2014
DOI: 10.1186/1471-2490-14-66
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A pilot prospective study to evaluate whether the bladder morphology in cystography and/or urodynamic may help predict the response to botulinum toxin a injection in neurogenic bladder refractory to anticholinergics

Abstract: BackgroundWe have observed different clinical responses to botulinum toxin A (BTX-A) in patients who had similar urodynamic parameters before the procedure. Furthermore, some bladders evaluated by cystography and cystoscopy during the procedure had different characteristics that could influence the outcome of the treatment. The aim of this study was to assess whether cystography and urodynamic parameters could help predict which patients with neurogenic detrusor overactivity (NDO) refractory to anticholinergic… Show more

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Cited by 11 publications
(6 citation statements)
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References 18 publications
(21 reference statements)
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“…Clinicians undertaking X-ray video cystography using contrast medium during urodynamics are already aware that the bladder can vary in shape and outline. 10,15 The bladder can appear relaxed, following the normal contours of the pelvis (Figure 1) or more rounded, pear-shaped or fir-tree shaped. 11 Mathematical modelling has previously been used to try and make sense of bladder shape as it fills and empties; however, the clinical application of these methods to-date has been limited.…”
Section: Discussionmentioning
confidence: 99%
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“…Clinicians undertaking X-ray video cystography using contrast medium during urodynamics are already aware that the bladder can vary in shape and outline. 10,15 The bladder can appear relaxed, following the normal contours of the pelvis (Figure 1) or more rounded, pear-shaped or fir-tree shaped. 11 Mathematical modelling has previously been used to try and make sense of bladder shape as it fills and empties; however, the clinical application of these methods to-date has been limited.…”
Section: Discussionmentioning
confidence: 99%
“…[7][8][9] Variations in bladder shape have been observed in association with detrusor overactivity during videourodynamics, when fluoroscopic images are captured during filling with contrast medium. 10,11 At one extreme, women with neuropathic OAB have been observed to have tense, spherical or dome-shaped bladders with trabeculations -'fir tree' or 'Christmas tree' bladder. 11 In women with normal detrusor muscle function, the bladder outline appears relaxed and acontractile, following the contours of the pelvis when assessed by cystography.…”
Section: Introductionmentioning
confidence: 99%
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“…A prospective study by Álvares et al on individuals who had suffered spinal cord injury (n = 34) showed that patients with greater maximum cystometric capacity responded significantly better than others (LE 2, GR B/C). 38 The authors also demonstrated that cystography parameters, including bladder shape, capacity and the presence of diverticula, were not significantly different between responders and non-responders to the therapy.…”
Section: Maximum Cystometric Capacitymentioning
confidence: 91%