A polysaccharide fromRosa roxburghiiTratt fruit attenuates high-fat diet-induced intestinal barrier dysfunction and inflammation in mice by modulating the gut microbiota

Abstract

Obesity-induced colonic inflammation-stimulated colitis is one of the main causes of colorectal cancer. Dietary polysaccharides are considered an effective agent for relieving obesity-induced inflammatory diseases such as diabetes and colitis....

Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model

“…Furthermore, studies have shown that the pro-inflammatory response mediated by the TLR4-MyD88 signaling pathway is linked to a number of other signaling pathways, including nuclear factor kappa B (NF-κB) pathway [35, 36]. We evaluated whether Au inhibited the release of pro-inflammatory mediators in microglia via the NF-κB pathway.…”

Arabinoxylan from rice bran protects mice against high-fat diet-induced obesity and metabolic inflammation by modulating gut microbiota and short-chain fatty acids

“…10 Both oligosaccharides and polysaccharides from different sources have been shown to have a lipolytic effect. 11,29–32 However, their effects on the gut microbiota depend on the chemical structure.…”

The combination of microbiome and metabolome to analyze the cross-cooperation mechanism ofEchinacea purpureapolysaccharide with the gut microbiotain vitroandin vivo

“…3E), the relative abundances of Muribaculaceae, Lachnospiraceae NK4A136, Lachnospiraceae UCG, Eubacterium xylanophilum, Lachnoclostridium, Butyricicoccus, Roseburia and Alloprevotella in the guts of mice in the EPP group were significantly changed compared with those in the guts of mice in the control group. Studies have found that prickly pear polysaccharides and hijiki polysaccharides can improve barrier dysfunction and inflammation in mice by increasing the relative abundance of Muribaculaceae, 36,37 suggesting that EPP may also strengthen the gut barrier. In addition, the abundances of the butyrateproducing microorganisms Eubacterium xylanophilum and Butyricicoccus were found to be reduced in the gut of EPP mice, 38 and the butyrate content of mice will be discussed later.…”