A physical activity programme and its effects on insulin resistance and oxidative defense in obese male patients with type 2 diabetes mellitus

Lazarević, Gordana; Antić, Slobodan; Cvetković, Tatjana; Vlahović, Predrag; Tasić, I.; Stefanović, Vladisav

doi:10.1016/s1262-3636(07)70312-9

Cited by 59 publications

(42 citation statements)

References 39 publications

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“…The practice of regular physical activity has displayed a positive relationship with the improvement of glycaemic control in patients with DM2 through the diminution of fasting glycaemia [41, 72,132] and HbA1c [22,31,41,45,72,82,132,139]. However, some authors were unable to observe this association [117], which could be explained by the different methodology used (questionnaires) to determine physical activity levels.…”

Section: Ages and Regular Physical Activitymentioning

confidence: 99%

“…It can nevertheless be assumed that regular physical activity, as an integrated part of an active lifestyle, may influence the accumulation of AGEs in the organism because the amount of these compounds is conditioned by glycaemia levels [58]. Therefore, the improvements of glycaemic control in DM2 due to physical exercise, usually linked with the reduction of the peripheral resistance to insulin [37, 72,132], could attenuate the formation and accumulation of AGEs in the tissue.…”

Section: Ages and Regular Physical Activitymentioning

confidence: 99%

“…Regarding oxidative stress, it is assumed that regular physical activity contributes to an augmentation of the antioxidant capacity, facilitating a more efficient combat against the formation of ROS [39, 71,72,104]. However, when a subject is unaccustomed to exercise or when it is practised too intensively, it can induce considerable oxidative stress and damage to the exercised muscles, affecting capillaries, muscle fibres and connective tissue [44].…”

Section: Ages and Regular Physical Activitymentioning

confidence: 99%

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Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity

Magalhães

Appell

Duarte

2008

Eur Rev Aging Phys Act

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Section: Ages and Regular Physical Activitymentioning

confidence: 99%

Section: Ages and Regular Physical Activitymentioning

confidence: 99%

Section: Ages and Regular Physical Activitymentioning

confidence: 99%

See 1 more Smart Citation

Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity

Magalhães

Appell

Duarte

2008

Eur Rev Aging Phys Act

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“…Lifestyle intervention programs for T2DM have been previously verified in many controlled trials: PA shows better effects on glycemic control and blood pressure than other therapies alone (12,13). Resistance training (14), isolated aerobic exercise, (15) and the combination of them (16) can improve glycemic adjustments; overall, the beneficial effects of exercise on physical fitness, disease symptoms, and quality of life in T2DM are strong (17)(18)(19)(20)(21). However, despite all these evidences, most patients remain sedentary (22,23).…”

Section: Introductionmentioning

confidence: 98%

Associations among physical activity, comorbidities, depressive symptoms and health-related quality of life in type 2 diabetes

Daniele

Oliveira

Pompeu

et al. 2013

Arq Bras Endocrinol Metab

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Objective: To investigate associations between physical activity, comorbidity severity, depressive symptoms, and health-related quality of life in type 2 diabetes mellitus. Subjects and methods: All individuals, 200 patients and 50 controls, aged from 40 to 60 years, were investigated by interview, and all variables were measured concurrently. Physical activity was evaluated by the International Physical Activity Questionnaire (IPAQ), Health-Related Quality of Life (HRQL) by the Short-Form Health Survey (SF-36), comorbidity severity by the Charlson Comorbidity Index (CCI), and depressive symptoms by the Beck Depression Inventory (BDI-II ≥ 16). Single and multiple regression analysis evaluated the effects of independent variables on physical activity. Results: The patients had more depressive symptoms and greater comorbidity severity (p < 0.005). Diabetic patients showed better activity levels (IPAQ) (p < 0.005). Functional Capacity, General State of Health, and Physical Limitation were the most affected subscales in the SF-36 evaluation of the HRQL. Sedentary diabetic patients had higher waist circumference, waist-to-hip ratios, more depressive symptoms, and worse HRQL. Functional capacity (p = 0.000), followed by General State of Health (p = 0.02), were the health status measure subscales independently associated with physical activity. Conclusions: The findings suggest that increasing patient independence and treating depressive symptoms can promote physical activity for type 2 diabetes mellitus patients. It is suggested that group activities and caregivers/family support might compensate for the patient dependence, and increase adherence to exercise programs in those that are less active. Arq Bras Endocrinol Metab. 2013;57(1):44-50 Keywords Type 2 diabetes; physical activity; quality of life; depressive symptoms; functional capacity RESUMO Objetivo: Investigar as associações entre atividade física, gravidade das comorbidades, sintomas depressivos e qualidade de vida relacionada à saúde em pacientes com diabetes mellitus tipo 2. Sujeitos e métodos: Todos os indivíduos, 200 pacientes e 50 controles, com idades entre 40 e 60 anos, foram analisados por entrevistas, e todas as variáveis foram medidas neste mesmo momento. A atividade física foi avaliada pelo International Physical Activity Questionnaire (IPAQ); a qualidade de vida relacionada à saúde (QVRS), pelo Short-Form Health Survey (SF-36); a gravidade das comorbidades, pelo Índice de Comorbidade de Charlson (CCI); e os sintomas depressivos foram avaliados pelo Inventário de Depressão de Beck (BDI-II ≥ 16). A análise de regressão simples e múltipla avaliou os efeitos das variáveis independentes sobre a atividade física. Resultados: Os pacientes apresentaram mais sintomas depressivos e maior gravidade das comorbidades (p < 0,005). Os pacientes diabéticos apresentaram melhores níveis de atividade (IPAQ) (p < 0,005). A Capacidade Funcional, a Condição Geral de Saúde e a Limitação Física foram as subescalas mais afetadas na avaliação da QVRS no SF-36. Os ...

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“…Ryo Miyazaki 1,2,3) , Yoshikazu Yonei 1) , Yoriko Azuma 3) , Hitoshi Chiba 4) , Koichiro Hayashi 5) , Koji Yamatsu 6) previous studies assessed the effectiveness of physical activity programs on baPWV either using resistance training 9) or exercise at special facilities [10][11][12][13][14] . Such exercise programs are difficult for older people to complete at home without super vision.…”

Section: Relationship Between the Change In Daily Step Count And Bracmentioning

confidence: 99%

Relationship Between the Change in Daily Step Count and Brachial-Ankle Wave Velocity During a Pedometer-Based Physical Activity Program for Older Adults

et al. 2011

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Objective: To study the relationship between the change in the number of steps taken and brachial-ankle pulse wave velocity (baPWV) during a long-term pedometer-based physical activity program in healthy older adults. Methods: Sixty older adults participated in this 17-week program. Each subject was provided with a pedometer and was given a goal to walk a set number of steps/day. After five subjects were excluded because of insufficient step data, data from 55 subjects (19 men and 36 women; age range: 65-79 years, mean age: 71.3±3.7 years; mean body mass index [BMI]: 24.1±8.8 kg/m 2 ) were analyzed. Subjects were checked before and after the study. Each subject was informed of his or her vascular age, calculated from baPWV, at the start of the study. Results: Subjects were divided into four groups based on the results of baPWV. The group in which baPWV improved above a selected cut-off value (1,700 cm/s) revealed the largest increase in steps/day among groups. This increase (4837.7±1868.7 steps) was larger than in groups in which baPWV remained low (1406.7±2402.1 steps, p=0.036) and high (1678.2±2871.4 steps, p=0.059). In any group, age or initial steps/day did not influence the change in steps. Subjects classified as having an older vascular age than the actual age on the basis of initial baPWV walked further. Conclusion: An increase in steps/day might improve baPWV. Although walking is a low intensity physical activity, it can have an anti-atherosclerosis effect.

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A physical activity programme and its effects on insulin resistance and oxidative defense in obese male patients with type 2 diabetes mellitus

Cited by 59 publications

References 39 publications

Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity

Involvement of advanced glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity

Associations among physical activity, comorbidities, depressive symptoms and health-related quality of life in type 2 diabetes

Relationship Between the Change in Daily Step Count and Brachial-Ankle Wave Velocity During a Pedometer-Based Physical Activity Program for Older Adults

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