2007
DOI: 10.1515/cclm.2007.250
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A plea for intra-laboratory reference limits. Part 2. A bimodal retrospective concept for determining reference limits from intra-laboratory databases demonstrated by catalytic activity concentrations of enzymes

Abstract: Poor reproducibility of IGT and IFG classification suggests caution should be exercised when interpreting a single test result.

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Cited by 101 publications
(75 citation statements)
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“…The reproducibility of an OGTT may be reduced due to variation in the quality of the glucose measurements as well as intraindividual variations. In a systematic review of five studies, the reproducibility of a single test was 33–45% for IGT, 51–64% for IFG, and 73% for diabetes (Balion et al 2007). Another reason for low reproducibility and misclassification is regression to the mean (Yudkin and Stratton 1996), indicating that individuals selected because they have a single high measurement will include a disproportionate number of individuals whose measurement by chance was higher than its true value.…”
Section: Discussionmentioning
confidence: 99%
“…The reproducibility of an OGTT may be reduced due to variation in the quality of the glucose measurements as well as intraindividual variations. In a systematic review of five studies, the reproducibility of a single test was 33–45% for IGT, 51–64% for IFG, and 73% for diabetes (Balion et al 2007). Another reason for low reproducibility and misclassification is regression to the mean (Yudkin and Stratton 1996), indicating that individuals selected because they have a single high measurement will include a disproportionate number of individuals whose measurement by chance was higher than its true value.…”
Section: Discussionmentioning
confidence: 99%
“…These cutoff values, derived from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study, predict adverse pregnancy outcomes with an odds ratio of 1.75 [18]. Challenges associated with using the IADPSG criteria for GDM diagnosis include a high prevalence of GDM (17.8% of all pregnancies in the HAPO study) and poor reproducibility [19]. Currently, both the Korean Diabetes Association and the American Diabetes Association (ADA) recommend both the one- and two-step approaches for the diagnosis of GDM [20,21].…”
Section: Diagnosis Of Gdm and Postpartum Diabetesmentioning
confidence: 99%
“…In this issue of Clinical Chemistry and Laboratory Medicine, two articles by Haeckel et al, the start of an announced series, try to bring concrete solutions and new light on this problem (7,8). The first article of the series is clear and educational (7).…”
Section: Interpretation Of Laboratory Results: the Reference Intervalmentioning
confidence: 99%
“…It necessitates extensive resources, notably the ready availability of a consistent database to allow implementation of the required selection criteria. The limits of such an approach appear obvious in reading their second article (8). The observed differences between laboratories' Reference Intervals are attributed to the population, but could, among other things, be due to inappropriate selection of the reference population.…”
Section: Interpretation Of Laboratory Results: the Reference Intervalmentioning
confidence: 99%