A PEG-CMC-THB-PRTM hydrogel with antibacterial and hemostatic properties for promoting wound healing

Zhou, Quan; Zhou, Xujie; Mo, Zhendong; Zhang, Zheng; Wang, Zhenfang; Cai, Zhuangzhuang; Luo, Lei; Ding, Qiang; Li, Hang; Tang, Shunqing

doi:10.1016/j.ijbiomac.2022.10.130

Cited by 15 publications

(5 citation statements)

References 35 publications

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“…The results implied that the urethane/urea linkage enhanced the network's flexibility. 26 In the PCLUU/CS composite scaffolds, the network was formed via a hydrogen bond. The sample was broken in a single compressive test with max %strain of 88% and strength of 15.82 MPa.…”

Section: Compressive Testingmentioning

confidence: 99%

Effect of incorporation of star‐shaped polycaprolactone on structure‐properties relationship of chitosan‐based networks via urethane/urea linkage

Amonkol,

Choochottiros

2024

J of Applied Polymer Sci

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A chitosan‐based network was fabricated using hexamethylene diisocyanate as a crosslinking agent. The effect was investigated of incorporating star‐shaped polycaprolactone (stPCL) into chitosan‐based networks (CS/stPCL), where the stPCL content varied from 10 to 50 wt%. Quantitative analyses of the urethane/urea linkages and of the stPCL content in the networks were determined based on curve fitting and Soxhlet extraction, respectively. The optimum weight ratio was 80:20 for CS and stPCL (80CS20stPCL), with the highest urethane/urea linkages and stPCL content in the network (30.73%). The compressive testing and rheological analysis indicated that incorporating stPCL enhanced the compressive strength and rheological properties of the chitosan‐based network. In addition, the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide assay of the CS/stPCL network had a cell viability percentage greater than 70%. The CS/stPCL network promoted the formation of an apatite layer on the surface, indicating that the CS/stPCL network could be a promising candidate for tissue engineering.

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Section: Compressive Testingmentioning

confidence: 99%

Effect of incorporation of star‐shaped polycaprolactone on structure‐properties relationship of chitosan‐based networks via urethane/urea linkage

Amonkol,

Choochottiros

2024

J of Applied Polymer Sci

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“…The basic structure of PEG comprises a PEG diol with two terminal hydroxyl groups. These groups can be converted into various other functional groups, such as amine, carboxyl, vinyl sulfone, thiol, acetylene, acrylate, and aldehyde groups, enabling their conjugation with other materials [ 209 , 210 ].…”

Section: Polymersmentioning

confidence: 99%

“…Studies have shown that PEG can improve the mechanical strength, stability, and degradation rate of hydrogels [ 54 , 57 , 209 , 210 ]. However, it has also been reported that PEG hydrogels are brittle and weak [ 223 ].…”

Section: Polymersmentioning

confidence: 99%

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Ribeiro,

Simões,

Vitorino

et al. 2024

Gels

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Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol. This review offers a comprehensive overview and critical analysis of the key polymers that can constitute hydrogels, beginning with a brief contextualization of the polymers. It delves into their function, origin, and chemical structure, highlighting key sources of extraction and obtaining. Additionally, this review encompasses the main intrinsic properties of these polymers and their roles in the wound healing process, accompanied, whenever available, by explanations of the underlying mechanisms of action. It also addresses limitations and describes some studies on the effectiveness of isolated polymers in promoting skin regeneration and wound healing. Subsequently, we briefly discuss some application strategies of hydrogels derived from their intrinsic potential to promote the wound healing process. This can be achieved due to their role in the stimulation of angiogenesis, for example, or through the incorporation of substances like growth factors or drugs, such as antimicrobials, imparting new properties to the hydrogels. In addition to substance incorporation, the potential of hydrogels is also related to their ability to serve as a three-dimensional matrix for cell culture, whether it involves loading cells into the hydrogel or recruiting cells to the wound site, where they proliferate on the scaffold to form new tissue. The latter strategy presupposes the incorporation of biosensors into the hydrogel for real-time monitoring of wound conditions, such as temperature and pH. Future prospects are then ultimately addressed. As far as we are aware, this manuscript represents the first comprehensive approach that brings together and critically analyzes fundamental aspects of both natural and synthetic polymers constituting hydrogels in the context of cutaneous wound healing. It will serve as a foundational point for future studies, aiming to contribute to the development of an effective and environmentally friendly dressing for wounds.

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“…Because the structure of PEG is easy to modify, it can be altered to change its physical properties. 85 PEG is commonly used as a sealant to prevent leakage of liquid and air after surgery. 86,87 At present, the development of synthetic chemical adhesives mostly involves the modification of existing medical polymeric materials and combining them with different chemical substances to make them have more abundant functionalities.…”

Section: Organic Synthetic Adhesive Materialsmentioning

confidence: 99%

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

Liu

2023

J. Mater. Chem. B

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A PEG-CMC-THB-PRTM hydrogel with antibacterial and hemostatic properties for promoting wound healing

Cited by 15 publications

References 35 publications

Effect of incorporation of star‐shaped polycaprolactone on structure‐properties relationship of chitosan‐based networks via urethane/urea linkage

Effect of incorporation of star‐shaped polycaprolactone on structure‐properties relationship of chitosan‐based networks via urethane/urea linkage

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Recent advances in adhesive materials used in the biomedical field: adhesive properties, mechanism, and applications

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