A Pilot Prospective, Randomized, Placebo-Controlled Trial of Bilevel Positive Airway Pressure in Acute Asthmatic Attack

Soroksky, Arie; Stav, David; Shpirer, Isaac

doi:10.1378/chest.123.4.1018

Cited by 290 publications

(138 citation statements)

References 24 publications

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“…This is supported by the improvement in spirometry shown by Brandão et al 21 with a higher level of expiratory pressure. Soroksky et al 23 reported a more rapid improvement in FEV 1 during NIV. In that study, aerosol bronchodilators were given during interruption of NIV (ie, not in line with NIV).…”

Section: Asthmamentioning

confidence: 94%

Aerosol Therapy During Noninvasive Ventilation or High-Flow Nasal Cannula

Hess

2015

Respir Care

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Noninvasive ventilation (NIV) and high-flow nasal cannula (HFNC) are increasingly used for patients with acute respiratory failure. Some patients receiving these therapies might also benefit from inhaled drug delivery. Thus, it is attractive to combine aerosol therapy with NIV or HFNC. The purpose of this paper is to review the available evidence related to the use of inhaled aerosols with NIV or HFNC. Available evidence supports the delivery of aerosols during NIV. Inhaled bronchodilator response might be improved with the use of NIV in acute asthma, but the evidence is not sufficiently mature to recommend this as standard therapy. Evidence does support aerosol delivery without discontinuation of NIV. Clinical studies on aerosol delivery during HFNC are needed, and based on the available in vitro evidence, it is not possible to make a recommendation for or against aerosol delivery during HFNC.

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Section: Asthmamentioning

confidence: 94%

Aerosol Therapy During Noninvasive Ventilation or High-Flow Nasal Cannula

Hess

2015

Respir Care

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“…34 The second trial was a single-centre trial of 33 patients that used sham noninvasive ventilation in the control group. 35 None of the patients were intubated, and all survived the hospital stay. However, there was a more rapid improvement in the forced expiratory volume in the first second ( paring two pressure levels of noninvasive positive-pressure ventilation with oxygen therapy alone, a greater reduction in dyspnea and a greater increase in FEV 1 were reported for the group that received noninvasive ventilation.…”

Section: Exacerbation Of Asthmamentioning

confidence: 99%

“…[34][35][36] One trial, which cited selection bias in patient enrolment leading to a small sample size (n = 35), found no differences in outcomes. 34 The second trial was a single-centre trial of 33 patients that used sham noninvasive ventilation in the control group.…”

Section: Exacerbation Of Asthmamentioning

confidence: 99%

Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting

Keenan¹,

Sinuff²,

Burns³

et al. 2011

Canadian Medical Association Journal

322

202

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“…[1][2][3][4] However, in clinical practice, NIV is used beyond guideline recommendations, 5 and despite concerns about the effi- cacy of NIV as supportive therapy in ARF in patients with preexisting conditions other than COPD, NIV is broadly considered as the first line of respiratory support in patients with bronchiectasis, 6,7 rib cage or parenchymal restrictive diseases, [8][9][10] obesity, 11 or asthma. 12,13 Studies showed that, over the period 1998 -2008, NIV was increasingly used in patients suffering from COPD. 14, 15 Schnell et al 16 showed recently, in a multi-center database study of subjects who required ventilatory support for ARF between 1997 and 2011, that use of NIV improved outcomes in subjects with acute or chronic respiratory failure.…”

Section: Introductionmentioning

confidence: 99%

Trends in Prevalence and Prognosis in Subjects With Acute Chronic Respiratory Failure Treated With Noninvasive and/or Invasive Ventilation

et al. 2014

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BACKGROUND:The pattern and outcome of noninvasive ventilation (NIV) use in patients with acute or chronic respiratory disease other than COPD is not well known. The aims of this study were to investigate trends over time in underlying respiratory diseases, use of NIV, and outcomes in COPD and non-COPD patients with acute respiratory failure. METHODS: We made a retrospective analysis of data recorded prospectively from 1,113 subjects admitted between 1998 and 2012. RESULTS: Subject diagnoses were distributed as follows: COPD, n ‫؍‬ 568 (51%); bilateral bronchiectasis, n ‫؍‬ 113 (10%); obesity, n ‫؍‬ 166 (15%); chronic diffuse interstitial lung disease, n ‫؍‬ 131 (12%); restrictive pulmonary disease, n ‫؍‬ 113 (10%); and asthma, n ‫؍‬ 22 (2%). The proportion of subjects with bilateral bronchiectasis significantly decreased (OR 0.91, 95% CI 0.865-0.951, P < .001), whereas the proportion of subjects with obesity increased (OR 1.03, 95% CI 1.001-1.063, P ‫؍‬ .049) over time. The use of NIV (OR 1.05, 95% CI 1.010 -1.090, P ‫؍‬ .01) and the proportion of subjects initially treated with NIV (OR 1.05, 95% CI 1.013-1.094, P ‫؍‬ .009) increased significantly in COPD subjects only. Time trend of mortality was not significant (OR 0.98, 95% CI 0.95-1.01, P ‫؍‬ .23), whereas the severity of illness in subjects significantly increased. Transition from NIV to invasive mechanical ventilation (IMV) (OR 2.05, 95% CI 1.36 -3.11, P ‫؍‬ < .001), IMV (OR 10.49, 95% CI 4.88 -10.56, P < .001) and diffuse interstitial lung disease (OR 10.63, 95% CI 5.43-20.83, P < .001) were independently associated with death in the ICU. CONCLUSIONS: Over time, respiratory diseases have changed in non-COPD subjects and trends in the use and efficacy of NIV differ between COPD and non-COPD subjects. Mortality remained stable while the severity of illness in subjects increased. In COPD and non-COPD subjects, transition from NIV to IMV was associated with a poorer prognosis.

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A Pilot Prospective, Randomized, Placebo-Controlled Trial of Bilevel Positive Airway Pressure in Acute Asthmatic Attack

Cited by 290 publications

References 24 publications

Aerosol Therapy During Noninvasive Ventilation or High-Flow Nasal Cannula

Aerosol Therapy During Noninvasive Ventilation or High-Flow Nasal Cannula

Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting

Trends in Prevalence and Prognosis in Subjects With Acute Chronic Respiratory Failure Treated With Noninvasive and/or Invasive Ventilation

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