A patient with sarcoidosis diagnosed by a biopsy of scleral nodules

Abstract

A scleral biopsy is useful for the diagnosis of sarcoidosis when the patient has nodular scleritis with no systemic signs.

Sarcoid Uveitis

“…When no improvement was seen in the scleral and skin lesions following 4 months of treatment, triamcinolone acetonide injections were given for the skin lesions and consideration was given to adding systemic methotrexate. While scleral involvement has been reported previously in patients with sarcoidosis, [30][31][32] there was, in each case, evidence of inflammation of the sclera, or scleritis, as opposed to the painless nodule noted in this patient.…”

Scleral granuloma associated with presumed diffuse immune lymphocytosis syndrome

“…Scleral granulomas have been found in association with different systemic conditions. [6][7][8][9][10] To our knowledge this is the first report of scleral granuloma occurring in the presence of presumed DILS. During HIV infection the immune system becomes dysfunctional because of the coexistence of immunodeficiency and immune hyperactivity, and a disregulated production or activity of cytokines, thereby explaining the development of the DILS.…”

Sarcoidosis

“…Cassoux et al [56] diagnosed sarcoidosis by endoretinal biopsy in a patient with posterior uveitis unresponsive to corticosteroid therapy and negative systemic evaluation. Saito et al [57] reported a patient with nodular scleritis and negative systemic evaluation who was diagnosed with sarcoidosis by a biopsy of scleral nodules.…”