A pilot randomized controlled trial evaluating an integrated treatment of rivastigmine transdermal patch and cognitive stimulation in patients with Alzheimer's disease

Sancarlo, Daniele; Addante, Filomena; Ciccone, Filomena; Cascavilla, Leandro; Paris, Francesco; Elia, Anna Chiara; Nuzzaci, Claudia; Picoco, Michele; Greco, Antonio

doi:10.1002/gps.4247

Cited by 40 publications

(29 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies included elderly at risk for dementia [67], elderly with mild cognitive impairments [63,70], patients with mild to moderate dementia [64,66], moderate to severe dementia [69], diagnosed with Alzheimer disease [61,62,64,65,68], or a combination of these patients [59,60]. Assessment of cognitive impairment was mostly conducted with the MMSE, but also with other measurements (ADAS-Cog, Clinical Dementia Ranking -CDR).…”

Section: Mixed Trialsmentioning

confidence: 99%

“…For example, Quintana-Hernández et al [68] conducted treatment for 2 years, with 3-weekly sessions (90 min per session), while Buettner et al [60] only conducted treatment for 4 weeks, two times a week (60 min per session). Control conditions varied also between studies, from sham intervention [67] to usual care [68] to a rivastigmine transdermal patch as control condition [61].…”

Section: Mixed Trialsmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive Therapy for Dementia Patients: A Systematic Review

Carrión

Folkvord

Anastasiadou

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Background: Cognitive therapy is a well-established intervention for treating elderly suffering from dementia. In particular, reality orientation and skills training seem to be effective interventions for reversing cognitive impairment among elderly, although findings are inconclusive. Therefore, a systematic update of the existing evidence of cognitive therapy for people suffering from dementia is needed. Aim: To review existing scientific evidence regarding the efficacy of cognitive therapies for elderly suffering from dementia. Methods: Studies were retrieved from several bibliographic databases (January 2009 to December 2017) with prespecified selection criteria, data extraction, and methodological quality assessment. Results: In total, 10 reality orientation, 25 skills training, and 12 mixed trials were identified as meeting the inclusion criteria and were systematically reviewed. Results from reality orientation trials showed minor effects for cognitive assessments, while skills training trials and mixed trials showed contradicting effects on cognition. Effects on other outcomes (e.g., daily functioning, depression, language) were limited or not found. Conclusions: Skills training trials and mixed trials seem to affect cognitive impairment in a positive way, although the results are inconclusive. Comparison between studies was difficult due to differences in form of intervention. Because findings are inconclusive, more structuralized and comparable randomized controlled trials are needed.

show abstract

Section: Mixed Trialsmentioning

confidence: 99%

Section: Mixed Trialsmentioning

confidence: 99%

Cognitive Therapy for Dementia Patients: A Systematic Review

Carrión

Folkvord

Anastasiadou

et al. 2018

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…The cut-off score for probable depression is 6, while a score of 10 or higher is indicative of depression. The 15-item version of the GDS has been previously used to assess depression in patients with AD [28,29].…”

Section: Instrumentsmentioning

confidence: 99%

Self-Perceived Quality of Life Among Patients with Alzheimer’s Disease: Two Longitudinal Models of Analysis

Conde-Sala

Turró‐Garriga

Portellano-Ortiz

et al. 2016

JAD

View full text Add to dashboard Cite

Abstract.The objective was to analyze the factors that influence self-perceived quality of life (QoL) in patients with Alzheimer's disease (AD), contrasting two different longitudinal models. A total of 127 patients were followed up over 24 months. The instruments applied were: Quality of Life in Alzheimer's Disease scale (QoL-AD), Geriatric Depression Scale-15, Anosognosia Questionnaire-Dementia, Disability Assessment in Dementia, Neuropsychiatric Inventory, and the Mini-Mental State Examination. Two models for grouping patients were tested: 1) Baseline score on the QoL-AD (QoLBaseline), and 2) Difference in QoL-AD score between baseline and follow-up (QoL-Change). Generalized estimating equations were used to analyze longitudinal data, and multinomial regression analyses were performed. Over the follow-up period the QoL-Baseline model showed greater variability between groups (Wald χ 2 = 172.3, p < 0.001) than did the QoLChange model (Wald χ 2 = 1.7, p = 0.427). In the QoL-Baseline model the predictive factors were greater depression (odds ratio [OR] = 1.20; 95% CI: 1.00-1.45) and lower functional ability (OR = 0.92; 95% CI: 0.85-0.99) for the Low QoL group (< 33 QoL-AD), and less depression (OR = 0.68; 95% CI: 0.52-0.88), more anosognosia (OR = 1.07; 95% CI: 1.01-1.13), and fewer neuropsychiatric symptoms (OR = 0.95; 95% CI: 0.91-0.99) for the High-QoL group (>37 QoL-AD). The model based on baseline scores (QoL-Baseline) was better than the QoL-Change model in terms of identifying trajectories and predictors of QoL in AD.

show abstract

“…9 Furthermore, initial evidence suggests that the MPI can be considered as universal patient-centred end-point to assess the effects of pharmacological and non-pharmacological interventions in patients with dementia and depression. 10,11 This approach allows the quantification of the effects of therapy on the MPI score as a whole as well as on the scores of individual components of the tool.…”

Section: Multidimensional Prognostic Index In Frail Older Patientsmentioning

confidence: 99%

Using the multidimensional prognostic index for treatment decisions and monitoring in frail older patients

Mangoni

2017

Geriatr Care

View full text Add to dashboard Cite

The routine applicability of clinical guidelines and disease-specific end-points in frail older patients is problematic because of the exclusion of this group from clinical trials, their limited life expectancy, the co-existence of multiple disease states and poor functional status, and the presence of complex drug-drug and drug-disease interactions. In this context, the use of patient-centred end-points that include measures of quality of life might be particularly useful for designing tailored treatment strategies, monitor progress and, ultimately, improve outcomes. The multidimensional prognostic index, an objective, quantifiable, and validated scoring system based on core domains of the comprehensive geriatric assessment, might represent an important tool for the development of clinical guidelines that take into account measures of frailty and patientcentred end-points. However, research is warranted to investigate whether this approach leads to more effective and safe management strategies in old age.

show abstract

A pilot randomized controlled trial evaluating an integrated treatment of rivastigmine transdermal patch and cognitive stimulation in patients with Alzheimer's disease

Abstract: The integrated treatment of RTP with CS in AD patients for 6 months improved significantly cognition, depressive and neuropsychiatric symptoms, functional status, and mortality risk in comparison with a group of AD patients receiving only RTP.

Cited by 40 publications

References 70 publications

Cognitive Therapy for Dementia Patients: A Systematic Review

Cognitive Therapy for Dementia Patients: A Systematic Review

Self-Perceived Quality of Life Among Patients with Alzheimer’s Disease: Two Longitudinal Models of Analysis

Using the multidimensional prognostic index for treatment decisions and monitoring in frail older patients

Contact Info

Product

Resources

About