A phase of increased ST elevation during coronary occlusion following ischemic preconditioning

Mortensen, Ulrik Markus; Nørgaard, Bjarne Linde; Nielsen‐Kudsk, Jens Erik; Kristensen, Jens; Mæng, Michael; Nielsen, Torsten Toftegaard

doi:10.1007/s00395-005-0574-z

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…Finally, the porcine model, as compared to rodent models, may be less sensitive for demonstrating cardioprotection. We have, however, previously demonstrated myocardioprotective effects in our porcine model [ 14 , 22 ].…”

Section: Discussionmentioning

confidence: 97%

“…Automatic computerized Vector-electrocardiography (Midas, Ortivus, Täby, Sweden) was used to monitor the magnitude of ST vector deviations during the entire procedure [ 14 ]. We thereby had an effective control of persistent occlusion during ischemia and reperfusion and procedure-related unwanted ischemic complications would therefore be readily detected.…”

Section: Methodsmentioning

confidence: 99%

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Lack of cardioprotection from subcutaneously and preischemic administered Liraglutide in a closed chest porcine ischemia reperfusion model

Kristensen

Mortensen

Schmidt

et al. 2009

BMC Cardiovasc Disord

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Background: Glucagon-like peptide 1 (GLP1) analogues are promising new treatment options for patients with type 2 diabetes, but may have both potentially beneficial and harmful cardiovascular effects. This may also be the case for the analogues of GLP1 for clinical use. The present study examined the effect of treatment with Liraglutide, a long-acting GLP1 analogue, on myocardial ischemia and reperfusion in a porcine model.

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Section: Discussionmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Lack of cardioprotection from subcutaneously and preischemic administered Liraglutide in a closed chest porcine ischemia reperfusion model

Kristensen

Mortensen

Schmidt

et al. 2009

BMC Cardiovasc Disord

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“…The ST vector magnitude was shown to increase during preconditioning cycles of local cardiac ischemia-reperfusion stimuli [ 26 ]. Interestingly, we found that ST level was elevated after RLIPC before any cardiac manipulation.…”

Section: Discussionmentioning

confidence: 99%

Remote Liver Ischemic Preconditioning Protects against Sudden Cardiac Death via an ERK/GSK-3β-Dependent Mechanism

et al. 2016

PLoS ONE

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BackgroundPreconditioning stimuli conducted in remote organs can protect the heart against subsequent ischemic injury, but effects on arrhythmogenesis and sudden cardiac death (SCD) are unclear. Here, we investigated the effect of remote liver ischemia preconditioning (RLIPC) on ischemia/reperfusion (I/R)-induced cardiac arrhythmia and sudden cardiac death (SCD) in vivo, and determined the potential role of ERK/GSK-3βsignaling.Methods/ResultsMale Sprague Dawley rats were randomized to sham-operated, control, or RLIPC groups. RLIPC was induced by alternating four 5-minute cycles of liver ischemia with 5-minute intermittent reperfusions. To investigate I/R-induced arrhythmogenesis, hearts in each group were subsequently subjected to 5-minute left main coronary artery ligation followed by 20-minute reperfusion. RLIPC reduced post-I/R ventricular arrhythmias, and decreased the incidence of SCD >threefold. RLIPC increased phosphorylation of cardiac ERK1/2, and GSK-3β Ser9 but not Tyr216 post-I/R injury. Inhibition of either GSK-3β (with SB216763) or ERK1/2 (with U0126) abolished RLIPC-induced antiarrhythmic activity and GSK-3β Ser9 and ERK1/2 phosphorylation, leaving GSK-3β Tyr216 phosphorylation unchanged.ConclusionsRLIPC exerts a powerful antiarrhythmic effect and reduces predisposition to post-IR SCD. The underlying mechanism of RLIPC cardioprotection against I/R-induced early arrhythmogenesis may involve ERK1/2/GSK-3β Ser9-dependent pathways.

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“…By inflation of the balloon, severe coronary occlusion was generated. Balloon position and flow obstruction were verified by angiography immediately after balloon inflation 15. The balloon was inflated to 6–8 atm for 2 hours.…”

Section: Methodsmentioning

confidence: 99%

Use of an intracoronary Doppler guidewire for evaluation of coronary hemodynamics in the porcine model of acute hibernating myocardium during dobutamine stress tests

Pan

Xia

et al. 2011

J of Clinical Ultrasound

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A phase of increased ST elevation during coronary occlusion following ischemic preconditioning

Abstract: Ischemic preconditioning reduced and delayed early ST elevation during subsequent coronary artery occlusion, but increased late ST elevation. Thus, ischemic preconditioning causes a dynamic and critically time-dependent biphasic pattern of ST elevation during repeated coronary occlusions.

Cited by 4 publications

References 35 publications

Lack of cardioprotection from subcutaneously and preischemic administered Liraglutide in a closed chest porcine ischemia reperfusion model

Lack of cardioprotection from subcutaneously and preischemic administered Liraglutide in a closed chest porcine ischemia reperfusion model

Remote Liver Ischemic Preconditioning Protects against Sudden Cardiac Death via an ERK/GSK-3β-Dependent Mechanism

Use of an intracoronary Doppler guidewire for evaluation of coronary hemodynamics in the porcine model of acute hibernating myocardium during dobutamine stress tests

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