A plasmon-enhanced fluorescent gold coated novel lipo-polymeric hybrid nanosystem: synthesis, characterization and application for imaging and photothermal therapy of breast cancer

Appidi, Tejaswini; Rajalakshmi, P.; Chinchulkar, Shubham Arunrao; Pradhan, Arpan; Begum, Hajira; Shetty, Veeresh; Srivastava, Rohit; Ganesan, Prabhusankar; Rengan, Aravind Kumar

doi:10.1039/d2nr01378a

Cited by 16 publications

(15 citation statements)

References 62 publications

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“…In another study, AuNP-liposome nanocomposite (150-200 nm) have been prepared and illustrated a good CT contrast with better signals compared to commercially available AuNP (15 and 40 nm) (Figure 8), and thus proposing a novel approach for cancer imaging [173]. Similarly, the signal from AuNP-liposome nanocomposite was strong and stable inside the tumor after injection, signifying the potential stability and tissue retention of the construct [174,175].…”

Section: Imagingmentioning

confidence: 93%

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Idoudi

Ismail

Rachid

et al. 2023

JNT

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Gold nanoparticles (AuNP) have received a growing attention due to their fascinating physiochemical properties and promising range of biomedical applications including sensing, diagnosis and cancer photothermal ablation. AuNP enjoy brilliant optical properties and ability to convert light into local heat and function as a “nanoheaters” to fight cancer. However, AuNP are poor drug delivery systems as they do not have reservoirs or matrices to achieve an acceptable drug loading efficiency. On the other end, liposome-based nanocarriers do not exhibit such optical properties but are excellent platform for drug loading and they have been proven clinically with a true presence in the market since the FDA approved Doxil® in 1995. Combining the brilliant optical and photothermal properties of AuNP with the excellent drug loading capability of liposome should yield nanocomposites that enjoy the features of both modalities and enable the development of novel and smart drug delivery systems. Therefore, this review discusses the up-to date research on the AuNP-liposome nanocomposites and the current available approaches and protocols for their preparation and characterization. Finally, the biomedical applications of AuNP-liposome nanocomposites and proposed future directions in this field are discussed.

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Section: Imagingmentioning

confidence: 93%

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Idoudi

Ismail

Rachid

et al. 2023

JNT

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“…Appidi et al reported PDPC NPs, a lipo-polymeric hybrid nanoparticles surface coated with Au (PDPC-co-loaded with IR780 (PDPC-IR-Au NPs) with HD d of 94.2 ± 14.9 nm. The nanosystem exhibited plasmon-enhanced fluorescence, demonstrating a heightened intracellular ROS, inducing DNA damage and apoptosis when tested against MCF-7 breast cancer cells 66 .…”

Section: Bio-nanomaterials Used For Pttmentioning

confidence: 99%

Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer

Beniwal,

Verma,

Putta

et al. 2024

Nanotheranostics

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In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally. Photothermal therapy (PTT) is one of the novel ways to treat and abolish cancer. PTT significantly impacts cancer theranostics compared to other therapies like surgery, chemotherapy, and radiotherapy due to its remarkable binding capability to tumor sites and lower invasiveness into normal healthy tissues. PTT relies on photothermal agents (PTAs), which generate heat by absorbing the near-infrared (NIR) light and destroying cancer cells. Several PTT agents remain longer in the reticuloendothelial system (RES) and induce toxicity, restricting their use in the biomedical field. To overcome this problem, the usage of biodegradable nano-photothermal agents is required. This review has discussed the PTT mechanism of action and different types of novel bio-nanomaterials used for PTT. We also focussed on the combinatorial effects of PTT with other cancer therapies and their effect on human health. The role of LED lights and mild hypothermia in PTT has been discussed briefly in this review.

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“…Prospective nanomaterials employed as smart delivery platforms of distinct biopesticides and development of NBPs. − …”

Section: Nanobiopesticides: An Efficient Biodegradable Approach For P...mentioning

confidence: 99%

Bacteria-Premised Nanobiopesticides for the Management of Phytopathogens and Pests

Padmakumar

Chowdary

Eswar

et al. 2023

ACS Agric. Sci. Technol.

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Rising awareness of the risks regarding chemical formulations and the surging need for eco-friendly inputs in sustainable agriculture have driven the use of bacterial biocontrol agents to the frontline of plant protection. Bacterial biocontrol agents (BBCAs) have been preferred as feasible alternatives to synthetic formulations due to their increased specificity and safety. Nanotechnology has facilitated the better addressing of product development and performance concerns related to BBCAs. Leveraging nanotechnology in the synthesis of novel nanomaterials with amended properties at the nanoscale has offered efficient and ecologically sound nanoformulations such as nanobiopesticides. The nanobiopesticides of bacterial origin, known as bacteria premised nanobiopesticides (B-NBPs), are efficient alternatives to agrochemicals. The B-NBPs include living or nonliving bacterial nanoformulations or nanoparticles synthesized using bacteria (BNPs) as the nanofactories. The B-NBPs were synthesized using high-pressure homogenization (HPH), jet milling, and hammer milling, giving rise to competent bacterial nanoformulations of size ranging from 250 to 500 nm. Following an overview of bacteria-based nanobiopesticides (B-NBPs) employed to prevent/treat plant diseases, the article highlights the role of BBCA's role in plant protection as well as its antagonistic mechanisms. Further, the concept of B-NBPs, concentrating on Bacillus thuringensis-driven forms, is reviewed. The review then briefly explains the significance of BNPs in plant infection management. Finally, the concerns related to the efficacy of B-NBPs along with the prospects are also described.

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A plasmon-enhanced fluorescent gold coated novel lipo-polymeric hybrid nanosystem: synthesis, characterization and application for imaging and photothermal therapy of breast cancer

Abstract: This study reports the synthesis and application of a hybrid lipo-polymeric nanosystem (PDPC NPs) for plasmon enhanced flourescence based NIR imaging and photothermal therapy.

Cited by 16 publications

References 62 publications

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

The Golden Liposomes: Preparation and Biomedical Applications of Gold-Liposome Nanocomposites

Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer

Bacteria-Premised Nanobiopesticides for the Management of Phytopathogens and Pests

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