A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

Li, Yan; He, Hai; Lü, Wan-Liang; Jia, Xinru

doi:10.1039/c7ra00713b

Cited by 31 publications

(18 citation statements)

References 52 publications

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“…These peaks, however, merge into a broad absorption peak upon conjugation as displayed in Figure 4 . The characteristic absorption of the amide bonds also got red shifted to 1630 cm −1 and 1550 cm −1 as previously reported [ 24 , 25 ].…”

Section: Resultssupporting

confidence: 86%

“…The FTIR spectra of the dyes as displayed in Figure 4 verify that the DL680 dye was successfully conjugated to the Eu-G5PAMAM nanoparticle. As shown in prior studies, PAMAM dendrimer exhibits peaks at 3286 and 3345 cm −1 corresponding to the primary amino groups on the surface of the dendrimer [ 24 , 25 ]. These peaks, however, merge into a broad absorption peak upon conjugation as displayed in Figure 4 .…”

Section: Resultsmentioning

confidence: 76%

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Dendrimer-based Nanoparticle for Dye Sensitized Solar Cells with Improved Efficiency

Ghann

Kang

Uddin

et al. 2018

J Nanomed Nanotechnol

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Dye sensitized solar cells were fabricated with DyLight680 (DL680) dye and its corresponding europium conjugated dendrimer, DL680-Eu-G5PAMAM, to study the effect of europium on the current and voltage characteristics of the DL680 dye sensitized solar cell. The dye samples were characterized by using Absorption Spectroscopy, Emission Spectroscopy, Fluorescence lifetime and Fourier Transform Infrared measurements. Transmission electron microscopy imaging was carried out on the DL680-Eu-G5PAMAM dye and DL680-Eu-G5PAMAM dye sensitized titanium dioxide nanoparticles to analyze the size of the dye molecules and examine the interaction of the dye with titanium dioxide nanoparticles. The DL680-Eu-G5PAMAM dye sensitized solar cells demonstrated an enhanced solar-to-electric energy conversion of 0.32% under full light illumination (100 mWcm−2, AM 1.5 Global) in comparison with that of DL680 dye sensitized cells which recorded an average solar-to-electric energy conversion of only 0.19%. The improvement of the efficiency could be due to the presence of the europium that enhances the propensity of dye to absorb sunlight.

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Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 76%

Dendrimer-based Nanoparticle for Dye Sensitized Solar Cells with Improved Efficiency

Ghann

Kang

Uddin

et al. 2018

J Nanomed Nanotechnol

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“…Results revealed that the entrapped drug in PEGylated PAMAM dendrimer was higher than that of naked PAMAM dendrimer [31]. In terms of toxicity reduction, Li Y. et al proved that substitution of amino surface groups of PAMAM G4.0 with PEG can remarkably reduce its cytotoxicity [32]. A similar phenomenon can also be seen in the study of D’Emanuele A. et al [33].…”

Section: Introductionmentioning

confidence: 75%

Partial Surface Modification of Low Generation Polyamidoamine Dendrimers: Gaining Insight into their Potential for Improved Carboplatin Delivery

et al. 2019

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Carboplatin (CAR) is a second generation platinum-based compound emerging as one of the most widely used anticancer drugs to treat a variety of tumors. In an attempt to address its dose-limiting toxicity and fast renal clearance, several delivery systems (DDSs) have been developed for CAR. However, unsuitable size range and low loading capacity may limit their potential applications. In this study, PAMAM G3.0 dendrimer was prepared and partially surface modified with methoxypolyethylene glycol (mPEG) for the delivery of CAR. The CAR/PAMAM G3.0@mPEG was successfully obtained with a desirable size range and high entrapment efficiency, improving the limitations of previous CAR-loaded DDSs. Cytocompatibility of PAMAM G3.0@mPEG was also examined, indicating that the system could be safely used. Notably, an in vitro release test and cell viability assays against HeLa, A549, and MCF7 cell lines indicated that CAR/PAMAM G3.0@mPEG could provide a sustained release of CAR while fully retaining its bioactivity to suppress the proliferation of cancer cells. These obtained results provide insights into the potential of PAMAM G3.0@mPEG dendrimer as an efficient delivery system for the delivery of a drug that has strong side effects and fast renal clearance like CAR, which could be a promising approach for cancer treatment.

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“…In traditional electrically-assisted drug delivery systems (iontophoresis), electrodes are placed on the surface and a field is applied 47 . The simplicity of the Voltaglue electroceutical patch allows expansion into drug-depot applications, where the combination of gradient curing, dendrimer grafting and current transduction may be engineered for passive and on-demand drug delivery systems [48][49][50][51] . The strength of the electric field diminishes from the semiconductor surface.…”

Section: Soluble Leachate Determines Half Of the Mass Is Not Crosslin...mentioning

confidence: 99%

Voltaglue Electroceutical Adhesive Patches for Localized Voltage Stimulation

Singh

Webster

Steele

2019

ACS Appl. Bio Mater.

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Electroceuticals have been proposed as nerve-and tissue-stimulating therapeutics for diverse ailments such as fracture repair, Parkinson's disease, diabetes, hypertension, and wound healing. However, academic and clinical investigation of electroceutical hypotheses remains intangible due to lack of suitable interfaces required for the application of uniform electric fields to localized tissues. There is an unmet need to develop materials that match the mechanical properties of soft tissues, are electrically conductive, and can flex to accommodate body movements. Herein, the design of a flexible resistive substrate and voltage-activated adhesive-

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A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

Cited by 31 publications

References 52 publications

Dendrimer-based Nanoparticle for Dye Sensitized Solar Cells with Improved Efficiency

Dendrimer-based Nanoparticle for Dye Sensitized Solar Cells with Improved Efficiency

Partial Surface Modification of Low Generation Polyamidoamine Dendrimers: Gaining Insight into their Potential for Improved Carboplatin Delivery

Voltaglue Electroceutical Adhesive Patches for Localized Voltage Stimulation

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