A pH responsive complexation-based drug delivery system for oxaliplatin

Abstract

A responsive drug delivery system (DDS) for oxaliplatin (OX) has been designed with a view to overcoming several common drawbacks associated with this widely used anticancer agent, including fast degradation/deactivation in the blood stream, lack of tumor selectivity, and low bioavailability.

Pillarquinone‐Based Porous Polymer for a Highly‐Efficient Heterogeneous Organometallic Catalysis

“…This unorthodox ligand could be conveniently converted from oxidation of hydroquinone, and is relatively inert in many catalytic reaction types. Pillar[n]arenes (PA[n]s) are a new type of macrocyclic host molecules, [17] which have been used for variable applications, including drug delivery, [18][19][20][21] gas adsorption, [22,23] chemical separation, [24,25] fluorescence sensing, [26] ion channel [27,28] and catalysis. [29] PA[n] is of great importance for the construction of porous materials due to its intrinsic cavity.…”

Transformative Supramolecular Vesicles Based on Acid‐Degradable Acyclic Cucurbit[n]uril and a Prodrug for Promoted Tumoral‐Cell Uptake

“…The existing pH‐responsive supramolecular vesicles are typically based on “acid‐sensitive” hosts with carboxylic groups, such as water‐soluble pillar[ n ]arenes with carboxylic groups that can undergo protonation at acidic pH values . For these “acid‐sensitive” hosts, a subtle change in the pH from 7.4 (blood pH) to 6.5 (tumor acidity) is insufficient to trigger a significant reduction in binding strength to initiate vesicle morphology conversion . Therefore, to design supramolecular vesicles responsive to tumor acidity, it is necessary to use hosts that can undergo a dramatic change in binding affinity at tumor acidity levels.…”

“…[27] For these "acid-sensitive" hosts,asubtle change in the pH from 7.4 (blood pH) to 6.5 (tumor acidity) is insufficient to trigger as ignificant reduction in binding strengtht oi nitiate vesicle morphology conversion. [28] Therefore, to design supramolecular vesicles responsive to tumor acidity,i ti sn ecessary to use hosts that can undergo ad ramatic change in binding affinity at tumor acidity levels.…”

Water‐Soluble Pillar[n]arene Mediated Supramolecular Self‐Assembly: Multi‐Dimensional Morphology Controlled by Host Size

“…Water-soluble PA[n]s or WPnsa re unique for the reason that they are highly soluble in water,a nd could tightly bind methyl viologen and other bipyridinium guests ( Figure 1a). [20][21][22][23][24][25][26][27][28][29][30][31][32] Therefore, WPnsh ave similar physicala nd recognition property,a nd are perfect candidates to study the impactofhostsize toward self-assembly morphology of smallmolecule guests.…”