A photodynamic-mediated glutamine metabolic intervention nanodrug for triple negative breast cancer therapy

Yu, Cancan; Wang, Ningning; Chen, Xiangwu; Jiang, Yue; Luan, Yuxia; Wen, Qin; Sha, Xianyi

doi:10.1016/j.mtbio.2023.100577

Cited by 9 publications

(11 citation statements)

References 40 publications

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“…Photothermal therapy [72] Indocyanine green (ICG) Photothermal therapy [73] Etoposide (VP-16) DNA replication and repair inhibitor [76] Olaparib PARP inhibitor, DNA repair damage Glutamine starvation [92] Compound 968 (C968) Glutamine starvation [93] Genistein Glucose starvation [94] (Continues) Sorafenib Anti-angiogenesis therapy [111] Combretastatin A4 (CA4) Anti-angiogenesis therapy [112] co-assemble with Ce6 into rod-like SN38/Ce6 NPs and spherical-like SN38/Ce6 NPs. [51] The obtained SN38/Ce6 NPs exhibited high drug loading content, excellent stability and high tumor accumulation, which facilitated synergistic chemo-photodynamic therapy under light illumination.…”

Section: Cabazitaxel Dimer Linked With Thioketal Linkermentioning

confidence: 99%

“…[91] Similarly, the glutamine hydrolysis inhibitor Bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2yl) ethyl sulfide (BPTES) can self-assemble with Ce6 and achieve remarkable antitumor efficacy in a breast cancer mouse model via sensitized PDT. [92] In the study, human serum albumin was utilized to increase the stability and biocompatibility of the system. The same strategy exploiting inhibition of the activity of glutaminase for sensitized PDT was further employed via co-assembly of Ce6 and glutaminase inhibitor compound 968 (C968).…”

Section: 16mentioning

confidence: 99%

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Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Liu,

Xu,

Lyu

et al. 2023

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Nowadays, cancer has become the leading cause of death worldwide, driving the need for effective therapeutics to improve patient prognosis. Photodynamic therapy (PDT) has been widely applied as an antitumor modality, owing to its minimal invasiveness, localized tumor damage, and high safety profile. However, its efficacy is limited by poor stability of photosensitizers, inadequate tumor accumulation, and a complex tumor microenvironment. To overcome these challenges, extensive endeavors have been made to explore the co‐assembly of the widely used photosensitizer chlorin e6 (Ce6) with various functional small molecules to enhance pharmacodynamic activity. This review provides a comprehensive overview of current studies on Ce6‐based nanoparticles for effective PDT and precise delivery of functional molecules. The self‐assembly mechanism will be discussed in detail, with a focus on potential strategies for combinational therapy with PDT.

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Section: Cabazitaxel Dimer Linked With Thioketal Linkermentioning

confidence: 99%

Section: 16mentioning

confidence: 99%

Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Liu,

Xu,

Lyu

et al. 2023

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“…29 Breast cancer with higher malignancy is more dependent on Gln. 30 It has been found that after Gln deprivation, the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in TNBC cells is significantly upregulated, and the Caspase-8 apoptosis pathway is activated, leading to cell apoptosis. 31,32 Therefore, taking advantage of the metabolic characteristics of the tumor cells, the Gln addiction phenotype can be used as a potential anti-tumor target in combination with pro-apoptotic TRAIL receptor agonists in Breast Cancer.…”

Section: Glutaminementioning

confidence: 99%

“…Pharmacological inhibitors of SLC1A5‐mediated transport significantly reduced Gln uptake in human breast cancer cell lines, leading to the suppression of mammalian target of rapamycin complex 1 (mTORC1) signaling, cell growth and cell cycle progression (Figure 1). 29 Breast cancer with higher malignancy is more dependent on Gln 30 . It has been found that after Gln deprivation, the expression of tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) in TNBC cells is significantly upregulated, and the Caspase‐8 apoptosis pathway is activated, leading to cell apoptosis 31,32 .…”

Section: Neaas In Breast Cancermentioning

confidence: 99%

Amino acids and their roles in tumor immunotherapy of breast cancer

Xia,

Zhu,

Zheng

et al. 2023

The Journal of Gene Medicine

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Breast cancer is the most commonly diagnosed cancer among women. The primary treatment options include surgery, radiotherapy, chemotherapy, targeted therapy and hormone therapy. The effectiveness of breast cancer therapy varies depending on the stage and aggressiveness of the cancer, as well as individual factors. Advances in early detection and improved treatments have significantly increased survival rates for breast cancer patients. Nevertheless, specific subtypes of breast cancer, particularly triple‐negative breast cancer, still lack effective treatment strategies. Thus, novel and effective therapeutic targets for breast cancer need to be explored. As substrates of protein synthesis, amino acids are important sources of energy and nutrition, only secondly to glucose. The rich supply of amino acids enables the tumor to maintain its proliferative competence through participation in energy generation, nucleoside synthesis and maintenance of cellular redox balance. Amino acids also play an important role in immune‐suppressive microenvironment formation. Thus, the biological effects of amino acids may change unexpectedly in tumor‐specific or oncogene‐dependent manners. In recent years, there has been significant progress in the study of amino acid metabolism, particularly in their potential application as therapeutic targets in breast cancer. In this review, we provide an update on amino acid metabolism and discuss the therapeutic implications of amino acids in breast cancer.

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“…41,42 Many researchers have proposed to encapsulate Ce6 into nanocarriers to improve its solubility and delivery efficiency to tumor cells, so as to enhance the therapeutic effect of PDT. 31,43,44 Cationic lipids are one of the most promising gene vectors, of which bola-type cationic lipids have shown promise as nanodrug delivery platforms in medicine. 45,46 Bolalipids are dumbbell-shaped molecules composed of one or two hydrophobic chains with two hydrophilic headgroups at both ends.…”

Section: Introductionmentioning

confidence: 99%

ROS-Responsive Bola-Lipid Nanoparticles as a Codelivery System for Gene/Photodynamic Combination Therapy

Zhao,

Zhang,

Tian

et al. 2024

Mol. Pharmaceutics

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The nonviral delivery systems that combine genes with photosensitizers for multimodal tumor gene/photodynamic therapy (PDT) have attracted much attention. In this study, a series of ROS-sensitive cationic bola-lipids were applied for the gene/ photosensitizer codelivery. Zn-DPA was introduced as a cationic headgroup to enhance DNA binding, while the hydrophobic linking chains may facilitate the formation of lipid nanoparticles (LNP) and the encapsulation of photosensitizer Ce6. The length of the hydrophobic chain played an important role in the gene transfection process, and 14-TDZn containing the longest chains showed better DNA condensation, gene transfection, and cellular uptake. 14-TDZn LNPs could well load photosensitizer Ce6 to form 14-TDC without a loss of gene delivery efficiency. 14-TDC was used for codelivery of p53 and Ce6 to achieve enhanced therapeutic effects on the tumor cell proliferation inhibition and apoptosis. Results showed that the codelivery system was more effective in the inhibition of tumor cell proliferation than individual p53 or Ce6 monotherapy. Mechanism studies showed that the production of ROS after Ce6 irradiation could increase the accumulation of p53 protein in tumor cells, thereby promoting caspase-3 activation and inducing apoptosis, indicating some synergistic effect. These results demonstrated that 14-TDC may serve as a promising nanocarrier for gene/PDT combination therapy.

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A photodynamic-mediated glutamine metabolic intervention nanodrug for triple negative breast cancer therapy

Cited by 9 publications

References 40 publications

Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Amino acids and their roles in tumor immunotherapy of breast cancer

ROS-Responsive Bola-Lipid Nanoparticles as a Codelivery System for Gene/Photodynamic Combination Therapy

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