A pharmaceutical study of doxorubicin-loaded PEGylated nanoparticles for magnetic drug targeting

Gautier, Juliette; Munnier, Emilie; Paillard, Archibald; Hervé, Katel; Douziech-Eyrolles, Laurence; Soucé, Martin; Dubois, Pierre; Chourpa, Igor

doi:10.1016/j.ijpharm.2011.06.010

Cited by 101 publications

(50 citation statements)

References 37 publications

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“…Several secondary mechanisms of DOX action are described as DOX-induced production of ROS. 2 Mitochondrially located ROS can also be detected rapidly after DOX administration, most probably due to respiratory chain-produced superoxide radicals. 20 One feature of DOX is to produce ROS via one-electron reduction to the corresponding semiquinone free radicals that then react rapidly with oxygen to generate superoxide radical anions.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 In addition to their magnetic properties, the high surface area to volume ratio and suitability for appropriate and broad surface functionalization provide the potential for high drug loading. 2,8,9 SPIO are finally biocompatible, biodegradable, and have a satisfactory safety profile. 10 Several SPIO/POLYMER/DOX composites have been developed and tested for their drug releasing properties at various pH values, temperature, or in the presence of external magnetic fields, followed by cell internalization studies and measurement of common cytotoxic assays.…”

mentioning

confidence: 99%

“…Thus, in view of this fact, when the cells are exposed to the MagAlg-DOX nanocarriers, it is expected that the whole composite is taken into the cells via endocytosis and then transported into acidic endosomes/lysosomes where controlled DOX release takes place. 2,8,12 While MagAlg-DOX accumulates throughout the cell and is concentrated in the perinuclear region 8 or cytoplasm, 12 free DOX accumulates in the cell nucleus. From our microscopic analysis, we observed faster uptake of free DOX compared with MagAlg-DOX.…”

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confidence: 99%

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In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines

Tománková¹,

Poláková²,

Pizova³

et al. 2015

IJN

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One of the promising strategies for improvement of cancer treatment is based on magnetic drug delivery systems, thus avoiding side effects of standard chemotherapies. Superparamagnetic iron oxide (SPIO) nanoparticles have ideal properties to become a targeted magnetic drug delivery contrast probes, named theranostics. We worked with SPIO condensed colloidal nanocrystal clusters (MagAlg) prepared through a new soft biomineralization route in the presence of alginate as the polymeric shell and loaded with doxorubicin (DOX). The aim of this work was to study the in vitro cytotoxicity of these new MagAlg–DOX systems on mouse fibroblast and breast carcinoma cell lines. For proper analysis and understanding of cell behavior after administration of MagAlg–DOX compared with free DOX, a complex set of in vitro tests, including production of reactive oxygen species, comet assay, cell cycle determination, gene expression, and cellular uptake, were utilized. It was found that the cytotoxic effect of MagAlg–DOX system is delayed compared to free DOX in both cell lines. This was attributed to the different mechanism of internalization of DOX and MagAlg–DOX into the cells, together with the fact that the drug is strongly bound on the drug nanocarriers. We discovered that nanoparticles can attenuate or even inhibit the effect of DOX, particularly in the tumor MCF7 cell line. This is a first comprehensive study on the cytotoxic effect of DOX-loaded SPIO compared with free DOX on healthy and cancer cell lines, as well as on the induced changes in gene expression.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines

Tománková¹,

Poláková²,

Pizova³

et al. 2015

IJN

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“…Among various other anticancer drugs, Doxorubicin (Dox) is widely used as a model drug. There are several methods that can be used to load Dox into nanoparticles, such as by adsorption onto nanocarrier inorganic core [93][94][95], by diffusion [95,96], or entrapment [97,98] in the coating materials and by chemical bonds [99,100] with the coating of the nanocarrier. Several modifications including surface functionalization of these SPIONs with Dox have been conducted over the last few years to investigate their efficacy [101].…”

Section: Spion For Drug Deliverymentioning

confidence: 99%

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Palihawadana-Arachchige¹,

Naik²,

Vaishnava³

et al. 2017

Nanostructured Materials - Fabrication to Applications

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Nanotechnology has facilitated the applications of a class of nanomaterials called superparamagnetic iron oxide nanoparticles (SPIONs) in cancer theranostics. This is a new discipline in biomedicine that combines therapy and diagnosis in one platform. The multifunctional SPIONs, which are capable of detecting, visualizing, and destroying the neoplastic cells with fewer side effects than the conventional therapies, are reviewed in this chapter for theranostic applications. The chapter summarizes the design parameters such as size, shape, coating, and target ligand functionalization of SPIONs, which enhance their ability to diagnose and treat cancer. The review discusses the methods of synthesizing SPIONs, their structural, morphological, and magnetic properties that are important for theranostics. The applications of SPIONs for drug delivery, magnetic resonance imaging, and magnetic hyperthermia therapy (MHT) are included. The results of our recent MHT study on Gd-doped SPION as a possible theranostic agent are highlighted. We have also discussed the challenges and outlook on the future research for theranostics in clinical settings.

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“…Magnetic nanoparticles (MPs) as a support are of great interest for researchers from a wide range of organic and/or inorganic compounds. [15][16][17][18][19] . Magnetic nanoparticles offer the benefit of taking the drug to the target using magnetic field.…”

Section: Introductionmentioning

confidence: 99%

Enteric Theophylline Delivery by a New Type of Polymer‐Grafted Magnetic Nanoparticles

Panahi

Soltani

2014

Adv Polym Technol

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Magnetite nanoparticles was synthesized and then grafted with polymer containing iminodiacetic acid for an interaction of theophylline. The resulted grafted magnetic nanosorbent was characterized with Fourier transform infrared spectroscopy, elemental analysis, thermogravimetric analysis, and scanning electron microscopy. The effects of sorption parameters such as sample pH, temperature, and contact time on sorption of theophylline were considered. The sorption capacity of functionalized sorbent was 27 mg g −1 . The profile of the theophylline uptake by the magnetic nanosorbent reflects good accessibility of the active sites in the grafted polymer. The equilibrium adsorption data of theophylline on grafted magnetic nanosorbent was analyzed by Langmuir, Freundlich, Temkin, and Redlich-Peterson. Nearly 75% of theophylline was released in simulated gastric fluid pH 1.2 in 110 min and 88% in simulated intestinal fluid pH 7.4 in 30 h. These results have shown the utility of the theophylline loaded-grafted magnetite nanoparticles for enteric drug delivery. C

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A pharmaceutical study of doxorubicin-loaded PEGylated nanoparticles for magnetic drug targeting

Cited by 101 publications

References 37 publications

In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines

In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Enteric Theophylline Delivery by a New Type of Polymer‐Grafted Magnetic Nanoparticles

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