A perfect stimuli-responsive magnetic nanocomposite for intracellular delivery of doxorubicin

Ghamkhari, Aliyeh; Ghorbani, Marjan; Aghbolaghi, Samira

doi:10.1080/21691401.2018.1518911

Cited by 25 publications

(8 citation statements)

References 39 publications

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“…Based on the in vitro drug release behavior dual responsiveness was observed leading to maintain the drug concentration at the target area. Further, the cytotoxicity results confirmed that the tailored formulation was more cytotoxic and biocompatible in contrast to native Dox [59] . Recently, an efficient ROS-sensitive sulfasalazine (SSZ) loaded magnetic nanosystem was developed for the treatment of rheumatoid arthritis (RA).…”

Section: Biomedical Application Of Hp-mnpsmentioning

confidence: 57%

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Kush

Kumar

Singh

et al. 2021

Asian Journal of Pharmaceutical Sciences

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This review covers extensively the synthesis & surface modification, characterization, and application of magnetic nanoparticles. For biomedical applications, consideration should be given to factors such as design strategies, the synthesis process, coating, and surface passivation. The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration. Special insights have been provided on biodistribution, pharmacokinetics, and toxicity in a living system, which is imperative for their wider application in biology. These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging, for example, MRI-CT, MRI-PET. Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body. Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction, heat conduction, imaging, and magnetism. Surely, this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction.

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Section: Biomedical Application Of Hp-mnpsmentioning

confidence: 57%

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Kush

Kumar

Singh

et al. 2021

Asian Journal of Pharmaceutical Sciences

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“…A novel copolymeric system of poly[(2-succinyloxyethylmethacrylate)-b-(N-isopropylacrylamide)-b dimethyl aminoethylmetha- crylate) was fabricated by RAFT polymerization. Using succinyloxyethylmethacrylate, a triblock copolymeric system was coated on the surface of Fe 3 O 4 nanoparticles to aid in the delivery of anticancer drugs [ 187 ]. A dual pH- and magnetic field-responsive magnetite coated with Eudragit ® S100 was fabricated and loaded with amoxicillin.…”

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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“…AA), such functional groups can also be generated by the chemical modification of preformed non‐functional polymers. For example, Ghamkhari et al 58 . prepared dual stimuli‐RMPHs starting from poly(2‐hydroxyethylmethacrylate)‐ block ‐poly( N ‐isopropylacrylamide)‐ block ‐poly( N , N ‐dimethylaminoethylmethacrylate) triblock copolymers (PHEMA ‐b‐ PNIPAM ‐b‐ PDMAEMA), which do not form strong complexes with MNPs.…”

Section: Stimuli‐responsive Magnetic Polymer Hybridsmentioning

confidence: 99%

Rational design of stimuli‐responsive magnetic polymer hybrid (nano)materials

Nguyen

Ménager

Rieger

et al. 2023

Polymer International

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Combining organic and inorganic materials is a fascinating strategy to produce hybrid materials that combine the advantages of both polymeric and inorganic materials. Among the various types of organic–inorganic hybrids, stimuli‐responsive magnetic polymer hybrids (RMPHs) are particularly promising materials for a wide variety of applications. While the magnetic properties are generally provided by the presence of magnetic nanoparticles, such as iron oxide nanoparticles, the polymeric compound brings the stimuli‐responsiveness, e.g. responsiveness to pH, temperature, redox reaction or irradiation. Furthermore, as the chemical structure and architecture of the polymeric materials are diverse and easily tunable, stimuli‐RMPHs have found applications in various domains, including catalysis, biotechnology, (bio)imaging and cancer therapy. Given the importance of the hybrids' shape and morphology for the targeted application, this review presents the possible synthetic strategies to rationally design stimuli‐RMPHs of various morphologies ranging from nanometric core–shell structures to nanogels, microgels and membranes. © 2023 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.

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A perfect stimuli-responsive magnetic nanocomposite for intracellular delivery of doxorubicin

Cited by 25 publications

References 39 publications

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Rational design of stimuli‐responsive magnetic polymer hybrid (nano)materials

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