A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery

Gratieri, Taís; Rocha, Eduardo Melani; Sarmento, Víctor Hugo Vitorino; Freitas, Osvaldo de; Lopez, Renata Fonseca Vianna

doi:10.1016/j.ejpb.2010.02.011

Cited by 295 publications

(176 citation statements)

References 58 publications

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“…Stimulation to the ocular tissues may occur on increasing the concentration of Carbopol in the formulation, thus to reduce its concentration and to achieve better gelation combination of Carbopol and methylcellulose has been used as ocular drug delivery system [44].…”

Section: Combination Of Polymers Having Different Gelation Mechanismsmentioning

confidence: 99%

“…Gratieri et al [44], developed a thermosetting polymer, Poloxamer and mucoadhesive agent chitosan based in situ gelling system with improved mechanical and mucoadhesive properties for prolonged ocular retention and treatment of ocular diseases. Chitosan was observed to improve the mechanical strength and texture properties of Poloxamer formulations and also confers mucoadhesive properties in a concentration dependent manner.…”

Section: Combination Of Polymers Having Different Gelation Mechanismsmentioning

confidence: 99%

“…Chitosan was observed to improve the mechanical strength and texture properties of Poloxamer formulations and also confers mucoadhesive properties in a concentration dependent manner. Poloxamer-chitosan (16:1) formulation showed optimum gelation temperature 32°C and four fold increased retention in the human eyes as compared to the conventional solution suggesting the increased retention of the gel at the corneal surface [44].…”

Section: Combination Of Polymers Having Different Gelation Mechanismsmentioning

confidence: 99%

See 2 more Smart Citations

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Jain¹,

Kumar²,

Singh³

et al. 2016

JAPLR

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In situ -gelling systems has the great potential in the wide areas of drug delivery. The application areas of such systems are broad and these systems can be formulated not only as gels but also as in situ gelling nanospheres, microspheres and liposomes. To overcome the drawbacks associated with conventional drug delivery systems and take advantages of both solutions and gels, such as accurate dosing, ease of administration of the former and longer precorneal residence of the latter, a newer concept of in situ gelling drug delivery systems was came in light for the first time in the early 1980s. In situ gelling systems are the polymeric solutions which can be administered in solution form and immediately undergoes sol-gel phase transition in to a viscoelastic gel upon exposure to physiological conditions (e.g. pH, temperature and ionic concentration) or application of external triggers. In situ gelling systems seems to have wide applications in ocular therapy. A lot of research is going on in this area proves the fact that in situ gelling systems can be advantageous in the ocular drug delivery. In the present review we will discuss recent researches involving application of in situ gelling polymers, their applications in the various domains of drug delivery and marketed formulations based on in situ gelling systems.

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Section: Combination Of Polymers Having Different Gelation Mechanismsmentioning

confidence: 99%

Section: Combination Of Polymers Having Different Gelation Mechanismsmentioning

confidence: 99%

Section: Combination Of Polymers Having Different Gelation Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Jain¹,

Kumar²,

Singh³

et al. 2016

JAPLR

View full text Add to dashboard Cite

show abstract

“…The viscosity measurements were made in triplicate using fresh samples each time. 29 Mucoadhesion study 30 Mucoadhesion study was carried out using modified mucoadhesion apparatus. There was two glass slides, bottom slide was fixed with wooden base while upper slide was attached to nylon thread, and the other end of nylon thread was attached to plastic bowl.…”

Section: Evaluation Of In-situ Gelmentioning

confidence: 99%

Formulation Development and Evaluation of a Gastroretentive in situ oral gel of Cefuroxime Axetil

Shastri¹,

Dodiya²,

Shelat³

et al. 2016

JYP

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“…Though thermo sensitive copolymers are employed widely, they suffer from a major drawback of having weak mechanical strength, which leads to rapid erosion of polymer 10 . This problem can be solved by using blends of poloxamers with chitosan 11 . Chitosan, a natural polysaccharide derived from naturally abundant chitin, having excellent ocular compatibility [12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Formulation and Assessment of Gemifloxacin Mesylate Ocular in Situ Gelling System

Rajalakshmi¹,

C²,

Radhika³

et al. 2013

Int. Res. J. Pharm.

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In situ gels are one of the most successful means of delivering the drug at ocular site with maximum bioavailability, which undergoes gelation upon instillation as drops into the eye due to physicochemical changes inherent to the biological fluids. The main aim of the present investigation was to obtain an ophthalmic drug delivery system with improved mucoadhesive and mechanical properties that could provide extended retention time for the treatment of ocular infections. For this in situ gels of Gemifloxacin Mesylate comprised of the combination of a thermosetting polymer, polaxamer with a mucoadhesive agent chitosan was developed. Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry techniques (DSC) were performed to know the compatibilities between drug and polymer. FTIR spectra and DSC thermograph of Gemifloxacin Mesylate formulations showed that there is no chemical interaction between drug and polymer and confirmed the stability of the drug. The gels were evaluated for pH, Gel strength, Gelling capacity, Rheology, Drug content uniformity and Ocular irritancy studies. In vitro drug release studies reveal that all the formulations showed sustained release of the drug in the range of 70.82 to 76.43 % for a period of 8 h. The optimized formulation was tested for ocular irritation study on male albino rabbit and the result indicated that the formulation was well tolerated, non-irritating and therapeutically efficacious. In conclusion in situ gelling systems containing polaxamer / chitosan solution are viable alternative to enhance bioavailability thus leads to an excellent potential alternative ophthalmic sustained-release formulation of Gemifloxacin Mesylate in ocular infections.

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A poloxamer/chitosan in situ forming gel with prolonged retention time for ocular delivery

Cited by 295 publications

References 58 publications

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Newer Trends in In Situ Gelling Systems for Controlled Ocular Drug Delivery

Formulation Development and Evaluation of a Gastroretentive in situ oral gel of Cefuroxime Axetil

Formulation and Assessment of Gemifloxacin Mesylate Ocular in Situ Gelling System

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