A PhC-SOA based cancerous cell detection biosensor

Abstract

In this paper, we present a novel method to design an ultra-small photonic integrated biosensor to detect cancerous cells. The proposed biosensor is based on the self-phase modulation in PhC-SOA, inducing a frequency shift on a pulse traveling through the device. The amount of the frequency chirp depends on the group velocity of the active medium waveguide being determined by the refractive index of the microfluidic infiltrating the holes around the waveguide. The refractive index of the microfluidic is also determined by the cell type that can be normal or cancerous. Since the refractive index of a cancerous cell is higher than that of a normal one, the group index of the waveguide and the output chirp will decrease. By measuring the amount of the output chirp, we can detect the cell type. The Simulation results showed that for a 0.02 change in the refractive index of the cell, a 3.71 nm central wavelength shift occurred for a 10-ps 71-mW gaussian pulse input with a central wavelength of 1533.53876 nm. In terms of the wavelength shift, the sensitivity and figure of merit are 185.5 and 530, respectively. To detect the cell type, we integrated a PhC channel drop filter to drop the chirped signal due to the cancerous cell infiltration. Designing an appropriate PhC-CDF leads to achieving an ultra-small cancerous detection cell biosensor with more than 97% precision.