A platform for nitric oxide delivery

Breath sensors for lung cancer diagnosis

“…8. The cyclic response levels of pristine WO 3 nanofibers (NFs) and Pd-NPs/Pd-embedded WO 3 NFs for low concentration of toluene at 350°C and relative humidity 90% atmosphere (Kim et al, 2014). The inset highlights the concentration dependent response of pristine WO 3 NFs and Pd-NPs/Pd-embedded WO 3 NFs.…”

“…Still, semiconductor metal oxide sensors are advantageous among most of the other breath sensor types, due to their high gas responses, response speeds, stabilities, and lower costs (Kim et al, 2014). Kim and co-workers obtained superior toluene response (Rair/Rgas ¼5.5 at 1 ppm) and crosssensitivity against H 2 S (Rair/Rgas ¼1.36 at 1 ppm) by using a functionalized semiconductor metal oxide sensor (Kim et al, 2014). It was based on Pd catalysts inside and/or outside of semiconducting metal oxide WO 3 nanofibers.…”

Gasotransmitter delivery via self-assembling peptides: Treating diseases with natural signaling gases

“…To deliver NO for prolonged periods, many different NO donors have been investigated, including organic nitrates, nitrites, metal-NO complexes, nitrosamines, N-diazeniumdiolates (NONOates), and Snitrosothiols (RSNOs) [68]. Their relative advantages and disadvantages have been recently reviewed [69]. Among these, NONOates and RSNOs are the most widely studied NO donors due to their spontaneous release characteristics ( Figure 6).…”

Ruthenium nitrosyl grafted carbon dots as a fluorescence-trackable nanoplatform for visible light-controlled nitric oxide release and targeted intracellular delivery

“…Various types of exogenous NO-donors have been prepared and applied to biological systems, including metal nitrosyls [5][6][7][8][9] and organic donors [10][11][12][13][14][15][16][17] such as organic nitrites (RONO) and nitrates (RONO 2 ), diazeniumdiolates (NONOates), and S-nitrosothiols (RSNO). Compared with NO donors themselves, NO-donor-decorated nanoplatforms may increase the duration of drug circulation in the blood, allowing a reduction in the dose required to achieve therapeutic levels over an extended period of time.…”