A polymer chip-integrable piezoelectric micropump with low backpressure dependence

Conde, Alvaro J.; Bianchetti, Arturo; Veiras, Francisco E.; Federico, Antonio; Cabaleiro, Juan Martin; Dufva, Martin; Madrid, Rossana E.; Fraigi, Liliana

doi:10.1039/c5ra08819d

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…31 Piezoelectrically actuated micropumps, utilizing piezoelectric diaphragms enable highly controllable pulsatile flows. 22,32 We envisage that the simplification of microfluidic technologies (in terms of fabrication, programming, and operation), along with minimizing their reliance on supporting equipment, 27,33−37 can accelerate their adoption in mechanobiology laboratories.…”

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confidence: 99%

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Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System

et al. 2019

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We describe a piezoelectric pumping system for studying the mechanobiology of human aortic endothelial cells (HAECs) under pulsatile flow in microfluidic structures. The system takes advantage of commercially available components, including pumps, flow sensors, and microfluidic channels, which can be easily integrated, programmed, and operated by cellular biologists. Proof-of-concept experiments were performed to elucidate the complex mechanotransduction processes of endothelial cells to pulsatile flow. In particular, we investigated the effect of atheroprone and atheroprotective pulsatile shear stress on endothelial cytoskeleton remodeling and distribution of β-catenin, as well as nuclear shape and size. The system is simple to operate, relatively inexpensive, portable, and controllable, providing opportunities for studying the mechanobiology of endothelial cells using microfluidic technologies.

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“…The harmonic movement of piezoelectric pins has also been employed to deform the elastomeric microfluidic channels, leading to the generation of customized pulsatile flows . Piezoelectrically actuated micropumps, utilizing piezoelectric diaphragms enable highly controllable pulsatile flows. , …”

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Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System

et al. 2019

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“…In order to tackle the limitations of previously reported bubble-based micromixers and taking inspiration from a previously reported hybrid microfluidic device, 26 we propose the hybrid approach illustrated in Fig. 1A.…”

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Versatile hybrid acoustic micromixer with demonstration of circulating cell-free DNA extraction from sub-ml plasma samples

et al. 2020

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“…According to whether there are valves, piezoelectric pumps can be divided into valve-less [7][8][9][10], with passive valves [11][12][13] and with active valves [14][15][16]. According to number of chambers, piezoelectric pumps can be divided into single-chamber [17,18] and multi-chamber [9,[14][15][16][19][20][21]. Moreover, due to structural characteristics, almost all piezoelectric pumps with active valves are multi-chamber piezoelectric pumps [14][15][16].…”

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A multi-chamber piezoelectric pump based on pumping unit with double circular piezoelectric unimorph actuators

Wang¹,

Peng²,

Tang³

et al. 2021

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For improving flow rate of multi-chamber piezoelectric pump with active valves, principle and structure of multi-chamber piezoelectric pump based on pumping unit with double circular piezoelectric unimorph actuators (CPUAs) are proposed. Double CPUAs are coaxially and symmetrically arranged on top and bottom of pump chamber and work in same frequency and phase at same time to provide driving force for pump. Two active piezoelectric valves with annular boundary are designed on left and right of pumping unit to ensure the multi-chamber piezoelectric pump bidirectionally pump fluid with high control accuracy and stop characteristics. Process compatible with printed circuit board (PCB) process is used to manufacture pump to ensure low cost. Flow rate model is established to numerically simulate flow characteristics of the pump. Pump is also experimentally tested and analyzed. Results show that proposed principle and structure can effectively improve flow rate and out pressure of multi-chamber piezoelectric pump with high control accuracy and stop characteristics of flow. Moreover, flow rate model can accurately describe its flow characteristics, which will be beneficial to design and optimize multi-chamber piezoelectric pumps with active valves. Proposed principle and structure of multi-chamber piezoelectric pumps with active valves have potential applications in complex microfluidic systems such as biochemical analysis, drug delivery and chip cooling.

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A polymer chip-integrable piezoelectric micropump with low backpressure dependence

Abstract: A polymer piezoelectric micropump fabricated with conventional machining methods that can be embedded in laminated microfluidic chips.

Cited by 11 publications

References 28 publications

Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System

Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System

Versatile hybrid acoustic micromixer with demonstration of circulating cell-free DNA extraction from sub-ml plasma samples

A multi-chamber piezoelectric pump based on pumping unit with double circular piezoelectric unimorph actuators

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