A phenothiazine–rhodamine ratiometric fluorescent probe for Hg2+ based on FRET and ICT

Zhao, Wenqi; Liu, Xingliang; Lv, Haitang; Fu, Hua; Yang, Yan; Huang, Ziping; Han, Aijun

doi:10.1016/j.tetlet.2015.05.045

Cited by 37 publications

(10 citation statements)

References 40 publications

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“…The tridentate chelation of BPA forms 1:1 complex with Cd 2+ ion, as also reported in other studies wherein the same chelator was used [ 29 ]. The 1:1 chelation stoichiometry was also confirmed in this study through a Job’s plot approach [ 44 ], as shown in Figure 4 . Job’s plot is commonly used to determine the stoichiometry of a complex between two species, for which the total molar concentrations of the two species (here molecule 1 and Cd 2+ ion) are kept constant, while their relative concentrations are varied.…”

Section: Resultssupporting

confidence: 77%

A Ratiometric Fluorescent Sensor for Cd2+ Based on Internal Charge Transfer

Cheng

Liu

Xie

et al. 2017

Sensors

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This work reports on a novel fluorescent sensor 1 for Cd2+ ion based on the fluorophore of tetramethyl substituted bis(difluoroboron)-1,2-bis[(1H-pyrrol-2-yl)methylene]hydrazine (Me4BOPHY), which is modified with an electron donor moiety of N,N-bis(pyridin-2-ylmethyl)benzenamine. Sensor 1 has absorption and emission in visible region, at 550 nm and 675 nm, respectively. The long wavelength spectral response makes it easier to fabricate the fluorescence detector. The sensor mechanism is based on the tunable internal charge transfer (ICT) transition of molecule 1. Binding of Cd2+ ion quenches the ICT transition, but turns on the π − π transition of the fluorophore, thus enabling ratiometric fluorescence sensing. The limit of detection (LOD) was projected down to 0.77 ppb, which is far below the safety value (3 ppb) set for drinking water by World Health Organization. The sensor also demonstrates a high selectivity towards Cd2+ in comparison to other interferent metal ions.

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Section: Resultssupporting

confidence: 77%

A Ratiometric Fluorescent Sensor for Cd2+ Based on Internal Charge Transfer

Cheng

Liu

Xie

et al. 2017

Sensors

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“…The new band at 608 nm represented the spirolactam ring‐opening effect of rhodamine due to binding with Zn 2+ ion, thereby extending conjugation of the system and a green to pinkish red emission transformation (Figure S9). Fluorescence changes in PTRH following addition of other metal ions was not significantly discriminative; this finding showed the selective nature of the PTRH probe for Zn 2+ ions in solution …”

Section: Resultsmentioning

confidence: 73%

Phenothiazine–rhodamine‐based colorimetric and fluorogenic ‘turn‐on' sensor for Zn²⁺ and bioimaging studies in live cells

et al. 2019

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A phenothiazine-rhodamine (PTRH) fluorescent dyad was synthesized and its ability to selectively sense Zn 2+ ions in solution and in in vitro cell lines was tested using various techniques. When compared with other competing metal ions, the PTRH probe showed the high selectivity for Zn 2+ ions that was supported by electronic and emission spectral analyses. The emission band at 528 nm for the PTRH probe indicated the ring closed form of PTRH, as for Zn 2+ ion binding to PTRH, the λ em get shift to 608 nm was accompanied by a pale yellow to pink colour (under visible light) and green to pinkish red fluorescence emission (under UV light) due to ring opening of the spirolactam moiety in the PTRH ligand. Spectral overlap of the donor emission band and the absorption band of the ring opened form of the acceptor moiety contributed towards the fluorescence resonance energy transfer ON mechanism for Zn 2+ ion detection. The PTRH sensor had the lowest detection limit for Zn 2+ , found to be 2.89 × 10 −8 M. The sensor also demonstrated good sensing application with minimum toxicity for in vitro analyses using HeLa cells.

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“…The sensitive fluorescence quenching of Probe 1 by the Cu 2+ ions provided a way to determine the chelation stoichiometry between the two species simply through a Job plot approach, as shown in Figure 2 [ 31 ]. A Job plot is commonly used to determine the stoichiometry of a binding event between two species in a solution.…”

Section: Resultsmentioning

confidence: 99%

A Cu2+-Selective Probe Based on Phenanthro-Imidazole Derivative

Cheng

Liu

Yang

et al. 2016

Sensors

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A novel fluorescent Probe 1, based on phenanthro-imidazole has been developed as an efficient chemosensor for the trace detection of copper ions (Cu2+). Probe 1 demonstrated sensitive fluorescence quenching upon binding with Cu2+ through 1:1 stoichiometric chelation. The detection limit for Cu2+ ions was projected through linear quenching fitting to be as low as 2.77 × 10−8 M (or 1.77 ppb). The sensing response was highly selective towards Cu2+ with minimal influence from other common metal ions, facilitating the practical application of Probe 1 in trace detection.

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A phenothiazine–rhodamine ratiometric fluorescent probe for Hg2+ based on FRET and ICT

Cited by 37 publications

References 40 publications

A Ratiometric Fluorescent Sensor for Cd2+ Based on Internal Charge Transfer

A Ratiometric Fluorescent Sensor for Cd2+ Based on Internal Charge Transfer

Phenothiazine–rhodamine‐based colorimetric and fluorogenic ‘turn‐on' sensor for Zn²⁺ and bioimaging studies in live cells

A Cu2+-Selective Probe Based on Phenanthro-Imidazole Derivative

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A phenothiazine–rhodamine ratiometric fluorescent probe for Hg2+ based on FRET and ICT

Cited by 37 publications

References 40 publications

A Ratiometric Fluorescent Sensor for Cd2+ Based on Internal Charge Transfer

A Ratiometric Fluorescent Sensor for Cd2+ Based on Internal Charge Transfer

Phenothiazine–rhodamine‐based colorimetric and fluorogenic ‘turn‐on' sensor for Zn2+ and bioimaging studies in live cells

A Cu2+-Selective Probe Based on Phenanthro-Imidazole Derivative

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Phenothiazine–rhodamine‐based colorimetric and fluorogenic ‘turn‐on' sensor for Zn²⁺ and bioimaging studies in live cells