Sarcoid Uveitis

Cunningham, Emmett T.; Lowder, Careen Y.; Miserocchi, Elisabetta; Thorne, Jennifer E.; Zierhut, Manfred

doi:10.3109/09273948.2014.941235

Cited by 7 publications

(2 citation statements)

References 33 publications

(49 reference statements)

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“…Sarcoidosis or Morbus Boeck is a multisystem disorder of unknown cause[ 1 , 2 , 3 ]. The organs involved are histologically characterized by non-caseating granulomas.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-2 Receptor and Angiotensin-Converting Enzyme as Markers for Ocular Sarcoidosis

et al. 2016

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PurposeTo study the impact of soluble IL2 receptor (sIL2R), chest x-ray (CxR), and angiotensin-converting enzyme (ACE) as markers for sarcoidosis in uveitis patients.DesignRetrospective study.MethodsSerum concentrations of sIL2R and ACE were measured in patients with active uveitis. Those with elevated sIL2R and /or ACE values were examined for suspected systemic sarcoidosis.Main Outcome MeasureOur main outcome parameters were the specificity and sensitivity of sIL2R, CxR and ACE in screening for ocular sarcoidosis.ResultsWe measured 261 patients with uveitis for sarcoidosis using sIL2R and ACE between January 2008 and November 2011; sarcoidosis was been diagnosed using other tests (e.g. computer tomography, brochoalveolar lavage, biopsy) in 41 of 53 patients with elevated sIL2R values (>639 U/ml) and in one patient with normal sIL2R (582 U/ml). Their mean sIL2R value was 1310 U/ml, extending from 582 to 8659 U/ml. Only 9 patients, however, presented elevated ACE (>82 U/l). Their mean ACE value was 116.4 U/l, ranging from 84.1 to 175.5 U/l. IL2R specificity was 94% with 98% sensitivity. In contrast, ACE had a specificity of 99.5%, but a sensitivity of only 22%; the chest x-ray had a specificity of 100% with 50% sensitivity in detecting sarcoidosis. We observed the entire spectrum of uveitis: sixteen patients suffered from anterior, 8 from intermediate, 16 from posterior, and 2 from panuveitis.ConclusionsAn elevated level of soluble IL2R suggests sarcoidosis with uveitis more convincingly than ACE, making sIL2R a more effective marker parameter for sarcoidosis than ACE or chest x-ray in uveitis patients.

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“…Sarcoidosis or Morbus Boeck is a multisystem disorder of unknown cause[ 1 , 2 , 3 ]. The organs involved are histologically characterized by non-caseating granulomas.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-2 Receptor and Angiotensin-Converting Enzyme as Markers for Ocular Sarcoidosis

et al. 2016

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“…and can have vermiform margins 65 . Inactive posterior segment lesions included perivascular gliosis, focal chorioretinal scarring, and chorioretinal folds 66 …”

Section: Ocular Investigationsmentioning

confidence: 99%

Insights into the diagnosis and management of sarcoid uveitis: A review

Samalia,

Lim,

Niederer

2024

Clinical Exper Ophthalmology

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Sarcoidosis is a leading cause of non‐infectious uveitis that commonly affects middle‐aged individuals and has a female preponderance. The disease demonstrates age, sex and ethnic differences in clinical manifestations. A diagnosis of sarcoidosis is made based on a compatible clinical presentation, supporting investigations and histologic evidence of non‐caseating granulomas, although biopsy is not always possible. Multimodal imaging with widefield fundus photography, optical coherence tomography and angiography can help in the diagnosis of sarcoid uveitis and in the monitoring of treatment response. Corticosteroid remains the mainstay of treatment; chronic inflammation requires steroid‐sparing immunosuppression. Features on multimodal imaging such as vascular leakage may provide prognostic indicators of outcome. Female gender, prolonged and severe uveitis, and posterior involving uveitis are associated with poorer visual outcomes.

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Differential Diagnosis of Noninfectious Retinitis

Androudi¹,

Dastiridou²

2019

The Uveitis Atlas

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Sarcoid Uveitis

Cited by 7 publications

References 33 publications

Interleukin-2 Receptor and Angiotensin-Converting Enzyme as Markers for Ocular Sarcoidosis

Interleukin-2 Receptor and Angiotensin-Converting Enzyme as Markers for Ocular Sarcoidosis

Insights into the diagnosis and management of sarcoid uveitis: A review

Differential Diagnosis of Noninfectious Retinitis

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