A pilot randomized placebo controlled trial of 2 Aloe vera supplements in patients with pre-diabetes/metabolic syndrome

Devaraj, Sridevi; Jialal, Rohan; Jialal, I.; Rockwood, Jason

doi:10.1055/s-0028-1083957

Cited by 15 publications

(7 citation statements)

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“… 43 In a randomized controlled trial, A. vera gel complex reduced body weight, body fat mass, and insulin resistance in obese prediabetes and early nontreated diabetic patients. 45 Further, in a pilot study, two Aloe products in patients with prediabetes over an 8-week period, tended to revert the impaired fasting glucose and impaired glucose tolerance observed in conditions of prediabetes/metabolic syndrome. 45 One study discussed the efficacy of aloe-emodin-8- O -glycoside isolated from A. vera gel in enhancing glucose transport by modulating the proximal and distal markers involved in glucose uptake and its transformation into glycogen.…”

Section: Clinical Efficacy and Mechanism Of Actionmentioning

confidence: 89%

“… 45 Further, in a pilot study, two Aloe products in patients with prediabetes over an 8-week period, tended to revert the impaired fasting glucose and impaired glucose tolerance observed in conditions of prediabetes/metabolic syndrome. 45 One study discussed the efficacy of aloe-emodin-8- O -glycoside isolated from A. vera gel in enhancing glucose transport by modulating the proximal and distal markers involved in glucose uptake and its transformation into glycogen. 46 Tanaka et al reported reductions in both fasting and random blood glucose levels of db/db diabetic mice chronically treated with the same phytosterols from A. vera gel.…”

Section: Clinical Efficacy and Mechanism Of Actionmentioning

confidence: 89%

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Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review

Radha

Nampoothiri

2015

Journal of Traditional and Complementary Medicine

393

297

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Aloe vera (蘆薈 lú huì) is well known for its considerable medicinal properties. This plant is one of the richest natural sources of health for human beings coming. The chemistry of the plant has revealed the presence of more than 200 different biologically active substances. Many biological properties associated with Aloe species are contributed by inner gel of the leaves. Most research has been centralized on the biological activities of the various species of Aloe, which include antibacterial and antimicrobial activities of the nonvolatile constituents of the leaf gel. Aloe species are widely distributed in the African and the eastern European continents, and are spread almost throughout the world. The genus Aloe has more than 400 species but few, such as A. vera, Aloe ferox, and Aloe arborescens, are globally used for trade. A. vera has various medicinal properties such as antitumor, antiarthritic, antirheumatoid, anticancer, and antidiabetic properties. In addition, A. vera has also been promoted for constipation, gastrointestinal disorders, and for immune system deficiencies. However, not much convincing information is available on properties of the gel. The present review focuses on the detailed composition of Aloe gel, its various phytocomponents having various biological properties that help to improve health and prevent disease conditions.

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Section: Clinical Efficacy and Mechanism Of Actionmentioning

confidence: 89%

Section: Clinical Efficacy and Mechanism Of Actionmentioning

confidence: 89%

Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review

Radha

Nampoothiri

2015

Journal of Traditional and Complementary Medicine

393

297

View full text Add to dashboard Cite

show abstract

“…Postprandial hyperglycemia is characterized by a rapid increase in blood glucose levels in diabetic patients. An investigation confirmed that A. vera decreased diabetes severity by lowering blood glucose levels in type 2 diabetic patients [ 322 ]. Other clinical studies have suggested that A. vera gel may act as a safe antihyperglycemic and antihypercholesterolemic agent in type 2 diabetic patients, without any significant effects on other normal blood lipid levels or liver/kidney function [ 323 ].…”

Section: Clinical Efficacy Of Aloe Plants In Humentioning

confidence: 90%

“…In a randomized controlled trial, A. vera gel complex reduced body weight, body fat mass, and insulin resistance in obese pre-diabetic and early non-treated diabetic patients [ 322 ]. Further, in a pilot study, two Aloe products in pre-diabetic patients over an eight-week period, tended to revert impaired fasting glucose levels and impaired glucose tolerance observed in pre-diabetes/metabolic syndrome conditions [ 322 ].…”

Section: Clinical Efficacy Of Aloe Plants In Humentioning

confidence: 99%

Aloe Genus Plants: From Farm to Food Applications and Phytopharmacotherapy

Salehi

Albayrak

Antolak

et al. 2018

IJMS

147

101

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Aloe genus plants, distributed in Old World, are widely known and have been used for centuries as topical and oral therapeutic agents due to their health, beauty, medicinal, and skin care properties. Among the well-investigated Aloe species are A. arborescens, A. barbadensis, A. ferox, and A. vera. Today, they account among the most economically important medicinal plants and are commonly used in primary health treatment, where they play a pivotal role in the treatment of various types of diseases via the modulation of biochemical and molecular pathways, besides being a rich source of valuable phytochemicals. In the present review, we summarized the recent advances in botany, phytochemical composition, ethnobotanical uses, food preservation, and the preclinical and clinical efficacy of Aloe plants. These data will be helpful to provide future directions for the industrial and medicinal use of Aloe plants.

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“…Aloe gel complex also lowered the body weight in obese prediabetic and early onset diabetic individuals in a randomized controlled experiment. Furthermore, two Aloe products seems to improve the impaired glucose tolerance found in prediabetic syndrome individuals in an 8-week pilot study [88].…”

Section: Anti-diabetic Activitymentioning

confidence: 98%

A Review on Pharmacological and Therapeutic Potential of Aloe barbadensis Miller

Sharma

Purohit

Chaubey

et al. 2022

EJMP

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Aloe vera, a popular succulent perennial medicinal plant with a wide range of phytochemicals that have shown various pharmacological activities including anti-oxidant, antimicrobial, antidiabetic, wound healing promotion and so on. Acemannan, aloe-emodin, aloin, aloesin, and emodin are widely investigated active constituents that show various pharmacological activities. Thus, the purpose of this review is to highlight previous pharmacological studied conducted in vivo, in vitro and human assays over the past decades. As current pharmacological research is focused on anticancer and neurological action, it would be interesting and important to study the main compounds present in Aloe vera for therapeutic purposes.

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A pilot randomized placebo controlled trial of 2 Aloe vera supplements in patients with pre-diabetes/metabolic syndrome

Cited by 15 publications

References 0 publications

Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review

Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review

Aloe Genus Plants: From Farm to Food Applications and Phytopharmacotherapy

A Review on Pharmacological and Therapeutic Potential of Aloe barbadensis Miller

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