A Placebo-Controlled Randomized Crossover Trial of the N-Methyl-d-Aspartic Acid Receptor Antagonist, Memantine, in Patients with Chronic Phantom Limb Pain

Adjuvant analgesics are defined as drugs with a primary indication other than pain that have analgesic properties in some painful conditions. The group includes numerous drugs in diverse classes. Although the widespread use of these drugs as first-line agents in chronic nonmalignant pain syndromes suggests that the term "adjuvant" is a misnomer, they usually are combined with a less-than-satisfactory opioid regimen when administered for cancer pain. Some adjuvant analgesics are useful in several painful conditions and are described as multipurpose adjuvant analgesics (antidepressants, corticosteroids, α α 2 -adrenergic agonists, neuroleptics), whereas others are specific for neuropathic pain (anticonvulsants, local anesthetics, N-methyl-D-aspartate receptor antagonists), bone pain (calcitonin, bisphosphonates, radiopharmaceuticals), musculoskeletal pain (muscle relaxants), or pain from bowel obstruction (octreotide, anticholinergics). This article reviews the evidence supporting the use of each class of adjuvant analgesic for the treatment of pain in cancer patients and provides a comprehensive outline of dosing recommendations, side effects, and drug interactions. The Oncologist 2004;9:571-591

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“…Although it could theoretically possess some analgesic properties, controlled trials published so far have been disappointing [90,91].…”

Section: N-methyl-d-aspartate Receptor Blockersmentioning

confidence: 99%

Adjuvant Analgesics in Cancer Pain Management

2004

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“…Previous studies on the treatment of phantom limb pain with Memantine reported normalization of cortical reorganization: displaced or enlarged somatotopic representation of the painful limb was successfully reversed after treatment. 19,20 There is increasing evidence that cortical reorganization is causally involved in the maintenance of chronic neuropathic pain. 21,22 The aim of this study was to demonstrate a CNS contribution in the development and preservation of CRPS.…”

mentioning

confidence: 99%

Memantine Treatment of Complex Regional Pain Syndrome

Sinis

Birbaumer²,

Gustin

et al. 2007

The Clinical Journal of Pain

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“…Entre sus indicaciones se han propuesto: dolor neuropático oncológico, neuralgia postherpética, traumatismo crónico, amputación, lesión de la ME, dolor de origen central secundario a accidente cerebrovascular, dolor de miembro fantasma, síndrome de piernas inquietas, dolor crónico orofacial, fibromialgia y dolor postquirúrgico, entre otros (13,23,24,30,31).…”

Section: Indicacionesunclassified

La ketamina en el tratamiento del dolor crónico según medicina basada en la evidencia.

Reina¹,

García²,

Ortega³

2016

Rev. Soc. Esp. Dolor.

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Título:La ketamina en el tratamiento del dolor crónico según medicina basada en la evidencia. Autores:FERNANDO NEIRA REINA, Josefa Luisa Ortega García, Beatriz Neira Ortega DOI: 10.20986/resed.2016DOI: 10.20986/resed. .3462/2016 Instrucciones de citación para el artículo: NEIRA REINA FERNANDO, Ortega García Josefa Luisa, Neira Ortega Beatriz. La ketamina en el tratamiento del dolor crónico según medicina basada en la evidencia.. Rev. Soc. Esp. Dolor. 2016Dolor. . doi: 10.20986/resed.2016Dolor. .3462/2016 Este es un archivo PDF de un manuscrito inédito que ha sido aceptado para su publicación en la Revista de la Sociedad Española del Dolor. Como un servicio a nuestros clientes estamos proporcionando esta primera versión del manuscrito en estado de prepublicación. El manuscrito será sometido a la corrección de estilo final, composición y revisión de la prueba resultante antes de que se publique en su forma final. Tenga en cuenta que durante el proceso de producción se pueden dar errores lo que podría afectar el contenido final. El copyright y todos los derechos legales que se aplican al artículo pertenecen a la Revista de la

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A Placebo-Controlled Randomized Crossover Trial of the N-Methyl-d-Aspartic Acid Receptor Antagonist, Memantine, in Patients with Chronic Phantom Limb Pain

Abstract: NMDA receptors play a substantial role in central nervous system changes underlying neuropathic pain. In a placebo-controlled double-blinded study we tested the effect of 30 mg memantine on chronic phantom limb pain and pain-associated cortical reorganization.

Cited by 106 publications

References 42 publications

Adjuvant Analgesics in Cancer Pain Management

Adjuvant Analgesics in Cancer Pain Management

Memantine Treatment of Complex Regional Pain Syndrome

La ketamina en el tratamiento del dolor crónico según medicina basada en la evidencia.

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