A pilot study of the effect of granulocyte–macrophage colony–stimulating factor on oral mucositis in head and neck cancer patients during x-radiation therapy: a preliminary report

Nicolatou, O; Sotiropoulou-Lontou, Anastasia; Skarlatos, John; Kyprianou, Konstantinos; Kolitsi, Georgia; Dardoufas, K.

doi:10.1016/s0360-3016(98)00253-3

Cited by 52 publications

(25 citation statements)

References 18 publications

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“…However, the panel decided that a guideline against the use of GM-CSF mouthrinses in all patients treated with various stomatotoxic CT regimens was not possible, since only one site-specific and highly mucotoxic CT regimen was evaluated in this study. Nicolatou-Galitis et al [57,58] reported results from a case series suggesting a preventative effect of GM-CSF mouthwashes on mucositis in patients receiving RT for H&N cancer, whereas controlled studies by Saarilahti et al and Mantovani et al [59,60] reported only a marginal effect. In contrast, Sprinzl et al [61] found no benefit ( Table 1).…”

Section: Granulocyte Colony-stimulating Factormentioning

confidence: 99%

Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients

Raber-Durlacher

Bültzingslöwen²,

Logan

et al. 2012

Support Care Cancer

112

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Purpose The aim of this project was to review the literature and define clinical practice guidelines for the use of cytokines and growth factor agents for the prevention or treatment of oral mucositis induced by cancer chemotherapy or radiotherapy. Care Cancer (2013) 21:343-355 DOI 10.1007/s00520-012-1594 following three guideline determinations was possible: Recommendation, Suggestion, No guideline possible. Results Sixty-four clinical studies across 11 interventions were evaluated. A recommendation was made for the use of recombinant human KGF-1 (palifermin) at a dose of 60 μg/kg per day for 3 days prior to conditioning treatment and for 3 days post-transplant for prevention of oral mucositis in patients receiving high-dose chemotherapy and total body irradiation followed by autologous stem cell transplantation for hematological malignancies. A suggestion was made against using granulocyte macrophage colony-stimulating factor mouthwash for the prevention of oral mucositis in the setting of high-dose chemotherapy followed by autologous or allogeneic stem cell transplantation. No guideline was possible for any other cytokine or growth factor agents due to inconclusive evidence. Conclusions Of the cytokine and growth factor agents studied for oral mucositis, the evidence only supports use of palifermin in the specific population listed above. Additional welldesigned research is needed on other cytokine and growth factor interventions and in other cancer treatment settings. Methods

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Section: Granulocyte Colony-stimulating Factormentioning

confidence: 99%

Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients

Raber-Durlacher

Bültzingslöwen²,

Logan

et al. 2012

Support Care Cancer

112

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“…It is scored in four grades; mucositis grade 1 is characterized by a diffuse erythema, mucositis grade 2 refers to the development of small foci of ulcers, whereas mucositis grades 3 and 4 are characterized by painful ulcerations extending on more than half of the oral mucosa [3,13,22].…”

Section: Introductionmentioning

confidence: 99%

Effect of fluconazole antifungal prophylaxis on oral mucositis in head and neck cancer patients receiving radiotherapy

Nicolatou‐Galitis

Velegraki

Sotiropoulou-Lontou

et al. 2005

Support Care Cancer

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“…Although no effective treatment for OM has yet been found, several studies have demonstrated that subcutaneous administration of colony-stimulating factors (G-CSF or GM-CSF) can improve OM. Furthermore, topical administration of GM-CSF improves OM in patients receiving chemo/radiotherapy for head and neck cancer 14,15 and breast cancer. 16 In order to assess the effect of topical rhGM-CSF on OM secondary to high-dose chemo/radiotherapy in hematological patients, we conducted a prospective randomized double-blind trial including 41 consecutive patients.…”

Section: Discussionmentioning

confidence: 99%

Mouth-washings with recombinant human granulocyte–macrophage colony stimulating factor (rhGM-CSF) do not improve grade III–IV oropharyngeal mucositis (OM) in patients with hematological malignancies undergoing stem cell transplantation. Results of a randomized double-blind placebo-controlled study

Valcárcel

Sanz

Sureda

et al. 2002

Bone Marrow Transplant

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Summary:We investigated whether daily oral washings with recombinant human granulocyte-macrophage colonystimulating factor (rhGM-CSF) solution improved grade III-IV oropharyngeal mucositis (OM) in patients with hematological malignancies undergoing stem cell transplantation. Forty-one consecutive patients (21 males and 20 females, median age (range) 44 (16-69) years) were prospectively randomized to perform daily mouth-washes with either a 400 g rhGM-CSF (Molgramostin, Schering-Plough) solution (group A, n ‫؍‬ 18) or with a saline solution (group B, n ‫؍‬ 23). Primary end-points were the intensity of OM, night rest quality and characteristics of food intake. Secondary end-points were need for and duration of parenteral nutrition, oral and intravenous analgesic requirements, incidence of viral or fungal oral infections and development of neutropenic fever. No differences were found between the placebo and rhGM-CSF-treated groups regarding overall duration of OM, maximum grade, reduction in at least one grade of OM (nine patients (56%) in group A vs 13 patients (68%) in group B), reduction of spontaneous or swallowing-induced pain, improvement in oral food intake, use of parenteral nutrition or use of systemic analgesics. In conclusion, mouth-washings with a 400 g of rhGM-CSF solution do not improve severe OM in hematological patients undergoing stem cell transplantation.

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A pilot study of the effect of granulocyte–macrophage colony–stimulating factor on oral mucositis in head and neck cancer patients during x-radiation therapy: a preliminary report

Cited by 52 publications

References 18 publications

Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients

Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients

Effect of fluconazole antifungal prophylaxis on oral mucositis in head and neck cancer patients receiving radiotherapy

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