A Patient-Level Data Meta-analysis of the Abscopal Effect

WITHDRAWN: ASTRO's Advances in Radiation Oncology in 2022

“…1 Flavin et al reports on the national impact on radiotherapy delivery after a cyberattack on the public health services of the Republic of Ireland. 2 Additional review papers included in this issue are a review of management of implantable devices by Chan et al 3 and on the Abscopal effect by Hatten, et al 4 We welcome inquiries regarding proposed review papers and encourage potential authors to contact the Editor in Chief directly at miller.robert@mayo.edu to discuss their proposal.…”

An oldest‐old non‐small cell lung cancer patient with abscopal effect in a single lesion

“…Additionally, as to the reason of such insufficient abscopal effect, decreased immunity due to aging, high expression of PD‐L1 of the tumor, and low dose per fraction irradiation might be related. To the best of our knowledge, although there have been no reports evaluating the relationship between aging and the abscopal effect in detail, one review described that the mean age mentioned in the case reports was 57.5 years with a standard deviation of 15.1 years, 6 and that reports of abscopal effects in oldest‐old patients were extremely rare 7 . As for the relationship between immunity and aging, a reduction in T cell diversity is seen in older individuals and linked with increased susceptibility to infection, autoimmune disease, and cancer.…”

“…To the best of our knowledge, although there have been no reports evaluating the relationship between aging and the abscopal effect in detail, one review described that the mean age mentioned in the case reports was 57.5 years with a standard deviation of 15.1 years, 6 and that reports of abscopal effects in oldestold patients were extremely rare. 7 As for the relationship between immunity and aging, a reduction in T cell diversity is seen in older individuals and linked with increased susceptibility to infection, autoimmune disease, and cancer. Furthermore, age-related regression of the thymus is one of the most dramatic and ubiquitous changes seen in the aging immune system.…”

Combining concurrent radiotherapy and immunotherapy for synergistic effects in recurrent endometrial cancer – A case report

“…Currently, immunotherapy is approved for advanced endometrial cancer patients who have disease progression following prior systemic therapy. A systematic review of published literature failed to reveal any studies that concomitantly combined immunotherapy and radiotherapy ( Mehnert et al, 2016 , Hasumi et al, 2011 , Genç et al, 2015 , Altorki et al, 2021 , Hatten et al, 2022 ). In the vignettes we presented, it is possible that immunotherapy alone may have eradicated the sites of local and distant disease.…”