A Pilot Study Of Pharmacotherapy (Naltrexone) For Hazardous Drinking Among Women Infected With HIV

Abstract

obtained from 1225 patients [709 male, 516 female]. The average age of the patients was found to be 56.8±0.5 years. The average number of medications prescribed was 10.6±0.2. 585 patients were found to be aged 60 years or more and 613 patients were in the age group 18-60 years. Out of the 1225 patients, 848 did not have any medication error. An error was noted on only in 377 patient profiles. The total number of medication errors was found to be 638. Of these, 597 were errors 'with no harm' and only 41 were errors 'with harm'. Of these medication errors, drug interactions (DIs) were found to be leading the list with 50% of the medication errors. Cardiovascular agents contributed maximum to the DIs followed by anticoagulants and antimicrobial agents. Only 172 DIs had a moderate severity. DIs was followed by duplication of therapy (20%), incorrect interval (10%), monitoring error, incompleteness of prescription, omission error and overdosing, respectively. CONCLUSIONS: These results confirm that drug interaction continue to lead the list of medication errors in Indian tertiary health care settings. The study is ongoing to determine the interventions to reduce the errors.

Effectiveness of naltrexone treatment for alcohol use disorders in HIV: a systematic review

“…As shown in Table 1, two of these studies have used oral naltrexone (NTX) [44,49] and the 5 other used extendedrelease injectable form (XR-NTX) [45][46][47][48]50]. The difference between reported outcomes and a small number of studies has made it difficult to present results in a metaanalysis.…”

“…Although these changes were significant for each group alone, there was no significant difference between the two treatment groups. Hu et al, 2013 investigated the effectiveness of using NTX in reducing heavy alcohol use on 19 women infected with HIV from 2010 to 2012[49]. They were randomized 2:1 and received 50 mg NTX orally or placebo for 7-months.…”