A Phenyl Thioether‐Based Probe: Zn²⁺ Ion Sensor, Structure Determination and Live Cell Imaging^†

Abstract

3,3′‐((1Z,1′Z)‐(((Propane‐1,3‐diylbis(sulfanediyl))bis(2,1‐phenylene))bis(azanyyldiene))bis(methanylylidene))bis(2‐hydroxy‐5‐methylbenzaldehyde) (H2‐SAP), characterized by different spectroscopic data, exhibits yellow emission (λem, 560 nm) when binds with Zn2+ in H2O‐MeOH (1:9 v/v, HEPES buffer, pH 7.4) in a mixture of seventeen biologically important other metal ions. The limit of detection (LOD) is 9.0 nM which is far below the World Health Organization (WHO) recommended data. The composition of the complex, 1:1 Zn2+:SAP2−, is supported by Job's plot, ESI‐MS and single crystal X‐Ray crystallographic structure. Intracellular Zn2+ ion is detected in Vero Cells (African Green Monkey Kidney) by using the probe, H2‐SAP, in the cell lines under fluorescence microscope. The probe has successfully been applied to recover Zn2+ in surface water.

Metal–organic frameworks (MOFs) as apt luminescent probes for the detection of biochemical analytes

“…In addition, Zn 2+ is an important indicator of the nutrient content of food. 63 Therefore, the development of a sensitive and selective probe for the detection of Zn 2+ is of great importance. In recent years, the development in luminescence technology has opened up new avenues for the detection of this ion.…”

Effect of ‐OMe Substituent on Salicylaldehyde Schiff Base to Influence the Zn2+ Sensitivity and the Cancer Cell Line Imaging

“…The fluorescent sensors have numerous advantages over other optical sensors because of their high sensitivity, easy to handling and real‐time monitoring with fast response time . Zinc, the second most abundant metal ion in human body, plays a decisive role in the activity of several enzymes and is also an important component of gene expression, some transcription factors, neurotransmission, apoptosis and onwards . Again, surplus of Zn is also injurious and causes Alzheimer's and Parkinson's disease .…”