A polymer-based nano-resistive pulse sensor for detection of biomolecules: fabrication and simulation

Berkenbrock, José Alvim; Achenbach, Sven; Wells, Garth; Mail, Matthias; Scherer, Torsten

doi:10.1109/nano47656.2020.9183598

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…This is the signal that can get evaluated for detection, and which coined the term resistive pulse sensor. In recent decades, micro- and nanofabrication technologies have allowed minimizing the diameter of the pore, creating devices with potentially single-molecule sensitivity [ 70 , 124 , 127 , 128 ]. RPS-based detectors were used for single-virus identification for the diagnosis of influenza, with a discriminability above 95% between H1N1 and H3N2 when analysing the detection pattern for 20 virions or more [ 94 ].…”

Section: Detection Approaches Using Microfluidic Systemsmentioning

confidence: 99%

Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks

2020

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Extensive testing of populations against COVID-19 has been suggested as a game-changer quest to control the spread of this contagious disease and to avoid further disruption in our social, healthcare and economical systems. Nonetheless, testing millions of people for a new virus brings about quite a few challenges. The development of effective tests for the new coronavirus has become a worldwide task that relies on recent discoveries and lessons learned from past outbreaks. In this work, we review the most recent publications on microfluidics devices for the detection of viruses. The topics of discussion include different detection approaches, methods of signalling and fabrication techniques. Besides the miniaturization of traditional benchtop detection assays, approaches such as electrochemical analyses, field-effect transistors and resistive pulse sensors are considered. For emergency fabrication of quick test kits, the local capabilities must be evaluated, and the joint work of universities, industries, and governments seems to be an unequivocal necessity.

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