A Pitfall in Assessing Gastric Lymphoma after Eradication of<i>Helicobacter pylori</i>

Fischbach, Wolfgang; Engemann, R.; Stolte, Manfred

doi:10.1056/nejm199705223362115

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…These aspects clearly underline that, despite its simplicity and unexpected individual successes (48,49), H pylori eradication therapy in gastric lymphoma needs to be evaluated in clinical trials offering adequate diagnosis and close long term follow-up. Assuming that the disease is cured seems premature.…”

Section: Therapymentioning

confidence: 99%

Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy

Fischbach

1999

Canadian Journal of Gastroenterology and Hepatology

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Primary gastric lymphoma of mucosa-associated lymphoid tissue (MALT) is a distinct entity with its own histological classification. Epidemiological, histomorphological, molecular biological and experimental data clearly underline that infection of the gastric mucosa by Helicobacter pylori plays an important role in both the development and progression of MALT lymphoma. Considering the histological grade of malignancy and dissemination (stage) of the disease as decisive prognostic factors, and therapeutic determinants, endoscopic bioptical diagnosis and endoscopic ultrasound are of particular importance. In cases of localized (stage 1), low grade lymphoma, eradication of H pylori offers a promising and fascinating therapeutic option. Surgical resection, radiotherapy or chemotherapy, and their combination, have proven to be effective treatment modalities. There is a need to clarify whether operative or conservative therapeutic strategies should be favoured in the future.

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Section: Therapymentioning

confidence: 99%

Primary Gastric Lymphoma of MALT: Considerations of Pathogenesis, Diagnosis and Therapy

Fischbach

1999

Canadian Journal of Gastroenterology and Hepatology

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“…They occur with and without H. pylori reinfection. These aspects clearly Fischbach underline that despite its simplicity and unexpected individual successes [34,35], H. pylori eradication therapy in gastric MALT lymphoma should only be done in clinical trials offering an adequate diagnosis and a close, long-term follow-up. Many investigators favored primary resection of gastric lymphoma for diagnostic and therapeutic reasons and keep on doing so.…”

Section: Therapymentioning

confidence: 99%

Clinical Management of Primary Gastric Lymphoma

Fischbach¹

1999

Oncol Res Treat

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Primary gastric lymphomas of MALT (mucosa-associated lymphoid tissue) represent a distinct entity, which is documented by its own histological classification. Our knowledge about all aspects of these lymphoma has increased substantially over the last years. Epidemiological, histomorphological, molecular biological and experimental data clearly underline that Helicobacter pylori infection of the gastric mucosa without doubt plays an important role in both the development and progression of MALT lymphomas. Considering histological malignancy (low- and high-grade lymphomas) and dissemination of the disease (stage) as decisive prognostic factors and therapeutical determinants, endoscopic bioptical diagnosis as well as endoscopic ultrasound are of major importance in establishing diagnosis and clinical stage. In case of localized low-grade lymphoma, eradication of Helicobacter pylori offers a promising therapeutic option. Surgical resection and radiochemotherapy have proven to be effective treatment modalities. There is a need for randomized trials to clarify whether operative or conservative therapeutic strategies have to be favored in the future.

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