A Pharmacological Functional Magnetic Resonance Imaging Study Probing the Interface of Cognitive and Emotional Brain Systems in Pediatric Bipolar Disorder

Pavuluri, Mani N.; Passarotti, Alessandra M.; Parnes, Stephanie A.; Fitzgerald, Jacklynn M.; Sweeney, John A.

doi:10.1089/cap.2009.0105

Cited by 40 publications

(58 citation statements)

References 33 publications

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“…fMRI session: pediatric affective color-matching task After training in a mock scanner, participants completed the pediatric affective color-matching task for approximately ten minutes in the fMRI scanner (Passarotti et al 2010a;Pavuluri et al, , 2010Pavuluri et al, , 2011. On each trial, participants matched the color (red, green, yellow, or blue) of an emotional word, presented centrally for 200 msec, to either of two colored circles, presented to the left or right of the word for 3000 msec, with no inter-stimulus interval.…”

Section: Clinical Effects Of Treatment and Behavioral Analysesmentioning

confidence: 99%

“…While completing this task, patients showed limbic over-activity and decreased VLPFC activity in manic or euthymic states (Passarotti et al, 2010c;Pavuluri et al, , 2010. Treatment studies using lamotrigine (Pavuluri et al, 2010), or risperidone or divalproex have found that drug treatment normalizes the frontal activation dysfunction seen on this task in PBD, but that the amygdala and paralimbic over-activity remain a persistent problem for patients. The level of amygdala over-activity at baseline can also predict treatment outcome, as baseline amygdala overactivation predicted a poorer treatment outcome (higher mania scores) in patients .…”

Section: Introductionmentioning

confidence: 99%

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Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder

et al. 2011

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The aim of this study was to determine functional connectivity among patients with pediatric bipolar disorder (PBD) who are responders to pharmacotherapy and those who are nonresponders, and learn how they differ from healthy controls (HC) while performing a task that engages affective and cognitive neural systems. PBD participants (n = 34; 13.4 -2.3 years) were defined as responders if there was ‡ 50% improvement in Young Mania Rating Scale (YMRS) scores (n = 22) versus nonresponders with < 50% improvement (n = 12) with one of three mood stabilizing medications (divalproex, risperidone, or lamotrigine). HC (n = 14; 14.2 -3.1 years) participants also were scanned at baseline and follow-up. During functional magnetic resonance imaging, participants performed a color-matching task in which they had to match the color of positive, negative, or neutral words with colored dots. Independent component analysis was used to identify functionally connected networks across the whole brain, which were subsequently interrogated using region-of-interest analyses to test for group differences. A frontolimbic network was identified that showed impaired functional integration in PBD relative to HC when participants viewed negatively valenced words. PBD medication responders showed greater connectivity of the amygdala into the network before and after treatment compared with nonresponders, with responders showing a pattern more similar to HC than to nonresponders. Regardless of medication type, the degree of amygdala functional connectivity predicted medication response as well as the improvement in YMRS scores across responders and nonresponders. These findings suggest that increased functional integration of the amygdala within the frontolimbic network might be a biomarker of general mood stabilizer medication responsivity in bipolar disorder.

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Section: Clinical Effects Of Treatment and Behavioral Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder

et al. 2011

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“…Moreover, Previous studies have shown reduced activation of right rostral ventrolateral prefrontal cortex together with increased activity in anterior cingulate, amygdala, and paralimbic cortex in PBD patients compared to healthy controls using a variety of cognitive tasks [19,75,76]. In pediatric BD, one study reported abnormal fronto-amygdala iFC in youths during a manic state [18,88].…”

Section: International Archives Of Medicinementioning

confidence: 99%

“…This finding suggests the importance of adopting a dimensional approach towards suicidality in BD [66,74]. This risk may be particularly acute given the documented dysfunction in the brain structures involved in coping skills (e.g., reduced activation in the dorsolateral prefrontal cortex in concert with limbic overactivity) associated with PBD [7, [75][76][77], as well as the low self-esteem and hopelessness these youth report [7,72]. Thus, BD is one the most devastating of all psychiatric disorders in terms of risk for suicide, need for hospitalization and suffering [2].…”

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confidence: 99%

Bipolar disorder in children and adolescents: from the beginning to the consequences

Amorim¹,

Araújo²,

Oliveira³

et al. 2015

Int Arch Med

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Bipolar disorder (BD) is a condition characterized by an alternation between phases of depression and mania. Its beginning is influenced by both genetic and environmental factors, causing neurological and psychological changes. In children, it is manifested through episodes of mood disturbance and pronounced psychosocial impairment, causing sleeping disorders and presenting a high rate of suicidal ideals. It has a very complex treatment, since you cannot neglect or exacerbate neither the episodes of mania or depression, taking them both in consideration when choosing the right medication and monitoring the symptoms and response to treatment. It is also a disease which has not a well defined process of etiology and pathophysiology. This study is a current literature review of a recurrent disease in psychiatry.

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“…[41] Psikiyatride Güncel Yaklaşımlar -Current Approaches in Psychiatry İleriye dönük klinik çalışmalardaki fMRG sonuçlarına göre, bazı çalışma-larda prefrontal korteks ve temporal bölgelerdeki değişiklikler lamatrojin tedavisi ile normalleşmiştir. [42][43][44] Diğer uzunlamasına çalışmalarda amigdala ve prefrontal korteksteki değişiklikler ile klinik iyileşme arasında korelasyon bulunmuştur. [45,46] Fakat bu değişiklikler üzerinde tedavinin mi genel klinik iyileşmenin mi etkisi olduğu kesin değildir.…”

Section: Tedavinin Nöroradyolojik Bulguları üZerindeki Etkisiunclassified

Neuroradiological Imaging Studies in Bipolar Disorder

Kara¹,

Akarsu²,

Verim³

2012

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETBipolar bozukluk tekrarlayan ataklarla seyreden, işlevselliği belirgin olarak bozan kronik bir ruhsal bozukluktur. Nörobiyolojik temelleri olan hastalıkla ilgili birçok çalışma yapılmasına rağmen patofizyolojisi tam olarak bilinmemektedir. Yapısal ve işlevsel görüntüleme tekniklerinin, bipolar bozukluğun etyolojisinin daha iyi anlaşılmasına ve tanısal yaklaşımının gelişmesine belirgin katkısı olmuştur. Beyin görüntüleme modalitelerindeki güncel gelişmeler sayesinde hastalığın altında yatan nöral sistemlerdeki anormallikler hakkında bilinenler artmaktadır. Nörobilişsel ve duygusal alanlarda belirgin bozulma olan bu hastalıkta, nesnel biyobelirteçlerin tanımlanması bozukluğun patofizyolojisini aydınlatmakta fayda sağlayacaktır. Anahtar Sözcükler: Bipolar bozukluk, nörogörüntüleme, nörobiyoloji ABSTRACT Bipolar disorder is characterized by recurrent attacks, significantly disrupts the functionality of a chronic mental disorder. Although there is growing number of studies on the neurobiological basis of the disorder, the pathophysiology has not yet been clearly understood. Structural and functional imaging techniques present a better understanding of the etiology of bipolar disorder and has contributed significantly to the development of the diagnostic approach. Recent developments in brain imaging modalities have let us learn more about the underlying abnormalities in neural systems of bipolar patients. Identification of objective biomarkers would help to determine the pathophysiology of bipolar disorder, a disorder which causes significant deterioration in neurocognitive and emotional areas.

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A Pharmacological Functional Magnetic Resonance Imaging Study Probing the Interface of Cognitive and Emotional Brain Systems in Pediatric Bipolar Disorder

Cited by 40 publications

References 33 publications

Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder

Amygdala Functional Connectivity Predicts Pharmacotherapy Outcome in Pediatric Bipolar Disorder

Bipolar disorder in children and adolescents: from the beginning to the consequences

Neuroradiological Imaging Studies in Bipolar Disorder

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