Efficacy of curcumin plus piperine co‐supplementation in moderate‐to‐high hepatic steatosis: A <scp>double‐blind,</scp> randomized, <scp>placebo‐controlled</scp> clinical trial

Sharifi, Shima; Bagherniya, Mohammad; Khoram, Ziba; Varzaneh, Amrollah Ebrahimi; Atkin, Stephen L.; Jamialahmadi, Tannaz; Sahebkar, Amirhossein; Askari, Gholamreza

doi:10.1002/ptr.7764

Cited by 9 publications

(2 citation statements)

References 67 publications

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“…Among them, liver protection is the most famous treatment effect. Sharifi et al [ 13 ] reported a double-blind, placebo-control, single-center trial. The results showed that non-alcoholic fatty liver disease (NAFLD) patients with moderate-to-high hepatic steatosis oral CUR had significantly reduced blood concentrations of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST), and alanine aminotransferase (ALT).…”

Section: Introductionmentioning

confidence: 99%

Improving the Dissolution Rate and Bioavailability of Curcumin via Co-Crystallization

Wang,

Zheng,

Tian

et al. 2024

Pharmaceuticals

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Curcumin (CUR) is a natural polyphenolic compound with various pharmacological activities. Low water solubility and bioavailability limit its clinical application. In this work, to improve the bioavailability of CUR, we prepared a new co-crystal of curcumin and L-carnitine (CUR-L-CN) via liquid-assisted grinding. Both CUR and L-CN have high safe dosages and have a wide range of applications in liver protection and animal nutrition. The co-crystal was fully characterized and the crystal structure was disclosed. Dissolution experiments were conducted in simulated gastric fluids (SGF) and simulated intestinal fluids (SIF). CUR-L-CN exhibited significantly faster dissolution rates than those of pure CUR. Hirshfeld surface analysis and wettability testing indicate that CUR-L-CN has a higher affinity for water and thus exhibits faster dissolution rates. Pharmacokinetic studies were performed in rats and the results showed that compared to pure CUR, CUR-L-CN exhibited 6.3-times-higher AUC0–t and 10.7-times-higher Cmax.

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Section: Introductionmentioning

confidence: 99%

Improving the Dissolution Rate and Bioavailability of Curcumin via Co-Crystallization

Wang,

Zheng,

Tian

et al. 2024

Pharmaceuticals

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“…In addition, the anti‐diabetic and anti‐lipidemic effects of this polyphenol have previously been confirmed (Ganji et al, 2021; Mahdavi et al, 2020; Mahdavi, Bagherniya, et al, 2021; Mahdavi, Moradi, et al, 2021; Parsamanesh et al, 2018; Rafiee et al, 2021; Talebi et al, 2020). This phytochemical also has healing effects in many liver‐related diseases, including non‐alcoholic fatty liver disease (NAFLD), hepatic steatosis, and liver fibrosis (Bagherniya et al, 2018; Dadkhah Tehrani et al, 2023; Farzaei et al, 2018; Feng et al, 2019; Hassanizadeh et al, 2023; Heidari et al, 2023; Jalali et al, 2020; Lee et al, 2019; Sharifi et al, 2023; Wu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The effect of medicinal plants on cirrhosis: A systematic review of clinical trials

Amini

Bagherniya

Butler

et al. 2023

Phytotherapy Research

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Medicinal plants with minimal side effects, low cost, and liver-protective effects can be a suitable treatment option for cirrhosis. Therefore, this systematic review aimed to determine the effectiveness of herbal medicines on cirrhosis, a life-threatening liver disease. PubMed, Scopus, Web of Science, and Google Scholar were systematically searched for clinical trials that investigated the effect of medicinal plants on cirrhosis. This review includes 11 clinical trials, of which eight studies including 613 patients assessed the effect of silymarin on cirrhosis. Three of six studies showed the beneficial effects of silymarin on aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Two studies including 118 patients investigated the effect of curcumin on cirrhosis, one showing improvement in quality of life and the other showing improvements in alkaline phosphatase (ALP), bilirubin, prothrombin time (PT), and the international normalized ratio (INR). An article including four patients investigated the effect of ginseng on cirrhosis; two patients reported improvement in the Child-Pugh score, and ascites decreased in two. All studies included here reported no or negligible side effects. Results showed that medicinal plants including silymarin, curcumin, and ginseng have beneficial effects on cirrhosis.However, due to the limited number of studies, further high-quality studies are warranted.

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Does curcumin improve liver enzymes levels in nonalcoholic fatty liver disease? A systematic review, meta‐analysis, and meta‐regression

Aragón‐Vela,

Sánchez‐Oliver,

Huertas

et al. 2024

Phytotherapy Research

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The aim of this meta‐analysis is to investigate the sources of heterogeneity in randomized clinical trials examining the effects of curcumin supplementation on liver aminotransferases in subjects with nonalcoholic fatty liver disease (NAFLD). We conducted a systematic search of the PubMed, SCOPUS, and Web of Science databases for randomized clinical trials and identified 15 studies (n = 835 subjects). We used random‐effects models with DerSimonian‐Laird methods to analyze the serum levels of alanine aminotransferase and aspartate aminotransferase enzymes. Our results indicate that curcumin did not affect serum alanine aminotransferase, but it did reduce aspartate aminotransferase levels. Notably, both outcomes showed high heterogeneity (p < 0.01). Subgroup analysis revealed that adding piperine to curcumin did not benefit aminotransferase levels in NAFLD patients. Additionally, we found a negative correlation between the duration of the intervention and the relative (mg/kg/day) curcumin dose with the reduction in liver aminotransferases. In summary, the sources of heterogeneity identified in our study are likely attributed to the duration of the intervention and the relative dose of curcumin. Consequently, longer trials utilizing high doses of curcumin could diminish the positive impact of curcumin in reducing serum levels of aminotransferases in patients with NAFLD.

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Efficacy of curcumin plus piperine co‐supplementation in moderate‐to‐high hepatic steatosis: A double‐blind, randomized, placebo‐controlled clinical trial

Cited by 9 publications

References 67 publications

Improving the Dissolution Rate and Bioavailability of Curcumin via Co-Crystallization

Improving the Dissolution Rate and Bioavailability of Curcumin via Co-Crystallization

The effect of medicinal plants on cirrhosis: A systematic review of clinical trials

Does curcumin improve liver enzymes levels in nonalcoholic fatty liver disease? A systematic review, meta‐analysis, and meta‐regression

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