A pilot randomised controlled trial to reduce suffering and emotional distress in patients with advanced cancer

Lloyd‐Williams, Mari; Cobb, Mark; O’Connor, Christina; Dunn, Laurie; Shiels, Christopher

doi:10.1016/j.jad.2012.11.013

Cited by 41 publications

(35 citation statements)

References 19 publications

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“…According to Lépine (), anxiety symptoms can cause great suffering and even result in disability of individuals affected by this illness. Therefore, recently, there has been growing interest in providing interventions to alleviate emotional distress and suffering in patients with advanced cancer (Lloyd‐Williams et al , ).…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia

Pimenta

Alves

Pimenta³

et al. 2016

Phytotherapy Research

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The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10 mg), or the placebo. The evaluation was performed through psychometric scales [State-Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI-S scores, suggesting an anxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML.

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Section: Introductionmentioning

confidence: 99%

Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia

Pimenta

Alves

Pimenta³

et al. 2016

Phytotherapy Research

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“…For example, patients can become anxious or depressed when they bring life events from the past back into their memories [53,54]. We believe it is of utmost importance to assess the effects of our intervention therefore we will also measure for anxiety and depression.…”

Section: Discussionmentioning

confidence: 99%

The life in sight application study (LISA): design of a randomized controlled trial to assess the role of an assisted structured reflection on life events and ultimate life goals to improve quality of life of cancer patients

et al. 2013

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BackgroundIt is widely recognized that spiritual care plays an important role in physical and psychosocial well-being of cancer patients, but there is little evidence based research on the effects of spiritual care. We will conduct a randomized controlled trial on spiritual care using a brief structured interview scheme supported by an e-application. The aim is to examine whether an assisted reflection on life events and ultimate life goals can improve quality of life of cancer patients.Methods/DesignBased on the findings of our previous research, we have developed a brief interview model that allows spiritual counsellors to explore, explicate and discuss life events and ultimate life goals with cancer patients. To support the interview, we created an e-application for a PC or tablet. To examine whether this assisted reflection improves quality of life we will conduct a randomized trial. Patients with advanced cancer not amenable to curative treatment options will be randomized to either the intervention or the control group. The intervention group will have two consultations with a spiritual counsellor using the interview scheme supported by the e-application. The control group will receive care as usual. At baseline and one and three months after randomization all patients fill out questionnaires regarding quality of life, spiritual wellbeing, empowerment, satisfaction with life, anxiety and depression and health care consumption.DiscussionHaving insight into one’s ultimate life goals may help integrating a life event such as cancer into one’s life story. This is the first randomized controlled trial to evaluate the role of an assisted structured reflection on ultimate life goals to improve patients’ quality of life and spiritual well being. The intervention is brief and based on concepts and skills that spiritual counsellors are familiar with, it can be easily implemented in routine patient care and incorporated in guidelines on spiritual care.Trial registrationThe study is registered at ClinicalTrials.gov: NCT01830075

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“…La psychothérapie de soutien faite d'écoute active, de réassu-rance, d'empathie et de réconfort type relation d'aide peut compléter dans un premier temps l'approche pharmacologique. Une étude pilote britannique récente, effectuée chez des patients ayant un cancer en phase avancé, aurait montré l'inté-rêt d'une thérapie basée sur la narration pour diminuer les niveaux d'anxiété et de dépression [85]. Une étude a rapporté l'intérêt de la sismothérapie ou électro-convulsivothérapie chez des patients en situation palliative et ayant une dépression sévère et résistante aux traitements médi-camenteux [86].…”

Section: Traitements Médicamenteuxunclassified

Les troubles psychiatriques en soins palliatifs et en fin de vie

Reich

2015

La Presse Médicale

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A pilot randomised controlled trial to reduce suffering and emotional distress in patients with advanced cancer

Cited by 41 publications

References 19 publications

Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia

Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia

The life in sight application study (LISA): design of a randomized controlled trial to assess the role of an assisted structured reflection on life events and ultimate life goals to improve quality of life of cancer patients

Les troubles psychiatriques en soins palliatifs et en fin de vie

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