A polyethylenimine-based diazeniumdiolate nitric oxide donor accelerates wound healing

Zhang, Yan; Tang, Keyu; Chen, Bin; Zhou, Shui‐Hong; Li, Nan; Liu, Chuwei; Yang, Jun; Lin, Run; Zhang, Tao; He, Weiling

doi:10.1039/c8bm01519h

Cited by 41 publications

(46 citation statements)

References 33 publications

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“…[11] Additionally, therapeutic administration of low molecular weight NO donors may result in accelerated clearance (i.e., rapid diffusion away from the target and concomitant reduced therapeutic activity for cancer, CVD, and bacteria. [7b] To increase the stabilities, and to optimize the pharmacokinetic performance, NONOates [3,66] and SNOs were generally incorporated into various polymeric delivery systems in terms of linear, star, and dendritic polymers, as well as, MOF, mesoporous silica NPs, micelles, and liposomes. [67] Loading NO donors into polymeric delivery systems usually depends on the NO donor properties such as surface charge, hydrophobicity and functional groups.…”

Section: Polymeric No Delivery Nanoplatformsmentioning

confidence: 99%

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Jin

Gao

Liu

et al. 2020

Adv Healthcare Materials

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The shortened Abstract is as follows: Therapeutic gas nitric oxide (NO) has demonstrated the unique advances in biomedical applications due to its prominent role in regulating physiological/pathophysiological activities in terms of vasodilation, angiogenesis, chemosensitizing effect, and bactericidal effect. However, it is challenging to deliver NO, due to its short half-life (<5 s) and short diffusion distances (20-160 µm). To address these, various polymeric NO delivery nanoplatforms (PNODNPs) have been developed for cancer therapy, antimicrobial and cardiovascular therapeutics, because of the important advantages of polymeric delivery nanoplatforms in terms of controlled release of therapeutics and the extremely versatile nature. This reviews highlights the recent significant advances made in PNODNPs for NO storing and targeting delivery. The ideal and unique criteria that are required for PNODNPs for treating cancer, cardiovascular diseases and infection, respectively, are summarized. Hopefully, effective storage and targeted delivery of NO in a controlled manner using PNODNPs could pave the way for NO-sensitized synergistic therapy in clinical practice for treating the leading death-causing diseases.

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Section: Polymeric No Delivery Nanoplatformsmentioning

confidence: 99%

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Jin

Gao

Liu

et al. 2020

Adv Healthcare Materials

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“…Therefore, NONOate is a kind of very important NO local release compounds. Researchers have developed NONOate macromolecule by developing amine-containing polymeric matrices to control the release of small molecule NONOates effectively (Zhang et al, 2019). These compounds have been widely explored in biomedical fields to show outstanding clinical application prospects.…”

Section: Diazeniumdiolatesmentioning

confidence: 99%

Recent Developments in Pharmacological Effect, Mechanism and Application Prospect of Diazeniumdiolates

Ming

Liu

et al. 2020

Front. Pharmacol.

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Nitric oxide (NO) is a simple structured and unstable free radical molecule, which participates in the regulation of many pathophysiological processes. It functions both as a second messenger and as an endogenous neurotransmitter. Diazeniumdiolates (NONOates) are a series of compounds containing the functional parent nuclear structure of [N(O)NO] -, which are the most widely studied NO donors. NONOates are unstable and easy to release NO in physiological conditions. The biomedical applications and drug development of NO donor have attracted the scientists' attention in recent years. In this review, recent advances in NONOates research are highlighted in terms of chemical structures, molecular characteristics, pharmacological effects, and biomedical application prospects.

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“…In a recent study, propylene oxide was used to functionalized with hyperbranched PEI with the formation of hydroxyl moieties and the residual amine groups was treated with NO. In vivo study on mice revealed that the resulting macromolecular NO donors exhibited accelerated wound healing performance in full thickness excisional cutaneous wound model (Zhang et al, 2019). The PEI-derived NONOate-based NO donors can also be used as the stabilizing agents of inorganic nanoparticles.…”

Section: N-diazeniumdiolate (Nonoate)-based Polymeric No Donorsmentioning

confidence: 99%

Nitric Oxide (NO)-Releasing Macromolecules: Rational Design and Biomedical Applications

Cheng

Shen

et al. 2019

Front. Chem.

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Nitric oxide (NO) has been recognized as a ubiquitous gaseous transmitter and the therapeutic potential has nowadays received increasing interest. However, NO cannot be easily directly administered due to its high reactivity in air and high concentration-dependent physiological roles. As such, a plethora of NO donors have been developed that can reversibly store and release NO under specific conditions. To enhance the stability and modulate the NO release profiles, small molecule-based NO donors were covalently linked to polymeric scaffolds, rendering them with multifunctional integration, prolonged release durations, and optimized therapeutic outcomes. In this minireview, we highlight the recent achievements of NO-releasing macromolecules in terms of chemical design and biomedical applications. We hope that more efforts could be devoted to this emerging yet promising field.

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A polyethylenimine-based diazeniumdiolate nitric oxide donor accelerates wound healing

Abstract: A polyethylenimine based diazeniumdiolate nitric oxide donor was prepared to accelerate wound healing.

Cited by 41 publications

References 33 publications

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Recent Developments in Pharmacological Effect, Mechanism and Application Prospect of Diazeniumdiolates

Nitric Oxide (NO)-Releasing Macromolecules: Rational Design and Biomedical Applications

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