A pilot study of the effect of phospholipid curcumin on serum metabolomic profile in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial

The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: A systematic review and dose–response meta‐analysis of randomized controlled trials

“…In the overall pooled estimate of eight trials (Chashmniam et al, ; Cicero et al, ; Jazayeri‐Tehrani et al, ; Mirhafez et al, ; Navekar et al, ; Panahi et al, ; Rahmani et al, ; Saadati et al, ) with 520 participants (a dose ranging from 70 to 3,000 mg/day), it was shown that curcumin supplementation was associated with a significant reduction in BMI (WMD = −0.34 kg/m 2 , 95% CI [−0.64, −0.04], p < .05) compared with the control group (Figure ). The heterogeneity among trials investigating the effect of curcumin supplementation on BMI was high ( I 2 = 63.2%, p < .01).…”

“…Sex studies including a total of 353 participants (curcumin group = 181 and control group = 172) reported body weight as an outcome measure (Chashmniam et al, ; Jazayeri‐Tehrani et al, ; Mirhafez et al, ; Navekar et al, ; Rahmani et al, ; Saadati et al, ). Combined results from the random‐effects model showed that curcumin supplementation had no significant effect on body weight (WMD = −0.60 kg, 95% CI [−2.07, 0.87], p = .423) with significant heterogeneity among the studies ( I 2 = 81.8%, p < .001; Figure ).…”

“…Seven of the included studies described the appropriate method of randomization and blinding (Chashmniam et al, 2019;Jazayeri-Tehrani et al, 2019;Mirhafez et al, 2019;Navekar et al, 2017;Panahi et al, 2017;Rahmani et al, 2016;Saadati et al, 2019). Seven of the included trials reported adequate details of dropouts, ranging from two to 15 (Chashmniam et al, 2019;Jazayeri-Tehrani et al, 2019;Mirhafez et al, 2019;Navekar et al, 2017;Panahi et al, 2017;Rahmani et al, 2016;Saadati et al, 2019). Seven of the trials were conducted in Iran (Chashmniam et al, 2019;Jazayeri-Tehrani et al, 2019;Mirhafez et al, 2019;Navekar et al, 2017;Panahi et al, 2017;Rahmani et al, 2016;Saadati et al, 2019) and one in Italy (Cicero et al, 2019).…”

“…Seven of the included trials reported adequate details of dropouts, ranging from two to 15 (Chashmniam et al, 2019;Jazayeri-Tehrani et al, 2019;Mirhafez et al, 2019;Navekar et al, 2017;Panahi et al, 2017;Rahmani et al, 2016;Saadati et al, 2019). Seven of the trials were conducted in Iran (Chashmniam et al, 2019;Jazayeri-Tehrani et al, 2019;Mirhafez et al, 2019;Navekar et al, 2017;Panahi et al, 2017;Rahmani et al, 2016;Saadati et al, 2019) and one in Italy (Cicero et al, 2019). All studies included both women and men.…”

“…Some clinical trials reported a significant effect of curcumin consumption on indicators of body composition (Cicero et al, 2019;Jazayeri-Tehrani et al, 2019;Navekar et al, 2017;Panahi et al, 2017;Rahmani et al, 2016), whereas others reported no significant effect of curcumin intake on body mass index (BMI), body weight, or waist circumference (WC) in patients with NAFLD (Chashmniam et al, 2019;Saadati et al, 2019). A previous meta-analysis (Mousavi, Milajerdi, Varkaneh, Gorjipour, & Esmaillzadeh, 2018) found a significant effect of curcumin supplementation on BMI and body weight; however, recently published articles were not included, and five randomized controlled trials (Chashmniam et al, 2019;Cicero et al, 2019;Jazayeri-Tehrani et al, 2019;Navekar et al, 2017;Saadati et al, 2019) were missed in the abovementioned meta-analysis. Moreover, the relationship between curcumin supplementation and body composition was not investigated in a dosedependent manner in patients with NAFLD.…”