A Piezoelectric Immunosensor for the Detection of Cortisol

Bs, Attili; Aa, Suleiman

doi:10.1080/00032719508000035

Cited by 45 publications

(9 citation statements)

References 18 publications

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“…The recommendation was made that the device should be termed a thickness shear-mode (TSM) sensor. During the 1980s and 1990s, a large number of publications appeared concerning applications of piezoelectric-based biosensors, such as the detection of organic vapors (Guilbault and Luong 1988), environmental pollutants (Guilbault and Ngeh-Ngwainbi 1988;Guilbault et al 1992), clinical diagnostics (Plomer et al 1992;Kö sslinger et al 1994;Attili and Suleiman 1995), nucleic acid hybridization (Su et al, 1994), and pharmaceuticals and drug analysis (Nie, Wang, et al 1992;Wei et al 1993;Attili and Suleiman 1996). In earlier days, this type of biosensor was said to display excellent performance with an on-surface limit of detection as low as 0.015 mg (Nie, Zhang, et al 1992).…”

Section: Advent Of the Aw Biosensormentioning

confidence: 99%

Acoustic Wave-Based Detection in Bioanalytical Chemistry: Competition for Surface Plasmon Resonance?

2008

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A concise overview of selected literature concerning biosensors based on surface plasmon resonance and acoustic wave technologies is presented. A comparison in terms of their performance and potential advances in the bioanalytical field is discussed. This Mini-Review highlights the generally underrecognized potential of acoustic wave technology, in the field of biosensors relative to plasmon resonance, and focuses on stimulating not only the development of acoustic wave biosensors but also a broader and increased use of them. These sensors are anticipated to play a central role in biodetection in the near future.

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Section: Advent Of the Aw Biosensormentioning

confidence: 99%

Acoustic Wave-Based Detection in Bioanalytical Chemistry: Competition for Surface Plasmon Resonance?

2008

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“…IgM could be detected in the range of 5-93 //g/ml; the measurements were in satisfactory agreement with an established immunodiffusion procedure. Finally, a QCM system was also applied for the determinations of insulin [69] and cortisol [70] in buffer solutions and of IgA in saliva [71].…”

Section: Piezoelectric Systemsmentioning

confidence: 99%

Immunosensor Technology - Principles and Applications. Immunosensor-Technologie - Grundlagen und Anwendungen

Luppa¹

2001

LaboratoriumsMedizin

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Immunosensors are affinity ligand-based biosensor solid-state devices in which the immunochemical reaction is coupled to a transducer. The fundamental basis of all immunosensors is the specificity of the molecular recognition of antigens by antibodies to form a stable complex. This is similar to immunoassny methodology. Immunosensors can be categorized based on the detection principle applied. The main developments are electrochemical, optical, and microgravimetric immunosensors. In contrast to immunoassay, modern transducer technology enables the label-free detection and quantification of the immune complex. The analysis of trace substances in environmental science, pharmaceutical and food industries is a challenge since many of these applications demand a continuous monitoring mode. The use of immunosensors in these applications is most appropriate. Similarly, a series of clinical problems may be solved by continuous monitoring of certain analytes. Hence, clinical chemists should take advantage of immunosensors in clinical diagnostics. Therefore, the aim of this review is to portray the recent developments in the immunosensor field and their potential impacts in clinical diagnostics.

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“…Among these, adsorption of antibodies [56,57] and precoatings of either protein-A [58] or protein-G [59] have been used, with or without previous silanization as the activation step [60]. Among these, adsorption of antibodies [56,57] and precoatings of either protein-A [58] or protein-G [59] have been used, with or without previous silanization as the activation step [60].…”

Section: Piezoelectricmentioning

confidence: 99%

Immunosensors for Diagnostics

2001

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Immunosensors can play an important role in the improvement of public health by providing applications for which rapid detection, high sensitivity, and specificity are important, in areas such as clinical chemistry, food quality, and environmental monitoring. The standard immunoassay techniques are the basis for the development of improved automated devices, exploring the accumulated know how of the implementation of indirect detection methods during the last 40 years. Today's systems achieve high accuracy, specificity, and sample throughput. Disposable immunotests (qualitative and quantitative), based on colored detection of an immunoreaction, are continuously expanding its applications for diagnosis of diseases, drug detection, and food quality control.Associated to the increasing demand of immunoapplications and with the new advances produced in the last decades in fields like biochemistry, biotechnology, electronics, and microfabrication, new transduction devices have been developed and applied to monitor immunoreactions. Optimization of the biochemical characteristics of the binding molecules, improved surface stability of the transducer interfaces, and reliable microsystems and integrated devices are the challenge for the next years of development. An overview of the immunoassay techniques used today in standard diagnosis will be presented, including a brief description of the different immunosensor transducers and some examples of the present developments and commercial devices.

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A Piezoelectric Immunosensor for the Detection of Cortisol

Cited by 45 publications

References 18 publications

Acoustic Wave-Based Detection in Bioanalytical Chemistry: Competition for Surface Plasmon Resonance?

Acoustic Wave-Based Detection in Bioanalytical Chemistry: Competition for Surface Plasmon Resonance?

Immunosensor Technology - Principles and Applications. Immunosensor-Technologie - Grundlagen und Anwendungen

Immunosensors for Diagnostics

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