A Pilot Study of the Efficacy of Heart Rate Variability (HRV) Biofeedback in Patients with Fibromyalgia

Hassett, Afton L.; Radvanski, Diane C.; Vaschillo, Evgeny; Vaschillo, Bronya; Sigal, Leonard H.; Karavidas, Maria Katsamanis; Buyske, Steven; Lehrer, Paul M.

doi:10.1007/s10484-006-9028-0

Cited by 230 publications

(179 citation statements)

References 59 publications

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“…The observed improvement in anxiety is consistent with many reports of reduced heart rate variability in anxiety disorders (39,40) and the ability of PYD to improve heart rate variability (28,41). There is some preliminary evidence that increasing heart rate variability through biofeedback benefits some clinical features of FM (42).…”

Section: Discussionsupporting

confidence: 88%

A six‐month randomized controlled trial of exercise and pyridostigmine in the treatment of fibromyalgia

Jones¹,

Burckhardt²,

Deodhar³

et al. 2008

Arthritis & Rheumatism

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Objective. A subset of fibromyalgia (FM) patients have a dysfunctional hypothalamic-pituitary-insulinlike growth factor 1 (IGF-1) axis, as evidenced by low serum levels of IGF-1 and a reduced growth hormone (GH) response to physiologic stimuli. There is evidence that pyridostigmine (PYD) improves the acute response of GH to exercise in FM patients. The purpose of this study was to evaluate the clinical effectiveness of 6 months of PYD and group exercise on FM symptoms.Methods. FM patients were randomized to 1 of the following 4 groups: PYD plus exercise, PYD plus diet recall but no exercise, placebo plus exercise, and placebo plus diet recall but no exercise. The primary outcome measures were the visual analog scale (VAS) score for pain, tender point count, and total myalgic score. Secondary outcome measures were the total score on the Fibromyalgia Impact Questionnaire (FIQ) and FIQ VAS scores for individual symptoms (fatigue, poor sleep, stiffness, and anxiety), as well as quality of life (QOL) and physical fitness (lower body strength/ endurance, upper and lower body flexibility, balance, and time on the treadmill).Results. A total of 165 FM patients completed baseline measurements; 154 (93.3%) completed the study. The combination of PYD and exercise did not improve pain scores. PYD groups showed a significant improvement in sleep and anxiety in those who completed the study and in QOL in those who complied with the therapeutic regimen as compared with the placebo groups. Compared with the nonexercise groups, the 2 exercise groups demonstrated improvement in fatigue and fitness. PYD was generally well tolerated.Conclusion. Neither the combination of PYD plus supervised exercise nor either treatment alone yielded improvement in most FM symptoms. However, PYD did improve anxiety and sleep, and exercise improved fatigue and fitness. We speculate that PYD may have improved vagal tone, thus benefiting sleep and anxiety; this notion warrants further study.

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Section: Discussionsupporting

confidence: 88%

A six‐month randomized controlled trial of exercise and pyridostigmine in the treatment of fibromyalgia

Jones¹,

Burckhardt²,

Deodhar³

et al. 2008

Arthritis & Rheumatism

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“…However, this was only partly supported by an improvement in bodily pain assessed with SF-36, whereas no treatment effect was revealed from pain assessed with Borg CR-10 scale. It is well known that HRV BF acutely affects ANS regulation (Hassett et al 2007;Wheat and Larking 2010). It was, thus, expected that improvement in symp-toms would be related to an increase in HRV.…”

Section: Subjective Ratingsmentioning

confidence: 99%

Effects of Heart Rate Variability Biofeedback in Subjects with Stress-Related Chronic Neck Pain: A Pilot Study

Hallman

Olsson

Schéele

et al. 2011

Appl Psychophysiol Biofeedback

120

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Recent studies focusing on autonomic nervous system (ANS) dysfunctions, together with theoretical pathophysiological models of musculoskeletal disorders, indicate the involvement of ANS regulation in development and maintenance of chronic muscle pain. Research has demonstrated the effectiveness of heart rate variability (HRV) biofeedback (BF) in increasing HRV and reducing the symptoms of different disorders characterized by ANS aberration. The study investigated the effects of resonance frequency HRV BF on autonomic regulation and perceived health, pain, stress and disability in 24 subjects with stress-related chronic neckshoulder pain. Twelve subjects participated in 10 weekly sessions of resonant HRV BF and were compared to a control group. Subjective reports and HRV measures during relaxation and in response to a standardized stress protocol were assessed for both groups pre-and postintervention. Group X time interactions revealed a significantly stronger increase over time in perceived health (SF-36) for the treatment group, including vitality, bodily pain and social functioning. Interactions were also seen for HRV during relaxation and reactivity to stress.The present pilot study indicates improvement in perceived health over a 10 week intervention with HRV-biofeedback in subjects with chronic neck-pain. Increased resting HRV as well as enhanced reactivity to hand grip and cold pressor tests might reflect beneficial effects on ANS regulation, and suggest that this intervention protocol is suitable for a larger controlled trial.

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“…This phenomenon is used for baroreflex stimulation in deep breathing with a frequency of 0.1 Hz [3]. Such stimulation of the baroreflex is applied in the clinical practice for treating various diseases related to physical and mental disorders [4][5][6][7], as well as for assessing the functioning of the baroreflectory mechanism [8] and the physical and mental status of patients [9].…”

Section: Introductionmentioning

confidence: 99%

Роль Гидродинамических Параметров В Формировании Низкочастотных Колебаний Артериального Давления У Человека

Grinevich¹

2016

Math.Biol.Bioinf.

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Abstract. The mechanism of forming of low-frequency oscillations in the human cardiovascular system is a burning issue today. The current paper considers a hypothesis of hydrodynamic nature of these oscillations, which are formed without the involvement of autonomous control of the cardiovascular system from the autonomic nervous system. The developed reduced hydrodynamic model was used to study the system response on additive periodic perturbation of wide-ranged frequencies that affects the performance of the heart pump, as well as the role of hydrodynamic parameters of the cardiovascular bed in this process. It was shown that low-frequency perturbation of pump wall rigidity forms low-frequency oscillations in the arterial part of the cardiovascular flow without autonomous control, with the maximum amplitude observed at frequency close to 0.1 Hz.

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A Pilot Study of the Efficacy of Heart Rate Variability (HRV) Biofeedback in Patients with Fibromyalgia

Cited by 230 publications

References 59 publications

A six‐month randomized controlled trial of exercise and pyridostigmine in the treatment of fibromyalgia

A six‐month randomized controlled trial of exercise and pyridostigmine in the treatment of fibromyalgia

Effects of Heart Rate Variability Biofeedback in Subjects with Stress-Related Chronic Neck Pain: A Pilot Study

Роль Гидродинамических Параметров В Формировании Низкочастотных Колебаний Артериального Давления У Человека

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