A photoresponsive and rod-shape nanocarrier: Single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped &amp; Ce6-doped mesoporous silica nanorods

Sun, Qiang; You, Qing; Pang, Xiaojuan; Tan, Xiaoxiao; Wang, Jinping; Liu, Li; Guo, Fang; Tan, Fengping; Li, Nan

doi:10.1016/j.biomaterials.2017.01.021

Cited by 129 publications

(78 citation statements)

References 49 publications

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“…Although many photosensitizing agents based on porphyrinic molecules yield good clinical outcomes in cancer treatment, the hydrophobicity of porphyrin derivatives limits its effective delivery in tumors . To alleviate this problem, mesoporous silica nanostructure materials , metal‐based nanoparticles and certain carbon materials have been developed as photosensitizing agents carriers to improve the efficacy. However, the poor water solubility, potential toxicity and side effects of these carriers' materials raise concerns about biosafety .…”

Section: Introductionmentioning

confidence: 99%

Graphene quantum dot based charge‐reversal nanomaterial for nucleus‐targeted drug delivery and efficiency controllable photodynamic therapy

Regmi

et al. 2019

Journal of Biophotonics

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Graphene quantum dots (GQDs), the new zero‐dimensional carbon nanomaterial, have been demonstrated as a promising material for biomedical applications due to its good biocompatibility and low toxicity. However, the integration of multiple therapeutic approaches into a nanosized platform based on the GQD has not been explored yet to our best knowledge. In this report, we regulate the generation of reactive oxygen species (ROS) when using the GQD as a photosensitizer by varying the doping amount of nitrogen atoms to achieve efficiency controllable photodynamic therapy. On the other hand, charge‐reversal (3‐Aminopropyl) triethoxysilane (APTES) was used to conjugate on the surface of GQD for nucleus targeting drug delivery for the first time. The treatment outcome of produced ROS and nucleus‐targeting drug delivery was investigated by fluorescence imaging. The results demonstrated that the N‐GQD‐DOX‐APTES in dual roles as a drug carrier and photosensitizer could achieve nucleus‐targeting delivery and strong ROS production simultaneously. This approach provides a promising strategy for the development of multifunctional therapy in one nano platform for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Graphene quantum dot based charge‐reversal nanomaterial for nucleus‐targeted drug delivery and efficiency controllable photodynamic therapy

Regmi

et al. 2019

Journal of Biophotonics

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“…Metal nanoparticles are therefore efficient mediums to convert photons to thermal energy. The remarkable photothermal effect of metal nanoparticles has since been applied in many fields, such as catalysis, solar energy harvest, optical switching, cancer therapy, and drug delivery . Yet this effect has not been explored on SWIR photodetection.…”

Section: Introductionmentioning

confidence: 99%

Short‐Wave Infrared Sensor by the Photothermal Effect of Colloidal Gold Nanorods

Xiang

Niu

Sebag

et al. 2018

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Photodetection in the short-wave infrared (SWIR) spectrum is a challenging task achieved often by costly low bandgap compound semiconductors involving highly toxic elements. In this work, an alternative low-cost approach is reported for SWIR sensors that rely on the plasmonic-induced photothermal effect of solution-processed colloidal gold nanorods (Au NRs). A series of uniform solution-processed Au NRs of various aspect ratios are prepared exhibiting a strong and well-defined longitudinal localized surface plasmon resonance (L-LSPR) maximum from 900 nm to 1.3 µm. A hybrid device structure is fabricated by applying Au NRs on the surface of a thermistor. Under a monochromatic illumination, hybrid Au-NR/thermistor devices exhibit a clear photoresponse in the form of photoinduced resistance drop in the wavelength window from 1.0 to 1.8 µm. The photoresponsivity of such hybrid devices reaches a maximum value of 4.44 × 10 Ω W at λ = 1.4 µm (intensity = 0.28 mW cm ), a wavelength in agreement with the L-LSPR of the Au NRs applied. Colloidal Au NRs, capable to perform fast conversion between photon absorption and thermal energy, thus open an interesting avenue for alternative low-cost SWIR photodetection.

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“…Typical examples include NIRF imaging, photoacoustic (PA) imaging, ultrasound (US) imaging, magnetic resonance (MR) imaging and positron emission tomography (PET) imaging. [20][21][22][23][24] Although traditional delivery formulations combined therapeutic agents and imaging agents into a nanoplatform, its potential toxicity, overly complicated design, and poor drug loading capacity of nanocarriers make this type of treatment far too impractical for clinical application. To solve this issue, nanotheranostics that are achieved directly from small molecules without any carrier have attracted great attention.…”

Section: Introductionmentioning

confidence: 99%

<p>Self-Assembly Nanoparticles for Overcoming Multidrug Resistance and Imaging-Guided Chemo-Photothermal Synergistic Cancer Therapy</p>

Gao¹,

Chen²,

Fakhri³

et al. 2020

IJN

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Background and Purpose: The development of multiple drug resistance (MDR) to chemotherapy and single modal therapy remains unsatisfied for the eradication of tumor, which are major obstacles in cancer therapy. This novel system with excellent characteristics for inhibition of P-glycoprotein (P-gp), and for near-infrared fluorescence (NIRF) imagingguided chemo-photothermal therapy (PTT), has been identified as a promising way to MDR and achieve synergistic cancer therapy. Methods: In this study, we successfully synthesized a multifunctional theranostic system, which was developed through FDA-approved self-assembling drugs, which contain anticancer drug doxorubicin (Dox), imaging and high photothermal conversion drug indocyanine green (ICG) and P-gp regulator TPGS (the system named T/Dox-ICG). We studied the characterization of T/Dox-ICG NPs, including the TEM, SEM, DLS, UV-vis-NIR, zeta potential, CLSM, in vitro FL imaging, in vitro photothermal effect, in vitro Dox and ICG release. We used CLSM to verify the location of intracellular distribution of Dox in SCG 7901/VCR cells, Western blot was performed to demonstrate the TPGS-mediated inhibition of P-gp. And, the cytotoxicity of materials against SCG 7901/VCR cells was studied by the MTT assay. Results: The TEM showed the T/Dox-ICG NPs had good monodispersity with diameters of 19.03 nm, Dox and ICG could be released constantly from T/Dox-ICG NPs in vitro. In vitro cell experiments demonstrated higher Dox accumulation and retention in the nucleus. Western blot showed TPGS could obviously inhibit the expression of P-gp. In vitro cytotoxicity assay showed more significant cytotoxicity on MDR cells (SCG 7901/VCR) with only 8.75% of cells surviving. Conclusion: MDR cancer therapy indicates that it may be important to develop a safer system that can simultaneously inhibit the drug transporters and monitor the delivery of chemotherapeutic agents, and combination therapy have raised widespread concern on tumor treatment.

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A photoresponsive and rod-shape nanocarrier: Single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped & Ce6-doped mesoporous silica nanorods

Cited by 129 publications

References 49 publications

Graphene quantum dot based charge‐reversal nanomaterial for nucleus‐targeted drug delivery and efficiency controllable photodynamic therapy

Graphene quantum dot based charge‐reversal nanomaterial for nucleus‐targeted drug delivery and efficiency controllable photodynamic therapy

Short‐Wave Infrared Sensor by the Photothermal Effect of Colloidal Gold Nanorods

<p>Self-Assembly Nanoparticles for Overcoming Multidrug Resistance and Imaging-Guided Chemo-Photothermal Synergistic Cancer Therapy</p>

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