2009
DOI: 10.1163/156856208x386228
|View full text |Cite
|
Sign up to set email alerts
|

A Permanent Change in Protein Mechanical Responses Can be Produced by Thermally-Induced Microdomain Mixing

Abstract: Electrospinning was employed to fabricate three dimensional fiber networks from a recombinant amphiphilic elastin-mimetic triblock protein polymer and the effects of moderate thermal conditioning (60°C, 4h) on network mechanical responses investigated. Significantly, while cryo-high resolution scanning electron microscopy (cryo-HRSEM) revealed that macroscopic and microscopic morphology of the network structure was unchanged, solid-state 1H NMR spectroscopy demonstrated enhanced interphase mixing of hydrophobi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
7
0

Year Published

2010
2010
2017
2017

Publication Types

Select...
4
2

Relationship

3
3

Authors

Journals

citations
Cited by 9 publications
(8 citation statements)
references
References 40 publications
(71 reference statements)
1
7
0
Order By: Relevance
“…5. Thermal annealing enhanced burst pressure and suture retention while reducing compliance, consistent with prior observations that thermal annealing can increase the strength and Young’s modulus of this protein polymer [67]. The magnitude of the thermal annealing effect demonstrates that the mechanical behavior of the elastin component strongly influenced the composite mechanics and burst pressure.…”
Section: Resultssupporting
confidence: 85%
“…5. Thermal annealing enhanced burst pressure and suture retention while reducing compliance, consistent with prior observations that thermal annealing can increase the strength and Young’s modulus of this protein polymer [67]. The magnitude of the thermal annealing effect demonstrates that the mechanical behavior of the elastin component strongly influenced the composite mechanics and burst pressure.…”
Section: Resultssupporting
confidence: 85%
“…Elastin-based biomaterials have been processed as films [10,37-40], fibers [7,59], and hydrogels [34-36,56] for a variety of implant applications.…”
Section: Implant Applicationsmentioning
confidence: 99%
“…Tubular constructs have been produced by fiber deposition on a collecting mandrel with controlled rotational and translational speeds. Of interest, thermal annealing at 60 °C has been observed to changes the mechanical response of electrospun elastin protein polymer networks with a two fold increase in Young's modulus (0.366±0.05 MPa) and 30 % in tensile strength comparable to that within an arterial wall (Y ∼0.3 MPa) [59,71]. …”
Section: Implant Applicationsmentioning
confidence: 99%
See 1 more Smart Citation
“…The final structure was very stable, with the size of the micelle controlled by both the total ELP length and the hydrophilic-to-hydrophobic ratio. Sallach et al [69] investigated protein tri-block structures, with a central hydrophilic block and two hydrophobic end blocks. These were found to form monodisperse micelles in a narrow range of R H ~ 100 nm; however, when the temperature was raised above T t , a swift protein folding transition between α-helix and β-sheet structures caused an abrupt increase in micelle internal density, with a concomitant reduction in micelle size.…”
Section: Elastin-like Polypeptides and Other Recombinant Proteinsmentioning
confidence: 99%