2022
DOI: 10.1007/s10014-021-00423-0
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A patient with two gliomas with independent oligodendroglioma and glioblastoma biology proved by DNA-methylation profiling: a case report and review of the literature

Abstract: Here, we report on a patient presenting with two histopathologically distinct gliomas. At the age of 42, the patient underwent initial resection of a right temporal oligodendroglioma IDH mutated 1p/19q co-deleted WHO Grade II followed by adjuvant radiochemotherapy with temozolomide. 15 months after initial diagnosis, the patient showed right hemispheric tumor progression and an additional new left frontal contrast enhancement in the subsequent imaging. A re-resection of the right-sided tumor and resection of t… Show more

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Cited by 5 publications
(8 citation statements)
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“…The lambda tumor-induced group, plain GQD treated, GQD-BSA conjugate treated, and GQD-Trastuzumab conjugate treated groups showed disturbed and altered cell bodies with extracellular space, scar formation, and hippocampal gliosis. While the GQD-Caspase 8 conjugate-treated group showed recuperate changes in damaged cell structures, reduced inflammation, and neurodegeneration [71,72].…”
Section: Histopathological Evaluation Of Gqd-treated Brain Tumor-indu...mentioning
confidence: 92%
“…The lambda tumor-induced group, plain GQD treated, GQD-BSA conjugate treated, and GQD-Trastuzumab conjugate treated groups showed disturbed and altered cell bodies with extracellular space, scar formation, and hippocampal gliosis. While the GQD-Caspase 8 conjugate-treated group showed recuperate changes in damaged cell structures, reduced inflammation, and neurodegeneration [71,72].…”
Section: Histopathological Evaluation Of Gqd-treated Brain Tumor-indu...mentioning
confidence: 92%
“…Molecular genetic analyses for IDH1 , IDH2 mutations, as well as DNA methylation were performed as previously described [ 26 , 27 , 28 ]. In brief, representative tumor regions were microscopically identified and dissected.…”
Section: Methodsmentioning
confidence: 99%
“…Mutational analysis of IDH1 and IDH2 genes was performed with either the AmpliSeq for Illumina Cancer Hotspot Panel v2 (Illumina, San Diego, CA, USA) or the AmpliSeq for Illumina Focus Panel (Illumina), respectively. Next generation sequencing was performed on an Illumina MiniSeq device following the manufacturer’s protocol [ 26 , 27 , 28 ].…”
Section: Methodsmentioning
confidence: 99%
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