A Phytochemical Study of Xanthium Canadense††This paper is based on a thesis submitted by Norbert R. Kuzel, American Foundation for Pharmaceutical Education Fellow, to the Graduate Council of North Dakota State College in partial fulfillment of the requirements for the degree of Master of Science.

Kuzel, Norbert R.; Miller, Clifton E.

doi:10.1002/jps.3030390405

Cited by 15 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They reportedly reproduced the toxic effects of Xanthium poisoning found in the field with hydroquinone. Using the reported method of Kuzel and Miller (1950) followed by TLC analyses, we were unable to detect any hydroquinone in X. strumarium. Furthermore, we failed to reproduce the typical lesions of Xanthium toxicity after oral administration of authentic hydroquinone at levels up to twice the lethal dose (350 mg/kg) reported by Kuzel and Miller (1950).…”

Section: Resultsmentioning

confidence: 74%

“…Using the reported method of Kuzel and Miller (1950) followed by TLC analyses, we were unable to detect any hydroquinone in X. strumarium. Furthermore, we failed to reproduce the typical lesions of Xanthium toxicity after oral administration of authentic hydroquinone at levels up to twice the lethal dose (350 mg/kg) reported by Kuzel and Miller (1950). Conversely, the clinical signs and typical lesions (ascites and hepatic lesions) produced by administration of cocklebur seedlings and purified carboxyatractyloside were indistinguishable from each other and from those observed in field cases.…”

Section: Resultsmentioning

confidence: 74%

“…They did not associate the hypoglycemic properties of carboxyatractyloside with the specific diagnostic changes in swine caused by cocklebur poisoning. Kuzel and Miller (1950) reported that the toxic properties of the various species of Xanthium were due to hydroquinone. They reportedly reproduced the toxic effects of Xanthium poisoning found in the field with hydroquinone.…”

Section: Resultsmentioning

confidence: 99%

“…More recently, Kuzel and Miller (1950) reported that the toxicity of the various species of Xanthium was due to hydroquinone present in the kernel and bur. We reexamined the etiologic agent in cocklebur as a result of an outbreak of cocklebur poisoning in South Georgia in the early spring of 1978.…”

mentioning

confidence: 99%

“…The minimum quantity detectable by this system was ~1.5 jug of carboxyatractyloside. Analyses for hydroquinone were done according to the method of Kuzel and Miller (1950) and supplemented by TLC analyses.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Isolation and redefinition of the toxic agent from cocklebur (Xanthium strumarium)

Cole¹,

Stuart²,

Lansden³

et al. 1980

J. Agric. Food Chem.

View full text Add to dashboard Cite

Isolation and Redefinition of the Toxic Agent from Cocklebur (Xanthium strumarium)The highly toxic agent responsible for the poisonous properties of cocklebur, a common weed, has been isolated and identified as carboxyatractyloside. The toxin was identified by spectroscopic and chemical comparisons with authentic carboxyatractyloside.Cocklebur plants, Xanthium spp., are widely distributed in the United States and are found in nearly all parts of the world. The plants have become especially noxious in South Africa and Australia. The poisonous properties of cocklebur are found only in seed and very young seedlings that still contain the cotyledon (cotyledon stage) (Marsh and Roe, 1924). Very young cocklebur seedlings, growing

show abstract

Section: Resultsmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations