A Phase I Clinical Trial of the Treatment of Crohn's Fistula by Adipose Mesenchymal Stem Cell Transplantation

Garcı́a-Olmo, Damián; García-Arranz, Mariano; Herreros, Dolores; Pascual, Isabel; Peiró, Concepción; Rodríguez-Montes, José Antonio

doi:10.1007/s10350-005-0052-6

Cited by 723 publications

(478 citation statements)

References 11 publications

(9 reference statements)

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“…In CD, MSCs have been tested in clinical trials for two indications, namely fistulizing and luminal disease [38][39][40][41][42][43][44][45][46]. In fistulizing disease, the differentiation potential of MSCs is thought to be of crucial importance to achieve fistula tract closure.…”

Section: Msc and Ibdmentioning

confidence: 99%

“…In fistulizing disease, the differentiation potential of MSCs is thought to be of crucial importance to achieve fistula tract closure. Encouraging results from studies using locally administered MSCs to treat complex perianal fistulae support the use of this approach for patients unresponsive to infliximab [38][39][40][41][42][43][44]. For luminal disease, the rationale for the use of MSCs lies mainly in their immunosuppressive capacity.…”

Section: Msc and Ibdmentioning

confidence: 99%

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Stem cell therapy for inflammatory bowel disease

2015

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Inflammatory bowel disease (IBD) could be curable by ''immune rest'' and correction of the genetic predisposition inherent in allogeneic hematopoietic stem cell transplantation. However, balancing risks against benefits remains challenging. The application of mesenchymal stem cells (MSCs) serving as a site-regulated ''drugstore'' is a recent concept, which suggests the possibility of an alternative treatment for many intractable diseases such as IBD. Depending on the required function of MSC, such as a cell provider, immune moderator, and/or trophic resource, MSC therapy should be optimized to maximize its therapeutic benefit. Therapeutic effects do not always require full engraftment of MSCs. Therefore, optimization of pleiotropic gut trophic factors produced by MSCs, which favoring not only regulating immune responses but also promoting tissue repair, must directly enhance new drug discoveries for treatment of IBD. Stem cell biology holds great promise for a new era of cell-based therapy, sparking considerable interest among scientists, clinicians, and patients. However, the translational arm of stem cell science remains in a relatively primitive state.Although several clinical studies using MSCs have been initiated, early results suggest several inherent problems. In each study, optimization of MSC therapy appears to be the most urgent problem, and can be resolved only by scientifically unveiling the mechanisms of therapeutic action. In the present review, the authors outline how such information would facilitate the critical steps in the paradigm shift from basic research on stem cell biology to clinical practice of regenerative medicine for conquering IBD in the near future.

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Section: Msc and Ibdmentioning

confidence: 99%

Section: Msc and Ibdmentioning

confidence: 99%

Stem cell therapy for inflammatory bowel disease

2015

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“…8 Other clinical studies have reported effects of MSC on gastrointestinal healing such as the reversion of colon peritonitis in patients with GVHD 9 or the treatment of rectovaginal and perianal fistulas in patients with Crohn's disease. 10 In the work reported here, the capability of MSC to induce a therapeutic benefit was analyzed in an experimental model using NOD/SCID mice with radiation-induced small intestinal damage. In this experimental model, we analyzed in vivo the potential of MSC treatment on cellular mechanisms of cell function restoration.…”

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confidence: 99%

Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis

et al. 2009

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Patients who undergo pelvic or abdominal radiotherapy may develop acute and/or chronic side effects resulting from gastrointestinal tract (GIT) alterations. In this study, we address the question of the regenerative capability of mesenchymal stem cells (MSC) after radiation-induced GIT injury. We also propose cellular targets of MSC therapy. We report that the infusion of human bone marrow-derived MSC (hMSC) provides a therapeutic benefit to NOD/SCID mice undergoing radiation-induced GIT failure. We observed that hMSC treatment brings about fast recovery of the small intestine (structure and function) in mice with reversible alterations and extends the life of mice with irreversible GIT disorders. The effects of hMSC are a consequence of their ability to improve the renewal capability of small intestinal epithelium. hMSC treatment favors the re-establishment of cellular homeostasis by both increasing endogenous proliferation processes (Ki67 immunostaining) and inhibiting apoptosis (TUNEL staining) of radiation-induced small intestinal epithelial cells. Our results suggest that MSC infusion may be used as a therapeutic treatment to limit radiation-induced GIT damage.

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“…Hastaların bir yıllık kontrolünde herhangi bir yan etki görülmedi¤i bildirilmitir. [36] Aynı grup faz II çalımasında uyguladıkları MKH ile fibrin yapıtırıcı kıyaslamılar ve MKH'nin etkinli¤inin daha fazla oldu¤unu göstermilerdir. [35] Yine aynı grubun 2012 yılında yaptıkları çalımada; allojenik AD-MKH uygulanmasını denemiler, altı aylık kontrollerde tedaviyle ilgili bir yan etki saptamadıklarını bildirmilerdir.…”

Section: Self-renewal (Kendini Yenileyebilme)unclassified

Stem cells; mesenchymal stem cells and current clinical applications

Tekeli¹

2016

FNG & Bilim Tıp Transplantasyon Dergisi

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Stem cells are defined as a type of cell that have the features of self-renewal, unlimited proliferation capacity, potential of differentiation into other cell types and ability to repair damaged structure when given to damaged tissue. Stem cells are preferred for regenerative medical applications because of their abundance, being easily obtained, ability to proliferate by differentiating into many cell types and being transplantable safely and effectively to recipients. In this review, we introduce mesenchymal stem cells as one of the most important sources of stem cells that have clinical applications and give examples of their usage areas in the clinic and of studies.Keywords: Clinical application; mesenchymal stem cells; stem cell. Stem cells; mesenchymal stem cells and current clinical applications ÖZKök hücreler; kendilerini yenileyebilme, sınırsız çoğalabilme, kendilerinden başka hücrelere farklılaşabilme, hasarlı dokuya verildiğinde hasarlı yapıyı onarabilme özellikleri ile tanımlanan hücre tipidir. Kök hücreler bol miktarda bulunmaları, kolay elde edilebilmeleri, birçok hücre tipine farklılaşarak çoğalabilmeleri, alıcılara güvenli ve etkin bir şekilde nakledilebilmeleri nedeniyle rejeneratif tıp uygulamalarında tercih edilmektedir. Bu derlemede, klinikte uygulamaları bulunan ve en önemli kök hücre kaynaklarından biri olan mezenkimal kök hücreler tanıtılacak, klinikteki kullanım alanları ve çalışmalardan örnekler verilecektir.

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A Phase I Clinical Trial of the Treatment of Crohn's Fistula by Adipose Mesenchymal Stem Cell Transplantation

Cited by 723 publications

References 11 publications

Stem cell therapy for inflammatory bowel disease

Stem cell therapy for inflammatory bowel disease

Mesenchymal stem cells improve small intestinal integrity through regulation of endogenous epithelial cell homeostasis

Stem cells; mesenchymal stem cells and current clinical applications

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