A Pilot Study of Normative Data for Macular Thickness and Volume Measurements Using Cirrus High-Definition Optical Coherence Tomography

Liu, Tiffany; Hu, Allen; Kaines, Andrew; Yu, Fei; Schwartz, Steven D.; Hubschman, Jean‐Pierre

doi:10.1097/iae.0b013e31820d3f13

Cited by 38 publications

(27 citation statements)

References 25 publications

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“…[29][30][31][32] Further supporting evidence for this is found in other OCT studies providing normative adult data. [33][34][35] In these studies, the SDs reported for CMT were 14.5 lm, 35 22.5 lm, 33 and 16.81 lm. 34 This is consistent with the SD of 13.83 lm calculated for CMT in our adult group.…”

Section: Discussionmentioning

confidence: 84%

In Vivo Foveal Development Using Optical Coherence Tomography

Lee

Purohit

Patel

et al. 2015

Invest. Ophthalmol. Vis. Sci.

109

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PURPOSE.To characterize the time course of normal foveal development in vivo in term infants and young children using handheld spectral-domain optical coherence tomography (HH-SDOCT). METHODS.We obtained 534 HH-SDOCT scans from 261 infants, children, and young adults with a mean age of 4.9 years (range, 0-27 years). Each retinal layer was manually segmented in ImageJ and correlated with gestational age (GA) and visual acuity (VA). The developmental trajectories of each retinal layer at the fovea, parafovea, and perifovea were calculated using fractional polynomial modeling.RESULTS. The central macular thickness (CMT) increases logarithmically between birth and 48.6 months GA. The foveal ganglion cell (GCL), inner plexiform, inner nuclear (INL), and outer plexiform layers decrease in thickness exponentially until 18 months GA. Interestingly, the parafoveal and perifoveal GCL and INL thicknesses initially decrease until 17 months GA and then increase in thickness until 65.5 GA. The foveal outer nuclear layer, inner segment, and outer segment of the photoreceptors increase in thickness logarithmically until 32.4, 26.9, and 45.3 months GA, respectively. The parafoveal and perifoveal outer retinal layers increase in thickness more gradually until 146 months GA. The thickness of the outer retinal layers and CMT were strongly correlated with VA, with r ¼ 0.54 (P < 0.0001) and r ¼ 0.52 (P < 0.0001), respectively. CONCLUSIONS.We have modeled for the first time the complex, nonlinear developmental trajectories for each retinal layer and demonstrate that development continues until adolescence. Our description of normal development will be helpful in diagnosing, monitoring, and understanding pediatric retinal disease.

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Section: Discussionmentioning

confidence: 84%

In Vivo Foveal Development Using Optical Coherence Tomography

Lee

Purohit

Patel

et al. 2015

Invest. Ophthalmol. Vis. Sci.

109

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“…This has been proposed as a more objective method of reporting clinically important CME that minimizes interpatient and interinstitution variability, and it automatically adjusts for the normal variation (as much as 100 mm) in retinal thickness that exists among healthy eyes. 31,39 Moreover, this latter definition does not rely on cystoid changes, which require interpretation and which may not be clinically important if mild or present outside the fovea (Fig 1). As with all literature reviews, the findings of this assessment should be interpreted with caution and may not be generalizable to patients possessing characteristics different from patients enrolled in the studies reviewed.…”

Section: Discussionmentioning

confidence: 98%

Topical Nonsteroidal Anti-inflammatory Drugs and Cataract Surgery

Schoenberger²,

et al. 2015

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Cystoid macular edema after cataract surgery has a tendency to resolve spontaneously. There is a lack of level I evidence that supports the long-term benefit of NSAID therapy to prevent vision loss from CME at 3 months or more after cataract surgery. Although dosing of NSAIDs before surgery may hasten the speed of visual recovery in the first several weeks after cataract surgery, there is no evidence that this practice affects long-term visual outcomes. Standardized reporting of CME based on OCT may allow for more uniform quantitation of its incidence and more reliable assessment of treatment outcomes.

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“…The quantification of macular thickness by SD-OCT is now a reproducible and noninvasive technique 21 that enables clinicians to monitor the efficacy of treatment for macular pathologies such as diabetic or venous macular edema. Previous studies with SD-OCT 21,22 and swept-source OCT have provided sex-and age-related central macular thickness data in normal subjects.…”

Section: Resultsmentioning

confidence: 99%