A Polydopamine Nanoparticle-Knotted Poly(ethylene glycol) Hydrogel for On-Demand Drug Delivery and Chemo-photothermal Therapy

Abstract

Hydrogels have exhibited remarkable benefits in drug delivery such as local delivery, days or even weeks of continuous drug release with improved bioavailability, and minimized adverse effects.Here we report a polydopamine (PDA) nanoparticle-knotted poly(ethylene glycol) (PEG) hydrogel for on-demand drug delivery and combined chemo-photothermal therapy. Anticancer drugs such as 7-ethyl-10-hydroxycamptothecin (SN38) loaded on PDA nanoparticles via π−π interaction in the gel exhibit minimal leakage at physiological conditions and could be released in an on-demand fashion upon near-infrared light exposure. The hydrogel shows excellent biocompatibility and does not induce any foreign-body reaction over a four-month implantation. The in vivo results demonstrate that the PDA nanoparticle-knotted PEG hydrogel loaded with SN38 could efficiently suppress tumor growth by a combined chemo-photothermal therapy. This smart hydrogel would benefit a series of local treatments for diverse diseases.

Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise

“…To further improve the tumor accumulation efficacy of nanocomposites, RGD peptide and lactose functionalized PDA NPs have been designed for tumor active targeting and chemo‐photothermal combination therapy 97. In addition to PDA NPs, hollow PDA capsules, PDA‐knotted poly(ethylene glycol) hydrogels, and PDA/mesoporous calcium phosphate hollow Janus nanoparticles ( Figure ) have been innovatively developed as nanocarriers for PAI‐guided chemo‐phototherapy, exhibiting synergistic antitumor activity in vivo compared with the respective counterpart 98…”

“…Abbreviations: H‐JNPs, hollow Janus nanoparticles; PAA, poly (acrylic acid); mCaP, mesoporous calcium phosphate; DOX, doxorubicin. Reproduced with permission 98b. Copyright 2017, Royal Society of Chemistry.…”

Nanomaterials for Cardiac Tissue Engineering

“…This chemical versatility has been utilized to conjugate many different molecules onto PDA and related catecholamine materials over the years, such as DNA [88], PEG [85], hydroxyapatite for biomineralization [89], and RGD peptides for cell attachment [90]. PDA has also been formulated into nanoparticles, retaining these properties for facile modification while also demonstrating antioxidant activity [91][92][93][94][95].…”

Antibacterial poly (3,4-ethylenedioxythiophene):poly(styrene-sulfonate)/agarose nanocomposite hydrogels with thermo-processability and self-healing

“…Recently, near-infrared (NIR) laser-induced photothermal therapy has proven to be a versatile, powerful tool to combat cancer and bacterial infection (Chen, Fang, Tang, & Zheng, 2012;Chen, Tang, Tang, & Li, 2017;Chen et al, 2016;Wang et al, 2017;Wu, Deokar, Liao, Shih, & Ling, 2013;Yang et al, 2011;Zhang et al, 2018). NIR irradiation in the range of 700−1100 nm has a particularly large advantage in biological applications because it is deeply penetrable into tissues and is nearly harmless to living tissues, while ultraviolet (UV) is not (Boas, Elwell, Ferrari, & Taga, 2014;Ferrari & Quaresima, 2012;Manley, 2014).…”