Zhao in 2013 in Hebei Province found that history of blood transfusion and transmission in families, lived in rural area and aged 40-59, were significantly associated with HCV seropositivity [10].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of hepatitis C virus infection and risk factor analysis in Changsha, central China, about population undergoing routine check-up, 2013–2015

Liu

Zeng

Kang

et al. 2019

Preprint

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Background Currently, Hepatitis C virus (HCV) infection remains a major public health problem. The aim of current study wanted to determine the prevalence of HCV virus infections, and to explore the risk factors for HCV infection in the general adult population undergoing routine check-ups in Changsha City. Methods We collected 59688 blood samples from the adult population undergoing routine check-ups in 2013–2015 and obtained relevant information using a standardized questionnaire. We then conducted association and logistic regression analyses. We used the enzyme immunoassay method to test for anti-HCV antibodies in the serum samples. Results The positivity rate of anti-HCV was about 0.57% (340/59688) in the general population. Participants from rural areas showed significantly higher HCV seroprevalence rates than did those from the urban area (0.83% vs 0.19%, p < 0.001). HCV seropositivity increased progressively with age, peaking at 55–64 years (1.23%), and decreasing in participants aged 65 and older. The positivity rate of anti-HCV for males was slightly higher than that of females (0.67% vs 0.48%, p = 0.002). The results of multiple logistic regression showed that history of blood transfusion, surgery, living in rural areas, and transmission in families were the main risk factors for HCV infection. Conclusions: The prevalence of HCV infection is low in the general population in Changsha. This information vital for healthcare settings and health education entities in public, especially in rural areas.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis C virus infection and risk factor analysis in Changsha, central China, about population undergoing routine check-up, 2013–2015

Liu

Zeng

Kang

et al. 2019

Preprint

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“…HCV prevalence estimates were highly consistent across the three Chinese sites (0.4-0.6%) and compatible with estimates of 0.4-1.0% in large population-based surveys of women performed since 2006 [ 36 – 39 ]. HCV prevalence is especially low below age 45.…”

Section: Discussionsupporting

confidence: 70%

Hepatitis C virus seroprevalence in the general female population of 9 countries in Europe, Asia and Africa

Clifford

Waterboer

Dondog

et al. 2017

Infect Agents Cancer

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BackgroundNew oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-income countries (LMIC).MethodsBetween 2004 and 2009, dried blood spots were collected from age-stratified female population samples of 9 countries: China, Mongolia, Poland, Guinea, Nepal, Pakistan, Algeria, Georgia and Iran. HCV antibodies were detected by a multiplex serology assay using bead-based technology.ResultsCrude HCV prevalence ranged from 17.4% in Mongolia to 0.0% in Iran. In a pooled model adjusted by age and country, in which associations with risk factors were not statistically heterogeneous across countries, the only significant determinants of HCV positivity were age (prevalence ratio for ≥45 versus <35 years = 2.84, 95%CI 2.18-3.71) and parity (parous versus nulliparous = 1.73, 95%CI 1.02-2.93). Statistically significant increases in HCV positivity by age, but not parity, were seen in each of the three countries with the highest number of HCV infections: Mongolia, Pakistan, China. There were no associations with sexual partners nor HPV infection. HCV prevalence in women aged ≥45 years correlated well with recent estimates of female HCV-related liver cancer incidence, with the slight exception of Pakistan, which showed a higher HCV prevalence (5.2%) than expected.ConclusionsHCV prevalence varies enormously in women worldwide. Medical interventions/hospitalizations linked to childbirth may have represented a route of HCV transmission, but not sexual intercourse. Combining dried blood spot collection with high-throughput HCV assays can facilitate seroepidemiological studies in LMIC where data is otherwise scarce.

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“…In China, HCV infection ranks as the fourth most commonly reported infectious disease following hepatitis B virus, pulmonary tuberculosis, and dysentery, making China the country with the largest absolute number of HCV‐infected people (9.8 million) . Whereas HCV prevalence in the general population in China has been reported in recent studies, there are limited data on the HCV prevalence and incidence among Chinese blood donors. In a previous Recipient Epidemiology and Donor Evaluation Study‐II (REDS‐II) study (2008‐2010), we assessed HCV prevalence and incidence among Chinese blood donors at five regional blood centers based on results from the third‐generation Ortho HCV Enzyme‐Linked Immunosorbent Assay (ELISA) .…”

mentioning

confidence: 99%

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

Lv²,

Zhang³

et al. 2019

Transfusion

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were screened in parallel by two different enzyme-linked immunosorbent assays for anti-HIV 1/2, hepatitis B surface antigen, anti-HCV, and syphilis. Screeningreactive samples were further confirmed by western blot. Confirmatory positive rates among first-time and repeat donors were used to estimate the prevalence and incidence rates. Multivariable logistic regression modeling was used to examine factors associated with HCV infection. RESULTS:A total of 1,276,544 donations were collected from five Chinese blood centers, of which an estimated 1203 were confirmed HCV positive. The overall HCV prevalence among first-time donors was 166.56 per 100,000 donors (95% confidence interval, 156.04-177.08). The HCV incidence rate was estimated to be 15.21 (95% confidence interval, 11.83-19.56) per 100,000 person-years among repeat donors. Multivariable logistic regression results showed that increased age, lower educational levels, ethnicity, and occupation were all important factors associated with HCV confirmatory status among first-time donors (p < 0.01). CONCLUSIONS: HCV infection is still an importantconcern for transfusion safety in China. Our findings indicate that continued strong efforts are needed to monitor and control the risk of transfusion-transmitted HCV infection in China. Moreover, to reduce unnecessary donor loss, HCV donor screening procedures should be improved by incorporating confirmatory testing into routine blood center operations. From the

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Hepatitis C virus infection in the general population: A large community-based study in Mianyang, West China

Cited by 13 publications

References 33 publications

Prevalence of hepatitis C virus infection and risk factor analysis in Changsha, central China, about population undergoing routine check-up, 2013–2015

Prevalence of hepatitis C virus infection and risk factor analysis in Changsha, central China, about population undergoing routine check-up, 2013–2015

Hepatitis C virus seroprevalence in the general female population of 9 countries in Europe, Asia and Africa

Hepatitis C virus prevalence and incidence estimates among Chinese blood donors

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