A Pharmacologic Study of Devil's Club Root (Fatsia Horrida)

Piccoli, Leonard J.; Spinapolice, E B S Michael; Hecht, B S Morris

doi:10.1002/jps.3030290105

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…A, 1E). This dose is lower than what is found in the historical literature for anti‐diabetic studies performed with rabbits (Piccoli et al ., ). It is difficult to directly compare our dosage with traditional usage which relies on crude preparations and teas (Smith, ; Thommasen et al ., ), but our study dose likely was also substantially lower.…”

Section: Resultsmentioning

confidence: 97%

Extracts of Devil's Club (Oplopanax horridus) Exert Therapeutic Efficacy in Experimental Models of Acute Myeloid Leukemia

McGill

Alba-Rodriguez

et al. 2014

Phytotherapy Research

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Acute myeloid leukemia (AML) is a group of hematological malignancies defined by expanded clonal populations of immature progenitors (blasts) of myeloid phenotype in blood and bone marrow. Given a typical poor prognostic outlook, there is great need for novel agents with anti-AML activity. Devil’s club (Oplopanax horridus) is one of the most significant medicinal plants used among the indigenous people of Southeast Alaska and the coastal Pacific Northwest, with different linguistic groups utilizing various parts of the plant to treat many different conditions including cancer. Studies identifying medically relevant components in Devil’s club are limited. For this research study, samples were extracted in 70% ethanol before in vitro analysis, to assess effects on AML cell line viability as well as to study regulation of tyrosine phosphorylation and cysteine oxidation. The root extract displayed better in vitro anti-AML efficacy in addition to a noted anti-tyrosine kinase activity independent of an antioxidant effect. In vivo therapeutic studies using an immunocompetent murine model of AML further demonstrated that Devil’s club root extract improved the murine survival while decreasing immunosuppressive regulatory T cells and improving CD8+ T-cell functionality. This study defines for the first time an anti-AML efficacy for extracts of Devil’s club.

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Section: Resultsmentioning

confidence: 97%