A patient from Mali with Actinomadura bangladeshensis-induced foot mycetoma: A diagnostic challenge

Bérot, V.; Ousser, Ahmed-Fateh; Sougakoff, Wladimir; Lecso, Gabriel; Monsel, Gentiane; Caumes, Éric

doi:10.1016/j.tmaid.2019.07.008

Cited by 9 publications

(2 citation statements)

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“…Other eumycetoma species were identified in Africa and included Sphaerulina rhododetricola, Pleurostomophora ochracea, Curvularia pseudolunata, Chaetomium atrobrunneum, and Microascus gracilis [50][51][52][53]. For actinomycetoma, many new organisms were identified as causative organisms, and these are Streptomyces sudanensis, Actinomadura Mexicana reported from Sudan, Actinomadura bengladeshensis from a patient from Mali, and Nocardia boironii from France [54][55][56][57].…”

Section: New Causative Organisms Identificationmentioning

confidence: 99%

Mycetoma and the environment

Fahal,

Bakhiet

2023

PLoS Negl Trop Dis

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Mycetoma is a chronic, incapacitating, destructive inflammatory disease with many serious damaging impacts. Currently, there is no control or prevention program as many of its epidemiological characteristics, such as the causative organisms’ ecological niche, natural habitat, primary reservoir, transmission mode, geographical distribution, incidence, and prevalence, remain unclear. This may be due to a lack of research interest, as mycetoma is still a neglected disease and the scarcity of accurate molecular diagnostic techniques in disease-endemic regions for accurate causative microorganisms identification and mapping. With this background, this study set out to address this knowledge gap by considering the mycetoma environmental occurrence predictors. The medical literature obtained data showed a close association between mycetoma occurrence and its environment. The causative microorganisms are available in the environment in active or dormant forms. Animal dung may be a natural niche and reservoir for these organisms, and thorns may facilitate the subcutaneous inoculation. Some environmental factors, such as the soil type and consistency, temperature, water sources, aridity index, and thorny trees, may be risk factors. The population in endemic areas socioeconomic, hygiene, and health education status are contributory factors for mycetoma. The individual’s genetic and immunological backgrounds may determine the disease’s susceptibility and resistance. Environmental conditions and personal hygiene improvement are mandatory to reduce disease occurrence. Mycetoma spatial mapping can detect disease cluster areas and then develop public health strategies for early case detection and management to reduce the disease burden. More research interests and facilities are needed to understand disease pathogenesis and appropriate patient management better.

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Section: New Causative Organisms Identificationmentioning

confidence: 99%

Mycetoma and the environment

Fahal,

Bakhiet

2023

PLoS Negl Trop Dis

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“…Most notably, the putative CMN-resistant genes exist in several Mycobacterium and Mycolicibacterium species, which belong to non-tuberculosis Mycobacterium (NTM), known as a group of bacteria that causes rare lung infections and immune systems depression 39 . Furthermore, the putative CMN-resistant genes have also been found in many human pathogens, including Nocardia vulneris (disseminated nocardiosis) 40 , Mycolicibacterium fortuitum (pulmonary infections) 41 , Mycobacterium septicum (associated with catheter-related bacteraemia) 42 , and Actinomadura bangladeshensis (A. bangladeshensisinduced foot mycetoma) 43 . These indicate that the putative CMN-resistant genes are distributed in not only the environmental bacteria but also human pathogens.…”

Section: The Putative Cmn-resistant Genes Are Widespread In Nature An...mentioning

confidence: 99%

Discovery and Characterization of Genes Conferring Natural Resistance to the Antituberculosis Antibiotic Capreomycin

Chang,

Ing,

Keisha

et al. 2023

Preprint

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Metagenomic-based studies have predicted an extraordinary number of potential antibiotic-resistant genes (ARGs). These ARGs are hidden in various environmental bacteria and may become a latent crisis for antibiotic therapy via horizontal gene transfer. In this study, we focus on a resistance gene cph, which encodes a phosphotransferase (Cph) that confers resistance to the antituberculosis drug capreomycin (CMN). Sequence Similarity Network analysis classified 353 Cph homologues into five major clusters. We examined the function and targeted antibiotics of three putative resistance proteins in cluster I via bioinformatics, biochemical, and protein structural analysis. We found that the proteins in cluster I are from various species and indeed confer resistance to CMN. This study contributes towards understanding the sequence-structure-function relationships of the phosphorylation resistance genes that confer resistance to CMN.

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Nocardia, Rhodococcus, Streptomyces and Other Aerobic Actinomycetes

Valdezate

2022

Encyclopedia of Infection and Immunity

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A patient from Mali with Actinomadura bangladeshensis-induced foot mycetoma: A diagnostic challenge

Cited by 9 publications

References 0 publications

Mycetoma and the environment

Mycetoma and the environment

Discovery and Characterization of Genes Conferring Natural Resistance to the Antituberculosis Antibiotic Capreomycin

Nocardia, Rhodococcus, Streptomyces and Other Aerobic Actinomycetes

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